S100A1 - S100 calcium binding protein A1 Gene

Also Known as S100; S100A; S100-alpha

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6271

About S100A1

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:153,628,434-153,632,039 (from NCBI)

This gene has 5 transcripts (splice variants), 201 orthologues and 21 paralogues. Biased expression in heart (RPKM 773.3), salivary gland (RPKM 114.1) and 3 other tissues.

Summary

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C-mediated phosphorylation. Reduced expression of this protein has been implicated in cardiomyopathies. [provided by RefSeq, Jul 2008]

S100A1 Products (1)

mRNA	Protein	Name
NM_006271.2	NP_006262.1	protein S100-A1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATPase binding	IPI IPI: Inferred from physical interaction	12804600	GOA
enables S100 protein binding	IPI IPI: Inferred from physical interaction	10913138	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	10913138	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10913138	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	10913138	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of nitric-oxide synthase activity	IDA IDA: Inferred from direct assay	24244340	GOA
involved in positive regulation of sprouting angiogenesis	IDA IDA: Inferred from direct assay	24244340	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	12118070	GOA
located in sarcoplasmic reticulum	IDA IDA: Inferred from direct assay	12804600	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

S100A1 Protein Structure

S_100

EF-hand_1

0
94 a.a.

Protein Preferred Names	Protein Names
protein S100-A1	S-100 protein alpha chain

S100A1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	S100A1	P23297	S100A3	Homo sapiens	P33764	Y2H Array	32296183
Intra	S100A1	P23297	S100A3	Homo sapiens	P33764	Validated Y2H	32296183
Intra	S100A1	P23297	S100A3	Homo sapiens	P33764	Y2H Prey Pooling	32296183
Intra	S100A1	P23297	S100Z	Homo sapiens	Q8WXG8	Y2H Array	32296183
Intra	S100A1	P23297	S100Z	Homo sapiens	Q8WXG8	Y2H Prey Pooling	32296183
Intra	S100A1	P23297	S100Z	Homo sapiens	Q8WXG8	Validated Y2H	32296183
Intra	S100A1	P23297	SLC8A1	Homo sapiens	P32418	FPS	31837246
Intra	S100A1	P23297	SLC8A1	Homo sapiens	P32418	ITC	31837246
Intra	S100A1	P23297	MYH9	Homo sapiens	P35579	FPS	31837246
Intra	S100A1	P23297	MYH9	Homo sapiens	P35579	ITC	31837246
Intra	S100A1	P23297	CAPZA1	Homo sapiens	P52907	FPS	31837246
Intra	S100A1	P23297	TP53	Homo sapiens	P04637	GMS	20591429
Intra	S100A1	P23297	TP53	Homo sapiens	P04637	FPS	31837246
Intra	S100A1	P23297	MDM2	Homo sapiens	Q00987	SPR	20591429
Intra	S100A1	P23297	MDM4	Homo sapiens	O15151	FPS	31837246
Intra	S100A1	P23297	S100B	Homo sapiens	P04271	MAPPIT	25416956
Intra	S100A1	P23297	S100B	Homo sapiens	P04271	Y2H Pooling	16189514
Intra	S100A1	P23297	S100B	Homo sapiens	P04271	Lumier	29997244
Intra	S100A1	P23297	S100B	Homo sapiens	P04271	BRET	29997244
Intra	S100A1	P23297	S100B	Homo sapiens	P04271	Y2H	10913138
Intra	S100A1	P23297	S100B	Homo sapiens	P04271	Y2H	21516116
Intra	S100A1	P23297	S100B	Homo sapiens	P04271	Lumier	32814053
Intra	S100A1	P23297	S100B	Homo sapiens	P04271	Y2H Prey Pooling	25416956
Intra	S100A1	P23297	S100A4	Homo sapiens	P26447	Y2H Pooling	16189514
Intra	S100A1	P23297	S100A4	Homo sapiens	P26447	Validated Y2H	32296183
Intra	S100A1	P23297	BEX3	Homo sapiens	Q00994	Validated Y2H	32296183
Intra	S100A1	P23297	PLEKHF2	Homo sapiens	Q9H8W4	Validated Y2H	25416956
Intra	S100A1	P23297	S100P	Homo sapiens	P25815	Y2H Array	32296183
Intra	S100A1	P23297	S100P	Homo sapiens	P25815	SPR	15171681
Intra	S100A1	P23297	S100P	Homo sapiens	P25815	Y2H Prey Pooling	32296183
Intra	S100A1	P23297	S100P	Homo sapiens	P25815	Y2H Pooling	16189514
Intra	S100A1	P23297	S100P	Homo sapiens	P25815	Y2H	15171681
Intra	S100A1	P23297	S100P	Homo sapiens	P25815	Validated Y2H	32296183
Intra	S100A1	P23297	OPTN	Homo sapiens	Q96CV9	Validated Y2H	32814053
Intra	S100A1	P23297	OPTN	Homo sapiens	Q96CV9	Y2H Pooling	32814053
Intra	S100A1	P23297	OPTN	Homo sapiens	Q96CV9	Y2H Array	32814053
Intra	S100A1	P23297	S100A2	Homo sapiens	P29034	Y2H Array	32296183
Intra	S100A1	P23297	S100A2	Homo sapiens	P29034	Validated Y2H	32296183
Intra	S100A1	P23297	S100A2	Homo sapiens	P29034	Y2H Prey Pooling	32296183
Intra	S100A1	P23297	S100A2	Homo sapiens	P29034	Y2H Array	31515488
Intra	S100A1	P23297	S100A2	Homo sapiens	P29034	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant S100A1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72783	S100A1 Protein, Human (His)	P23297 (M1-S94)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P74588	S100A1 Protein, Human (HEK293, hFc)	NP_006262.1 (G2-S94)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P74589	S100A1 Protein, Human	P23297 (M1-S94)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P72783A	S100A1 Protein, Human (C-His)	P23297 (M1-S94)	≥ 95%, as determined by reducing SDS-PAGE.

