Art. -Nr.: HY-N7394A

(-)-Zuonin A

(Synonyms: D-Epigalbacin)

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

(-)-Zuonin A (D-Epigalbacin), a naturally occurring lignin, is a potent, selective JNKs inhibitor, with IC₅₀s of 1.7 μM, 2.9 μM and 1.74 μM for JNK1, JNK2 and JNK3, respectively.

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Reinheit: 99.99%
CAS. Nr.: 84709-25-1
Formel: C₂₀H₂₀O₅
Molecular Weight:340.37

Speicherung:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

(-)-Zuonin A Chemical Structure

CAS. Nr.: 84709-25-1

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Publications (1)
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

(-)-Zuonin A (D-Epigalbacin), a naturally occurring lignin, is a potent, selective JNKs inhibitor, with IC₅₀s of 1.7 μM, 2.9 μM and 1.74 μM for JNK1, JNK2 and JNK3, respectively^[1].

IC₅₀ & Target^[1]

JNK1

1.7 μM (IC₅₀)

JNK2

2.9 μM (IC₅₀)

JNK3

1.74 μM (IC₅₀)

Alle JNK Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
Platelet	IC₅₀	34.9 μM Compound: 17	Antiplatelet activity against New Zealand white rabbit platelets assessed as inhibition of ADP-induced platelet aggregation preincubated for 2 mins before challenge measured after 2 mins by spectrophotometry Antiplatelet activity against New Zealand white rabbit platelets assessed as inhibition of ADP-induced platelet aggregation preincubated for 2 mins before challenge measured after 2 mins by spectrophotometry	[PMID: 24387347]

In Vitro

(?)-zuonin A binds the D-recruitment site (DRS) of JNK, a recruitment site utilized by substrates and other substrates to dock onto and recognize MAPKs^[1].
(?)-zuonin A inhibits the activation and phosphorylation of JNK by MKK4 and MKK7^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 84709-25-1
Appearance Solid
Molecular Weight 340.37
Formel C₂₀H₂₀O₅
Color White to off-white
SMILES

C[C@H]1[C@@H](C)[C@@H](C2=CC=C(OCO3)C3=C2)O[C@@H]1C4=CC=C(OCO5)C5=C4
Synonyms

D-Epigalbacin
Structure Classification
- Phenylpropanoids
- Lignans
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (1)

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Journal Impact Factor

Cell Mol Neurobiol

Neuroprotective Effect of miR-483-5p Against Cardiac Arrest-Induced Mitochondrial Dysfunction Mediated Through the TNFSF8/AMPK/JNK Signaling Pathway. [Abstract]

2023 Jul;43(5):2179-2202. PMID: 36266523

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 50 mg/mL (146.90 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.9380 mL

14.6899 mL

29.3798 mL

5 mM

0.5876 mL

2.9380 mL

5.8760 mL

10 mM

0.2938 mL

1.4690 mL

2.9380 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Tamer S. Kaoud, et al. Manipulating JNK Signaling with (−)-zuonin A. ACS Chem Biol. 2012 Nov 16; 7(11): 1873–1883. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.9380 mL	14.6899 mL	29.3798 mL	73.4495 mL
	5 mM	0.5876 mL	2.9380 mL	5.8760 mL	14.6899 mL
	10 mM	0.2938 mL	1.4690 mL	2.9380 mL	7.3449 mL
	15 mM	0.1959 mL	0.9793 mL	1.9587 mL	4.8966 mL
	20 mM	0.1469 mL	0.7345 mL	1.4690 mL	3.6725 mL
	25 mM	0.1175 mL	0.5876 mL	1.1752 mL	2.9380 mL
	30 mM	0.0979 mL	0.4897 mL	0.9793 mL	2.4483 mL
	40 mM	0.0734 mL	0.3672 mL	0.7345 mL	1.8362 mL
	50 mM	0.0588 mL	0.2938 mL	0.5876 mL	1.4690 mL
	60 mM	0.0490 mL	0.2448 mL	0.4897 mL	1.2242 mL
	80 mM	0.0367 mL	0.1836 mL	0.3672 mL	0.9181 mL
	100 mM	0.0294 mL	0.1469 mL	0.2938 mL	0.7345 mL

Keywords

(-)-Zuonin A

1 Cited Publications

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(-)-Zuonin A

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Publications Citing Use of MedChemExpress (MCE) (-)-Zuonin A

Alle JNK Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (1)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

(-)-Zuonin A Related Classifications

HY-N7394A Related Classifications