1432508-73-0
1432508-73-0
Chemical Structure
HDAC6-IN-34
- CAS No.: 1432508-73-0
- Formula:C18H18F3N3O3
- Molecular Weight:381.35
InChIKey: AUEDMSVXWKXTGU-UHFFFAOYSA-N
SMILES: CC1(CC(C2=C(N(N=C2C(F)(F)F)CC3=CC=C(C=C3)C(NO)=O)C1)=O)C
Biological Activity: HDAC6-IN-34 (compound 21) is an oral active and selective HDAC6 inhibitor with the IC50 of 18 nM. HDAC6-IN-34 increases the acetylation level of tubulin without affecting histone acetylation in cutaneous T-cell lymphoma cells and inhibits TNF-α secretion in LPS (HY-D1056)-stimulated macrophage cells. HDAC6-IN-34 shows excellent anti-arthritic efficacy in rat[1].
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HDAC6-IN-34 | HDAC6-IN-34 (compound 21) is an oral active and selective HDAC6 inhibitor with the IC50 of 18 nM. HDAC6-IN-34 increases the acetylation level of tubulin without affecting histone acetylation in cutaneous T-cell lymphoma cells and inhibits TNF-α secretion in LPS (HY-D1056)-stimulated macrophage cells. HDAC6-IN-34 shows excellent anti-arthritic efficacy in rat. | |||||||||||||||||||||
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References
Keywords