S100A1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83571	S100 alpha Antibody (YA3316)	WB, IHC-P, IP, FC	Human, Mouse
HY-P85361	S100 alpha Antibody (YA5053)	WB; IHC-P; IF-Tissue; IHC-F	Human, Mouse
HY-P86003	S100 alpha Antibody (YA5695)	IHC-P, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Malignant Peripheral Nerve Sheath Tumor	Mpnst Malignant Neurilemmoma Neurofibrosarcoma Malignant Neurofibroma Malignant Schwannoma Neurogenic Sarcoma Schwannoma, Malignant Malignant Neoplasm Of The Peripheral Nerve Sheath Malignant Peripheral Nerve Sheath Tumors
Myoepithelioma	Benign Myoepithelioma Myoepithelial Adenoma Myoepithelial Neoplasm Malignant Myoepithelioma
Epidermoid Cysts	Epidermoid Cyst Sebaceous Cyst Epidermal Inclusion Cyst Epidermal Cyst
Syringoma	Syringomas
Angiomyolipoma	Angiomyolipoma Of Kidney
Oncocytoma	Oxyphilic Adenoma Follicular Adenoma, Oxyphilic Cell Adenoma, Oxyphilic Hurthle Cell Tumor Oncocytic Neoplasm
Glomus Tumor	Glomus Neoplasm Glomus Tumour
Leiomyoma	Leiomyomatous Neoplasm Leiomyomatous Tumor Leiomyomas Fibroid Tumor Uterine Fibroids
Myxosarcoma
Fibroma
Granular Cell Tumor	Abrikosov'S Tumor Neoplasm Of Granular Cell Abrikosoff'S Granulous Cell Tumor Abrikosoff'S Tumor Giant Granulocellular Abrikosov'S Tumor Malignant Variant Of Abrikosov'S Tumor Carcinoma, Granular Cell
Chordoma	CHDM Notochordoma Notochordal Sarcoma Chordoma, Susceptibility To Chordocarcinoma Chordoepithelioma
Dermatofibrosarcoma Protuberans	DFSP Dermatofibrosarcoma Giant Cell Fibroblastoma Metastatic Dermatofibrosarcoma Protuberans Familial Dermatofibrosarcoma Protuberans Darier-Ferrand Tumor Darier-Hoffmann Tumor
Leiomyosarcoma	Leiomyosarcomas
Gastrointestinal Stromal Tumor	GIST Gastrointestinal Stromal Tumors Gastrointestinal Stromal Sarcoma Gastrointestinal Stromal Tumor, Familial Gant Gastrointestinal Stromal Tumour Stromal Tumor Of Gastrointestinal Tract Stromal Tumour Of Gastrointestinal Tract Gastrointestinal Stromal Neoplasm Paraganglioma And Gastric Stromal Sarcoma Plexosarcoma
Carcinosarcoma	Mixed Tumor, Mullerian Malignant Mixed Mesodermal Tumor Malignant Mixed Mullerian Tumor Mmmt Mixed Tumor, Mesodermal Mesodermal Mixed Tumor Mixed Mesodermal Tumor Mullerian Mixed Tumor Mixed Mullerian Tumor Malignant Mixed Müllerian Tumor Mixed Müllerian Tumor Mixed Tumor Mullerian Mixed Tumor, Not Otherwise Specified
Chondromyxoid Fibroma	Fibroma Chondromyxoid
Chondrosarcoma	Cartilaginous Cancer Chondrosarcoma Of Bone Primary Chondrosarcoma Of The Bone CHDSA
Neurilemmoma	Schwannoma Benign Schwannoma Neurilemoma Peripheral Fibroblastoma Psammomatous Schwannoma Neurolemmoma Schwannomas
Papillary Carcinoma	Carcinoma, Papillary Carcinoma Papillary
Myofibroma	Lipoleiomyoma Uterine Fibroids Solitary Myofibromatosis Myolipoma
Smooth Muscle Tumor
Renal Oncocytoma	Oncocytoma, Renal Oncocytoma Of Kidney Renal Epithelial Oncocytic Tumor Oncocytoma Kidney Oncocytoma Renal Kidney Oncocytoma
