PI4KB - phosphatidylinositol 4-kinase beta Gene

Also Known as NPIK; PI4K92; PIK4CB; PI4KIII; PI4KBETA; PI4K-BETA; PI4KIIIBETA

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5298

About PI4KB

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:151,291,797-151,327,715 (from NCBI)

This gene has 13 transcripts (splice variants), 213 orthologues and 9 paralogues. Ubiquitous expression in thyroid (RPKM 18.9), testis (RPKM 17.6) and 25 other tissues.

Summary

Enables 1-phosphatidylinositol 4-kinase activity and 14-3-3 protein binding activity. Predicted to be involved in phosphatidylinositol phosphate biosynthetic process and phosphatidylinositol-mediated signaling. Located in Golgi membrane. [provided by Alliance of Genome Resources, Apr 2022]

PI4KB Products (15)

mRNA Protein Name
XM_011509634.2 XP_011507936.1 phosphatidylinositol 4-kinase beta isoform X1
NM_001198774.2 NP_001185703.1 phosphatidylinositol 4-kinase beta isoform 2
NM_001369628.1 NP_001356557.1 phosphatidylinositol 4-kinase beta isoform 8
NM_002651.4 NP_002642.1 phosphatidylinositol 4-kinase beta isoform 1
NM_001198775.3 NP_001185704.1 phosphatidylinositol 4-kinase beta isoform 3
XM_047422590.1 XP_047278546.1 phosphatidylinositol 4-kinase beta isoform X3
NM_001369629.2 NP_001356558.1 phosphatidylinositol 4-kinase beta isoform 5
XM_017001488.2 XP_016856977.1 phosphatidylinositol 4-kinase beta isoform X2
NM_001369623.2 NP_001356552.1 phosphatidylinositol 4-kinase beta isoform 5
NM_001330721.2 NP_001317650.1 phosphatidylinositol 4-kinase beta isoform 5
NM_001369625.1 NP_001356554.1 phosphatidylinositol 4-kinase beta isoform 6
NM_001198773.3 NP_001185702.1 phosphatidylinositol 4-kinase beta isoform 2
NM_001369624.1 NP_001356553.1 phosphatidylinositol 4-kinase beta isoform 2
NM_001369626.1 NP_001356555.1 phosphatidylinositol 4-kinase beta isoform 7
XM_017001486.2 XP_016856975.1 phosphatidylinositol 4-kinase beta isoform X2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 1-phosphatidylinositol 4-kinase activity IDA
IDA: Inferred from direct assay
11277933 GOA
enables 14-3-3 protein binding IDA
IDA: Inferred from direct assay
23572552 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16912074 GOA
Biological Process GO Annotation Evidence References Source
involved in inner ear development IMP
IMP: Inferred from mutant phenotype
33358777 GOA
acts upstream of or within lysosome organization IDA
IDA: Inferred from direct assay
25365221 GOA
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
25365221 GOA
located in Golgi membrane IDA
IDA: Inferred from direct assay
27009356 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PI4KB Protein Structure

PI3_PI4_kinase

PI3_PI4_kinase: Phosphatidylinositol 3- and 4-kinase (561 - 754)

  • 0
  • 200
  • 400
  • 600
  • 816 a.a.
Protein Preferred Names Protein Names

phosphatidylinositol 4-kinase beta

  • PtdIns 4-kinase beta

  • phosphatidylinositol 4-kinase, catalytic, beta

  • phosphatidylinositol 4-kinase, wortmannin-sensitive

  • type III phosphatidylinositol 4-kinase beta

PI4KB Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PI4KB Q9UBF8 ACBD3 Homo sapiens Q9H3P7
Y2H
22124328
Intra
PI4KB Q9UBF8 ACBD3 Homo sapiens Q9H3P7
Anti Tag CoIP
22124328
Intra
PI4KB Q9UBF8 YWHAQ Homo sapiens P27348
Pull Down
16912074
Intra
PI4KB Q9UBF8 YWHAQ Homo sapiens P27348
CoIP
15324660
Cross
PI4KB Q9UBF8 P03300-PRO_0000424692 Poliovirus type 1 P03300-PRO_0000424692
Pull Down
23572552
Cross
PI4KB Q9UBF8 NS Influenza A virus P03495
Pull Down
24008843
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Joubert Syndrome 1

