CDK14 - cyclin dependent kinase 14 Gene

Also Known as PFTK1; PFTAIRE1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5218

About CDK14

Cytogenetic location: 7q21.13 Genomic coordinates (GRCh38): 7:90,596,321-91,210,590 (from NCBI)

This gene has 15 transcripts (splice variants), 201 orthologues and 26 paralogues. Ubiquitous expression in brain (RPKM 6.5), kidney (RPKM 3.1) and 24 other tissues.

Summary

PFTK1 is a member of the CDC2 (MIM 116940)-related protein kinase family (Yang and Chen, 2001 [PubMed 11313143]).[supplied by OMIM, Mar 2008]

CDK14 Products (4)

mRNA Protein Name
NM_001287136.1 NP_001274065.1 cyclin-dependent kinase 14 isoform c
NM_001287137.1 NP_001274066.1 cyclin-dependent kinase 14 isoform d
NM_001287135.2 NP_001274064.1 cyclin-dependent kinase 14 isoform a
NM_012395.3 NP_036527.1 cyclin-dependent kinase 14 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cyclin binding IPI
IPI: Inferred from physical interaction
19524571 GOA
enables cyclin-dependent protein serine/threonine kinase activity IMP
IMP: Inferred from mutant phenotype
19524571 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16775625 GOA
Biological Process GO Annotation Evidence References Source
involved in G2/M transition of mitotic cell cycle IDA
IDA: Inferred from direct assay
20059949 GOA
involved in regulation of canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
20059949 GOA
Cellular Component GO Annotation Evidence References Source
part of cyclin-dependent protein kinase holoenzyme complex IPI
IPI: Inferred from physical interaction
19524571 GOA
part of cytoplasmic cyclin-dependent protein kinase holoenzyme complex IDA
IDA: Inferred from direct assay
19524571 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
19524571 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDK14 Protein Structure

Pkinase

Pkinase: Protein kinase domain (135 - 419)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 469 a.a.
Protein Preferred Names Protein Names

cyclin-dependent kinase 14

  • PFTAIRE protein kinase 1

  • cell division protein kinase 14

  • serine/threonine-protein kinase PFTAIRE-1

CDK14 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CDK14 O94921 CCNY Homo sapiens Q8ND76
Y2H
19524571
Intra
CDK14 O94921 CCNY Homo sapiens Q8ND76
Anti Tag CoIP
19524571
Intra
CDK14 O94921 CCNY Homo sapiens Q8ND76
IF
19524571
Intra
CDK14 O94921 YWHAH Homo sapiens Q04917
Anti Tag CoIP
16775625
Intra
CDK14 O94921 YWHAH Homo sapiens Q04917
Y2H
16775625
Intra
CDK14 O94921 YWHAH Homo sapiens Q04917
Anti Tag CoIP
33961781
Intra
CDK14 O94921 YWHAE Homo sapiens P62258
Y2H
16775625
Intra
CDK14 O94921 YWHAE Homo sapiens P62258
Anti Tag CoIP
16775625
Intra
CDK14 O94921 YWHAB Homo sapiens P31946
Anti Tag CoIP
16775625
Intra
CDK14 O94921 YWHAB Homo sapiens P31946
Y2H
16775625
Intra
CDK14 O94921 YWHAQ Homo sapiens P27348
Y2H
16775625
Intra
CDK14 O94921 CCND3 Homo sapiens P30281
Y2H
17517622
Intra
CDK14 O94921 CCND3 Homo sapiens P30281
Anti Bait CoIP
17517622
Intra
CDK14 O94921 CCND3 Homo sapiens P30281
Anti Tag CoIP
17517622
Intra
CDK14 O94921 CDKN1A Homo sapiens P38936
Anti Bait CoIP
17517622
Intra
CDK14 O94921 CDKN1A Homo sapiens P38936
TAP
23602568
Intra
CDK14 O94921 CDKN1A Homo sapiens P38936
Anti Tag CoIP
33961781
Intra
CDK14 O94921 CDKN1A Homo sapiens P38936
Anti Tag CoIP
17517622
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-X0009 Tambiciclib Inhibitor 99.68% Phase 2
HY-X0009A Tambiciclib dimaleate Inhibitor 99.53% Phase 2

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-127104 FMF-04-159-2 Inhibitor 99.64% Unkown
HY-X0150 JSH-150 Inhibitor 98.36% Unkown
HY-137342 SB1-G-187 Degrader 98.70% Unkown
HY-160213 JA397 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus CDK14 VGNC VGNC:106680
Canis familiaris CDK14 VGNC VGNC:39046
Rattus norvegicus CDK14 RGD RGD:1305544
Macaca mulatta CDK14 VGNC VGNC:71164
Mus musculus CDK14 MGD MGI:894318
Felis catus CDK14 VGNC VGNC:68810
Others CDK14 NCBI