YWHAQ - tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta Gene

Also Known as 1C5; HS1; 14-3-3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10971

About YWHAQ

Cytogenetic location: 2p25.1 Genomic coordinates (GRCh38): 2:9,583,967-9,630,997 (from NCBI)

This gene has 5 transcripts (splice variants), 275 orthologues and 6 paralogues. Ubiquitous expression in brain (RPKM 160.3), endometrium (RPKM 117.5) and 25 other tissues.

Summary

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both Plants and mammals, and this protein is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with amyotrophic lateral sclerosis. It contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic, however, there is no correlation between the repeat number and the disease. [provided by RefSeq, Jul 2008]

YWHAQ Products (1)

mRNA	Protein	Name
NM_006826.4	NP_006817.1	2014/3/3 protein theta

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	17085597	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7760835	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15163635	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	15163635	GOA
located in nucleus	IDA IDA: Inferred from direct assay	31906564	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	22797923	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

YWHAQ Protein Structure

14-3-3

0
100
200
245 a.a.

Protein Preferred Names	Protein Names
14-3-3 protein theta	14-3-3 protein T-cell

YWHAQ Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	YWHAQ	P27348	MPRIP	Homo sapiens	Q6WCQ1	Anti Tag CoIP	35271311
Intra	YWHAQ	P27348	MPRIP	Homo sapiens	Q6WCQ1	Anti Bait CoIP	17353931
Intra	YWHAQ	P27348	MPRIP	Homo sapiens	Q6WCQ1	Anti Tag CoIP	33961781
Intra	YWHAQ	P27348	MPRIP	Homo sapiens	Q6WCQ1	Anti Tag CoIP	28514442
Intra	YWHAQ	P27348	MPRIP	Homo sapiens	Q6WCQ1	BioID	36931259
Intra	YWHAQ	P27348	CDK14	Homo sapiens	O94921	Y2H	16775625
Intra	YWHAQ	P27348	CDK14	Homo sapiens	O94921	Anti Tag CoIP	16775625
Intra	YWHAQ	P27348	CDK14	Homo sapiens	O94921	Anti Tag CoIP	36931259
Intra	YWHAQ	P27348	PI4KB	Homo sapiens	Q9UBF8	Anti Tag CoIP	36931259
Intra	YWHAQ	P27348	PI4KB	Homo sapiens	Q9UBF8	Anti Tag CoIP	33961781
Intra	YWHAQ	P27348	PI4KB	Homo sapiens	Q9UBF8	Anti Tag CoIP	28514442
Intra	YWHAQ	P27348	PI4KB	Homo sapiens	Q9UBF8	Anti Tag CoIP	35271311
Intra	YWHAQ	P27348	PI4KB	Homo sapiens	Q9UBF8	Anti Bait CoIP	17353931
Intra	YWHAQ	P27348	CCDC125	Homo sapiens	Q86Z20	Validated Y2H	32296183
Intra	YWHAQ	P27348	ADAM22	Homo sapiens	Q9P0K1-3	Y2H	16868027
Intra	YWHAQ	P27348	KIF1C	Homo sapiens	O43896	Anti Tag CoIP	36931259
Intra	YWHAQ	P27348	KIF1C	Homo sapiens	O43896	Anti Tag CoIP	33961781
Intra	YWHAQ	P27348	KIF1C	Homo sapiens	O43896	Anti Tag CoIP	28514442
Intra	YWHAQ	P27348	KANK1	Homo sapiens	Q14678	Pull Down	19559006
Intra	YWHAQ	P27348	KANK1	Homo sapiens	Q14678	Anti Bait CoIP	18458160
Intra	YWHAQ	P27348	EGFR	Homo sapiens	P00533	Ub Reconstruction	24658140
Intra	YWHAQ	P27348	MAP3K3	Homo sapiens	Q99759	Anti Tag CoIP	33961781
Intra	YWHAQ	P27348	MAP3K3	Homo sapiens	Q99759	Anti Tag CoIP	28514442