  • Joubert Syndrome

  • Jbts

  • Cerebellooculorenal Syndrome 1

  • JBTS1

  • Joubert-Boltshauser Syndrome

  • Cerebelloparenchymal Disorder Iv

  • Cpd4

  • Cors1

  • Joubert Syndrome And Related Disorders

  • Jsrd

  • Familial Aplasia Of The Vermis

  • Joubert Syndrome Related Disorders

  • Js

  • Cerebellar Vermis Agenesis

  • Cerebelloparenchymal Disorder 4

  • Agenesis Of Cerebellar Vermis

  • Cerebello-Oculo-Renal Syndrome

  • Cors

  • Joubert-Bolthauser Syndrome

  • Cpd Iv

  • Classic Joubert Syndrome

  • Joubert Syndrome Type A

  • Pure Joubert Syndrome

  • Cerebello-Oculo-Renal Syndrome 1

  • Joubert Syndrome-1

  • Joubert Syndrome, Type 1

  • Joubert'S Syndrome
Nonparalytic Poliomyelitis

  • Acute Nonparalytic Poliomyelitis

  • Non-Paralytic Aseptic Meningitis
Mouth Disease

  • Mouth Diseases

  • Mouth Disorders
Lowe Oculocerebrorenal Syndrome

  • Lowe Syndrome

  • Oculocerebrorenal Syndrome

  • OCRL

  • Oculocerebrorenal Syndrome Of Lowe

  • Ocrl1

  • Phosphatidylinositol 4,5-Bisphosphate 5-Phosphatase Deficiency

  • Lowe Disease

  • Phosphatidylinositol 4,5-Biphosphate 5-Phosphatase Deficiency

  • Cerebrooculorenal Syndrome

  • Phosphatidylinositol-4,5-Bisphosphate-5-Phosphatase Deficiency

  • Lowe Oculo-Cerebro-Renal Dystrophy

  • Lowe Oculo-Cerebro-Renal Syndrome

  • Lowe Oculocerebrorenal Dystrophy

  • Low

  • Chromosome 11p Deletion Syndrome

  • Oculocerebrorenal Dystrophy

  • Cerebro-Oculorenal Dystrophy

  • Ocrl1 - [Oculocerebrorenal Syndrome]

  • Lowe-Terrey-Maclachlan Syndrome

  • Renal-Oculocerebrodystrophy
Poliomyelitis

  • Infantile Paralysis

  • Polio
Acute Flaccid Myelitis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (13)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-100603 GSK-F1 Inhibitor 95.06% Unkown
HY-108313 T-00127_HEV1 Inhibitor 99.97% Unkown
HY-22055B AN-12-H5 intermediate-1 99.72% Unkown
HY-W047496 AN-12-H5 intermediate-2 97.0% Unkown
HY-120900 AN-12-H5 Inhibitor 98.03% Unkown
HY-RS10470 Pi4kb Mouse Pre-designed siRNA Set A / Unkown
HY-177725 MG degrader 2 Degrader / Unkown
HY-182721 Pipinib / Unkown
HY-RS10469 PI4KB Human Pre-designed siRNA Set A / Unkown
HY-RS10471 Pi4kb Rat Pre-designed siRNA Set A / Unkown
HY-100603B (R)-GSK-F1 Inhibitor / Unkown
HY-175557 PI4K-IN-2 Inhibitor / Unkown
HY-W451820 AN-12-H5 intermediate-3 95.82% Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta PI4KB VGNC VGNC:76000
Canis familiaris PI4KB VGNC VGNC:44517
Bos taurus PI4KB VGNC VGNC:32854
Felis catus PI4KB VGNC VGNC:68860
Rattus norvegicus PI4KB RGD RGD:621214
Mus musculus PI4KB MGD MGI:1334433
Others PI4KB NCBI