Eosinophilic Variant Of Chromophobe Renal Cell Carcinoma
Neurofibroma	Neurofibromas Neurofibromatoses Nerve Sheath Tumors
Chondroma	Central Chondroma Enchondroma
Mucoepidermoid Carcinoma	Mec Salivary Gland Mucoepidermoid Carcinoma C3772 Carcinoma Mucoepidermoid Carcinoma, Mucoepidermoid
Conjunctival Intraepithelial Neoplasm	Intraepithelial Neoplasia Of Conjunctiva Conjunctival Intraepithelial Neoplasia
Cutaneous Fibrous Histiocytoma	Dermatofibroma Fibrohistiocytic Tumor Benign Cutaneous Fibrous Histiocytoma Fibrous Histiocytoma Of Skin Fibrous Xanthoma Of Skin Pleomorphic Fibroma Sclerosing Angioma Sclerosing Angioma Of Skin Fibrous Histiocytoma
Lipomatosis, Multiple	Lipoma Familial Multiple Lipomatosis Lipomatosis, Familial Multiple Benign Lipomatous Tumor Lipomatous Neoplasm Multiple Lipomatosis Fml Lipo Benign Tumor Of Adipose Tissue Lipomatous Tumor Tumor Of Adipose Tissue Neoplasms, Adipose Tissue Lipomas
Pleomorphic Adenoma	Mixed Tumor Of The Salivary Gland Adenoma Pleomorphic Adenoma, Pleomorphic Mixed Salivary Gland Tumor Mixed Tumor, Not Otherwise Specified
Cholesteatoma Of Middle Ear	Cholesteatoma Epidermosis Of Ear Epidermosis Of Middle Ear Middle Ear Cholesteatoma Cholesteatoma Of Middle Ear And Mastoid Cholesteatoma Of Middle Ear And/Or Mastoid Cholesteatoma Of The Middle Ear Congenital Cholesteatoma Primary Acquired Cholesteatoma Secondary Acquired Cholesteatoma Cholesteatoma Middle Ear Cholesteatoma, Middle Ear Cholesterolosis Of Middle Ear Cholesterosis Of Ear Cholesterosis Of Middle Ear Cholesteatoma Nos Epidermoid Cholesteatoma Middle Ear Granuloma
Sarcoma	Connective And Soft Tissue Neoplasm Tumor Of Soft Tissue And Skeleton Sarcomas Sarcoma - Category
Rhabdomyosarcoma
Chondroblastoma	Chondroblastoma Of Bone
Melanoma In Congenital Melanocytic Nevus	Malignant Melanoma In Congenital Melanocytic Nevus Melanocytic Nevi Nevi Melanocytic
Pulmonary Blastoma	Blastoma Of Lung Pneumoblastoma
Renal Cell Carcinoma, Nonpapillary	Renal Cell Carcinoma RCC Nonpapillary Renal Cell Carcinoma Clear Cell Renal Cell Carcinoma Hypernephroma Adenocarcinoma Of Kidney Renal Carcinoma, Chromophobe, Somatic Clear Cell Carcinoma Of Kidney Clear-Cell Metastatic Renal Cell Carcinoma Clear Cell Renal Carcinoma Renal Cell Carcinoma, Somatic Conventional Renal Cell Carcinoma Conventional Renal Cell Carcinoma Renal Clear Cell Carcinoma Ccrcc Hereditary Clear Cell Renal Cell Carcinoma Carcinoma, Renal Cell Renal Cell Carcinoma, Clear Cell, Somatic Renal Cell Carcinoma, Clear Cell Clear Cell Kidney Carcinoma Clear Cell Rcc Cystic-Multilocular Variant Clear Cell Renal Cell Adenocarcinoma Hereditary Clear Cell Renal Cell Adenocarcinoma Common Renal Cell Carcinoma Crcc Renal Cell Carcinoma Non-Papillary Carcinoma Renal Cell Renal Cell Cancer Carcinoma, Renal Cell, Nonpapillary