Intra	YWHAQ	P27348	MAP3K3	Homo sapiens	Q99759	Anti Tag CoIP	36931259
Intra	YWHAQ	P27348	HDAC4	Homo sapiens	P56524	Anti Tag CoIP	33961781
Intra	YWHAQ	P27348	HDAC4	Homo sapiens	P56524	Anti Tag CoIP	28514442
Intra	YWHAQ	P27348	HDAC4	Homo sapiens	P56524	BioID	36931259
Intra	YWHAQ	P27348	FGA	Homo sapiens	P02671	Anti Tag CoIP	28514442
Intra	YWHAQ	P27348	YWHAE	Homo sapiens	P62258	Y2H Pooling	20936779
Intra	YWHAQ	P27348	YWHAE	Homo sapiens	P62258	Anti Tag CoIP	33961781
Intra	YWHAQ	P27348	YWHAE	Homo sapiens	P62258	Anti Tag CoIP	36931259
Intra	YWHAQ	P27348	YWHAE	Homo sapiens	P62258	Confocal	21988832
Intra	YWHAQ	P27348	YWHAE	Homo sapiens	P62258	Anti Tag CoIP	28514442
Intra	YWHAQ	P27348	YWHAE	Homo sapiens	P62258	Y2H	21988832
Intra	YWHAQ	P27348	YWHAE	Homo sapiens	P62258	Anti Tag CoIP	35271311
Intra	YWHAQ	P27348	YWHAB	Homo sapiens	P31946	Anti Tag CoIP	28514442
Intra	YWHAQ	P27348	YWHAB	Homo sapiens	P31946	Anti Tag CoIP	35271311
Intra	YWHAQ	P27348	YWHAB	Homo sapiens	P31946	BioID	36931259
Intra	YWHAQ	P27348	YWHAG	Homo sapiens	P61981	Anti Tag CoIP	35271311
Intra	YWHAQ	P27348	YWHAG	Homo sapiens	P61981	SLCA	17085597
Intra	YWHAQ	P27348	YWHAG	Homo sapiens	P61981	Anti Tag CoIP	28514442
Intra	YWHAQ	P27348	YWHAG	Homo sapiens	P61981	Anti Tag CoIP	36931259
Intra	YWHAQ	P27348	RAF1	Homo sapiens	P04049	Anti Tag CoIP	36931259
Intra	YWHAQ	P27348	RAF1	Homo sapiens	P04049	Anti Tag CoIP	33961781
Intra	YWHAQ	P27348	RAF1	Homo sapiens	P04049	Anti Tag CoIP	28514442
Intra	YWHAQ	P27348	RAF1	Homo sapiens	P04049	Anti Tag CoIP	35271311
Intra	YWHAQ	P27348	RAF1	Homo sapiens	P04049	Anti Bait CoIP	17353931
Intra	YWHAQ	P27348	CBL	Homo sapiens	P22681	CoIP	11697890
Intra	YWHAQ	P27348	CBL	Homo sapiens	P22681	Anti Tag CoIP	36931259
Intra	YWHAQ	P27348	CBL	Homo sapiens	P22681	CoIP	8663231
Intra	YWHAQ	P27348	CBL	Homo sapiens	P22681	Biochemical	11697890
Intra	YWHAQ	P27348	TRIM42	Homo sapiens	Q8IWZ5	Validated Y2H	25416956
Intra	YWHAQ	P27348	LRRK2	Homo sapiens	Q5S007	FPS	24351927
Intra	YWHAQ	P27348	KANK1	Homo sapiens	Q14678-2	Pull Down	18458160
Intra	YWHAQ	P27348	BAD	Homo sapiens	Q92934	Y2H	21988832
Intra	YWHAQ	P27348	BAD	Homo sapiens	Q92934	Anti Tag CoIP	28514442
Intra	YWHAQ	P27348	BAD	Homo sapiens	Q92934	Anti Tag CoIP	36931259
Intra	YWHAQ	P27348	BAD	Homo sapiens	Q92934	Anti Tag CoIP	33961781
Intra	YWHAQ	P27348	ITPRID2	Homo sapiens	P28290	Anti Tag CoIP	33961781
Intra	YWHAQ	P27348	ITPRID2	Homo sapiens	P28290	Anti Tag CoIP	28514442
Intra	YWHAQ	P27348	ITPRID2	Homo sapiens	P28290	BioID	36931259
Intra	YWHAQ	P27348	CDC25A	Homo sapiens	P30304	CoIP	19289404
Intra	YWHAQ	P27348	FSHR	Homo sapiens	P23945	Y2H	15196694
Intra	YWHAQ	P27348	FSHR	Homo sapiens	P23945	Lex-A Dimerization	20600589
Intra	YWHAQ	P27348	FSHR	Homo sapiens	P23945	Anti Bait CoIP	15196694
Intra	YWHAQ	P27348	ATXN1	Homo sapiens	P54253	Y2H Pooling	32814053
Intra	YWHAQ	P27348	ATXN1	Homo sapiens	P54253	BioID	36931259
Intra	YWHAQ	P27348	ATXN1	Homo sapiens	P54253	Validated Y2H	32814053
Intra	YWHAQ	P27348	ATXN1	Homo sapiens	P54253	Y2H Array	32814053
Cross	YWHAQ	P27348	tir	Escherichia coli O127:H6	B7UM99	IF	16367866

