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Art. -Nr.: HY-184225

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PROTAC TEAD degrader-3

PROTAC TEAD degrader-3 is a TEAD PROTAC degrader with an IC₅₀ of < 5 nM against TEAD1, TEAD2, TEAD3 and TEAD4. PROTAC TEAD degrader-3 promotes ubiquitination and degradation of TEAD1/2/3/4. PROTAC TEAD degrader-3 can be used in cancer research.
(Pink: TEAD1 and TEAD2 and TEAD3 and TEAD4 ligand (HY-186023); Blue: E3 ligase ligand; Black: linker).

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CAS. Nr.: 3120075-62-6
Formel: C₅₄H₅₉ClF₄N₈O₆
Molecular Weight:1027.54

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

PROTAC TEAD degrader-3 Chemical Structure

CAS. Nr.: 3120075-62-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

PROTAC TEAD degrader-3 is a TEAD PROTAC degrader with an IC₅₀ of < 5 nM against TEAD1, TEAD2, TEAD3 and TEAD4. PROTAC TEAD degrader-3 promotes ubiquitination and degradation of TEAD1/2/3/4. PROTAC TEAD degrader-3 can be used in cancer research^[1]. (Pink: TEAD1 and TEAD2 and TEAD3 and TEAD4 ligand (HY-186023); Blue: E3 ligase ligand; Black: linker).

IC₅₀ & Target^[1]

TEAD1

<5 nM (IC₅₀)

TEAD2

<5 nM (IC₅₀)

TEAD3

<5 nM (IC₅₀)

TEAD4

<5 nM (IC₅₀)

Alle PROTACs Isoform-spezifische Produkte anzeigen :

Alle YAP Isoform-spezifische Produkte anzeigen :

In Vitro

PROTAC TEAD degrader-3 (Compound 106A) potently degrades HiBit-tagged TEAD1, TEAD2, TEAD3, and TEAD4 in HEK293 cells, with an IC₅₀ < 5 nM for each isoform^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 3120075-62-6
Molecular Weight 1027.54
Formel C₅₄H₅₉ClF₄N₈O₆
SMILES

COC1=C(F)[C@@]([C@@]2=C(Cl)C(F)=CC3=C2[C@H](C)[C@@](CN[C@H]4CC[C@H](C(N5CCC(CN6CCC(C7=C(F)C(N(C)N=C8N9CCC(NC9=O)=O)=C8C=C7F)CC6)CC5)=O)CC4)(C%10=CC=CC=C%10)O3)=C(C(N)=O)C=C1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Renner AC, et al. Targeted Protein Degradation and Metabolic Inhibition as Complementary Therapeutic Strategies: TEAD PROTACs and NAT8L Inhibitors in Oncology. ACS Med Chem Lett. 2026 May 25;17(6):1249-1252. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise

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PROTAC TEAD degrader-3

Alle PROTACs Isoform-spezifische Produkte anzeigen

Alle YAP Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

PROTAC TEAD degrader-3 Related Classifications

HY-184225 Related Classifications