Nephroma	Benign Nephroma
Trachea Leiomyoma	Tracheal Neoplasms Leiomyoma Of The Trachea Tracheal Neoplasm Tracheal Leiomyoma
Clear Cell Adenoma
Fasciitis
Langerhans Cell Histiocytosis	Histiocytosis X Lch Langerhans Cell Granulomatosis Langerhans-Cell Histiocytosis Letterer-Siwe Disease Hashimoto-Pritzger Disease Histiocytosis, Langerhans-Cell Langerhan'S Cell Histiocytosis Letterer-Siwe Disease Involving Intra-Abdominal Lymph Nodes Letterer-Siwe Disease Involving Intrapelvic Lymph Nodes Letterer-Siwe Disease Involving Intrathoracic Lymph Nodes Letterer-Siwe Disease Involving Lymph Nodes Of Axilla And Upper Limb Letterer-Siwe Disease Involving Lymph Nodes Of Head, Face And Neck Letterer-Siwe Disease Involving Lymph Nodes Of Head, Face, And Neck Letterer-Siwe Disease Involving Lymph Nodes Of Inguinal Region And Lower Limb Letterer-Siwe Disease Involving Lymph Nodes Of Multiple Sites Letterer-Siwe Disease Involving Spleen Letterer-Siwe Disease Of Intra-Abdominal Lymph Nodes Letterer-Siwe Disease Of Intrapelvic Lymph Nodes Letterer-Siwe Disease Of Intrathoracic Lymph Nodes Letterer-Siwe Disease Of Lymph Nodes Of Axilla And Upper Limb Letterer-Siwe Disease Of Lymph Nodes Of Axilla And/Or Upper Limb Letterer-Siwe Disease Of Lymph Nodes Of Head, Face And Neck Letterer-Siwe Disease Of Lymph Nodes Of Head, Face And/Or Neck Letterer-Siwe Disease Of Lymph Nodes Of Inguinal Region Amd/Or Lower Limb Letterer-Siwe Disease Of Lymph Nodes Of Inguinal Region And Lower Limb Letterer-Siwe Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb Letterer-Siwe Disease Of Lymph Nodes Of Multiple Sites Letterer-Siwe Disease Of Spleen Familial Letterer-Siwe Disease Langerhans-Cell Histiocytosis Nos
Kidney Benign Neoplasm	Renal And Ureteral Tumor Benign Kidney Neoplasm
Chromophobe Renal Cell Carcinoma	Chromophobe Adenocarcinoma Chromophobe Carcinoma Of Kidney Kidney Chromophobe Renal Cell Carcinoma, Chromophobe Cell Crcc Chrcc Chromophobe Renal Cell Adenocarcinoma Chromophobe Renal Carcinoma Chromophobe Carcinoma
Myocardial Infarction	Heart Attack Myocardial Infarction, Susceptibility To Myocardial Infarction 1 Myocardial Infarction, Protection Against Myocardial Infarction, Decreased Susceptibility To Myocardial Infarction, Decreased Myocardial Infarct MCI1 Premature Myocardial Infarction Myocardial Infarction, Susceptibility To, Type 1
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Tetralogy Of Fallot	TOF Fallot Tetralogy Ventricular Septal Defect With Pulmonary Stenosis Or Atresia, Dextraposition Of Aorta, And Hypertrophy Of Right Ventricle Tetrad Of Fallot Fallot Tetrad Fallot Disease Fallot Complex Subpulmonic Stenosis, Ventricular Septal Defect, Overriding Aorta, And Right Ventricular Hypertrophy Interventricular Septal Defect With Dextroposition Of Aorta, Pulmonary Stenosis And Hypertrophy Of Right Ventricle Interventricular Septal Defect, In Tetralogy Of Fallot Ventricular Septal Defect With Obstructed Right Ventricular Outflow Tof - [Tetralogy Of Fallot] Pulmonary Atresia With Ventricular Septal Defect [Fallot Type] Pulmonary Atresia, Ventricular Septal Defect And Mapcas Pulmonary Atresia With Ventricular Septal Defect And Systemic-To-Pulmonary Collateral Arteries [Fallot Type]