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant YWHAQ Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75548	14-3-3 theta Protein, Human (GST)	P27348 (M1-N245)	≥ 85%, as determined by reducing SDS-PAGE.

YWHAQ Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82210	14-3-3 theta Antibody (YA1955)	WB	Human, Mouse, Rat
HY-P82210A	14-3-3 theta Antibody (YA1955)(PBS only)	WB	Human, Mouse, Rat
HY-P84223	14-3-3 theta Antibody (YA3920)	WB, ELISA	Human, Mouse, Rat, Monkey
HY-P84223A	14-3-3 theta Antibody (YA3920)(PBS only)	WB, ELISA	Human, Mouse, Rat, Monkey

Related Diseases

Diseases	Alias
Lateral Sclerosis	Primary Lateral Sclerosis Adult-Onset Primary Lateral Sclerosis Adult-Onset Pls Motor Neuron Disease Pls Pls - [Primary Lateral Sclerosis] Lateral Spinal Sclerosis Lateral Complete Paralysis Lateral Incomplete Paralysis Lateral Paralysis
Alzheimer Disease 11	Ad11 Alzheimer'S Disease 11 Alzheimer Disease, Familial, 11 Alzheimer Disease-11 Alzheimer'S Disease 11, Late Onset
Anterior Cerebral Artery Infarction	Infarction, Anterior Cerebral Artery
Cerebral Amyloid Angiopathy, Cst3-Related	Cerebral Amyloid Angiopathy Hereditary Cerebral Hemorrhage With Amyloidosis Hchwa Hereditary Cystatin C Amyloid Angiopathy Cerebral Amyloid Angiopathy, Familial Amyloidosis, Cerebroarterial, Icelandic Type Amyloidosis Vi Cerebral Hemorrhage, Hereditary, With Amyloidosis Cst3-Related Cerebral Amyloid Angiopathy Cerebral Hemorrhage, Hereditary, With Amyloidosis, Icelandic Variant Hereditary Cerebral Hemorrhage With Amyloidosis, Icelandic Variant Caa, Familial Cerebral Amyloid Angiopathy, Genetic Acys Amyloidosis Cst3-Related Amyloidosis Cystatin Amyloidosis Hchwa, Icelandic Type Hereditary Cerebral Hemorrhage With Amyloidosis, Icelandic Type Amyloidosis 6 AMYL6 Acys Caa Cerebral Amyloid Angiopathy Cst3-Related Cerebroarterial Amyloidosis Icelandic Type Cystatin C Amyloidosis Hccaa Hchwai Hchwa-I Hereditary Cerebral Hemorrhage With Amyloidosis Icelandic Type Cerebral Amyloid Angiopathy Familial Angiopathy, Amyloid, Cerebral, Cst3-Related Hereditary Cerebral Amyloid Angiopathy, Icelandic Type Familial Cerebral Amyloid Angiopathy Cerebral Amyloid Angiopathy, Hereditary
Pick Disease Of Brain	Pick Disease Pick'S Disease Pick Disease Of The Brain Lobar Atrophy Of Brain Dementia With Lobar Atrophy And Neuronal Cytoplasmic Inclusions Behavioral Variant Of Frontotemporal Dementia Dementia In Pick'S Disease Lobar Atrophy Of The Brain Bvftd Bv-Ftd PIDB Picks Disease
Supranuclear Palsy, Progressive, 1	Progressive Supranuclear Palsy Steele-Richardson-Olszewski Syndrome Supranuclear Palsy, Progressive Progressive Supranuclear Ophthalmoplegia Psp PSNP1 Familial Progressive Supranuclear Palsy Richardson'S Syndrome Psp Syndrome Progressive Supranuclear Palsy 1 Supranuclear Palsy Progressive Ophthalmoplegia, Supranuclear, Progressive Steele-Richardson-Olszewksi Syndrome
Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex 1	Guam Disease Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex Of Guam Als-Pdc Lytico-Bodig Disease Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex 1, Susceptibility To Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex, Susceptibility To Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Of Guam Syndrome Parkinsonism-Dementia-Als Complex Pdals Amyotrophic Lateral Sclerosis, Parkinsonism/Dementia Complex Of Guam Parkinson-Dementia Complex Of Guam G-Pdc Guam Parkinsonism-Dementia Complex ALS-PDC1 Als/Pdc Of Guam Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic/Parkinsonism/Dementia Complex 1 Amyotrophic Lateral Sclerosis, Guam Form Parkinsonian Disorders
Mild Cognitive Impairment
Dementia, Lewy Body	Lewy Body Dementia Lewy Body Disease Diffuse Lewy Body Disease Dementia With Lewy Bodies DLB Autosomal Dominant Diffuse Lewy Body Disease Cortical Lewy Body Disease Dementia, Lewy Body, Susceptibility To Lewy Body Dementia, Susceptibility To Senile Dementia Of The Lewy Body Type Dementia Of The Lewy Body Type Lbd Diffuse Lewy Body Disease With Gaze Palsy Dysphasic Dementia Hereditary Lewy Body Type Senile Dementia Lewy Body Variant Of Alzheimer Disease Lewy Bodies Lewy Body Dlbd - [Diffuse Lewy Body Disease] Clbd - [Cortical Lewy Body Disease]
Movement Disease	Movement Disorders Movement Disorder
Focal Segmental Glomerulosclerosis	Familial Idiopathic Steroid-Resistant Nephrotic Syndrome Focal Glomerulosclerosis Fsgs Segmental Glomerulosclerosis Glomerulosclerosis, Focal Segmental Fgs Focal Glomerular Sclerosis Familial Idiopathic Nephrotic Syndrome Focal Sclerosis With Hyalinosis Glomerulosclerosis, Focal Glomerulosclerosis Focal Glomerulosclerosis, Segmental, Focal Focal Segmental Glomerulosclerosis, Not Otherwise Specified
Frontotemporal Dementia	Pallidopontonigral Degeneration Frontotemporal Lobar Degeneration Semantic Dementia FTD Frontotemporal Lobe Dementia Multiple System Tauopathy With Presenile Dementia Dementia, Frontotemporal Frontotemporal Dementia With Parkinsonism Mstd Frontotemporal Lobar Degeneration With Tau Inclusions Ftld With Tau Inclusions Dementia, Frontotemporal, With Parkinsonism Fldem Ftdp17 Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex Ddpac Wilhelmsen-Lynch Disease Wld Ppnd Dementia, Frontotemporal, With Or Without Parkinsonism Semantic Primary Progressive Aphasia Semantic Variant Ppa Wilhemsen-Lynch Disease Frontotemporal Dementia-Amyotrophic Lateral Sclerosis Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17 Ftd-Als Ftld Pick Complex Pick Disease Of The Brain Frontotemporal Dementia With Parkinsonism-17 Grn-Related Frontotemporal Dementia Frontotemporal Dementia With Motor Neuron Disease Dementia In Fronto-Temporal Lobar Degeneration Ftd - [Frontotemporal Dementia] Temple Dementia Frontal Lobe Dementia
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15944	YWHAQ Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19046	Ywhaq Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25536	Ywhaq Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	YWHAQ	VGNC	VGNC:81261
Bos taurus	YWHAQ	VGNC	VGNC:37047
Rattus norvegicus	YWHAQ	RGD	RGD:3979
Mus musculus	YWHAQ	MGD	MGI:891963
Others	YWHAQ	NCBI