HDAC6-IN-34
HDAC6-IN-34 (compound 21) is an oral active and selective HDAC6 inhibitor with the IC50 of 18 nM. HDAC6-IN-34 increases the acetylation level of tubulin without affecting histone acetylation in cutaneous T-cell lymphoma cells and inhibits TNF-α secretion in LPS (HY-D1056)-stimulated macrophage cells. HDAC6-IN-34 shows excellent anti-arthritic efficacy in rat.
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- CAS. Nr.: 1432508-73-0
- Formel: C18H18F3N3O3
- Molecular Weight:381.35
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
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Help & FAQs
Biologische Aktivität
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HDAC6 18 nM (IC50) |
HDAC1 3.91 μM (IC50) |
Chemical Information
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CAS. Nr. 1432508-73-0
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Molecular Weight 381.35
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Formel C18H18F3N3O3
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SMILES
CC1(CC(C2=C(N(N=C2C(F)(F)F)CC3=CC=C(C=C3)C(NO)=O)C1)=O)C
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
HDAC6-IN-34 Related Classifications
HY-163368 Related Classifications
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