Renal Cell Carcinoma, Papillary, 1	Papillary Renal Cell Carcinoma Hereditary Papillary Renal Cell Carcinoma Papillary Renal Cell Carcinoma, Sporadic Papillary Renal Cell Adenocarcinoma RCCP RCCP1 Renal Cell Carcinoma, Papillary Renal Cell Carcinoma, Papillary, 1, Familial And Somatic Chromophil Carcinoma Of Kidney Papillary Kidney Carcinoma Sporadic Papillary Renal Cell Carcinoma Chromophil Renal Cell Carcinoma Papillary Renal Carcinoma, Malignant - Papillary Renal Cell Carcinoma, Bilateral - Papillary Renal Cell Carcinoma, Familial - Papillary Renal Cell Carcinoma, Multiple - Papillary Renal Cell Carcinoma, Sporadic - Renal Adenocarcinoma Chromophil Rcc Hprcc Renal Cell Carcinoma Papillary Chromophilic Renal Cell Carcinoma Prcc Carcinoma, Renal Cell, Papillary, Type 1 Type 1 Papillary Renal Cell Carcinoma Renal Cell Carcinoma Hereditary Papillary Renal Carcinoma
Interstitial Lung Disease 2	Idiopathic Pulmonary Fibrosis Ipf Fibrocystic Pulmonary Dysplasia Pulmonary Fibrosis, Idiopathic Pulmonary Fibrosis, Idiopathic, Susceptibility To Cryptogenic Fibrosing Alveolitis ILD2 Idiopathic Pulmonary Fibrosis, Familial Fibrosing Alveolitis, Cryptogenic Uip Fibrosing Alveolitis Interstitial Pneumonitis, Usual Familial Idiopathic Pulmonary Fibrosis Idiopathic Fibrosing Alveolitis, Chronic Form Usual Interstitial Pneumonia Fibrosing Alveolitis Cryptogenic Hamman-Rich Disease Idiopathic Pulmonary Fibrosis Familial Interstitial Pneumonitis Usual Fibrosis Idiopathic Pulmonary Fibrosis, Pulmonary, Idiopathic Hamman-Rich Syndrome Chronic Idiopathic Pulmonary Fibrosis Acute Interstitial Pneumonia Interstitial Pulmonary Fibrosis Ipf - [Idiopathic Pulmonary Fibrosis] Idiopathic Lung Fibrosis Fibrosing Lung Disease Pulmonary Fibrosis Nos Fibrosing Pneumonitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-146695	S100P-IN-1	Inhibitor	99.81%	Unkown
HY-103636	PROTAC Sirt2 Degrader-1	Inhibitor	99.09%	Unkown
HY-16918A	Heptamidine dimethanesulfonate	Inhibitor	99.12%	Unkown
HY-RS16310	S100a1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-16918	Heptamidine		/	Unkown
HY-RS12371	S100A1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-103636R	PROTAC Sirt2 Degrader-1 (Standard)	Inhibitor	/	Unkown
HY-RS18011	S100a1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25212	S100a13 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	S100A1	VGNC	VGNC:34236
Felis catus	S100A1	VGNC	VGNC:64838
Mus musculus	S100A1	MGD	MGI:1338917
Rattus norvegicus	S100A1	RGD	RGD:3614
Others	S100A1	NCBI