S100 alpha Antibody (YA5053)
(Synonyms: S100A1; S100A; Protein S100-A1; S-100 protein alpha chain; S-100 protein subunit alpha; S100 calcium-binding protein A1)S100 alpha Antibody (YA5053) is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to S100 alpha.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB; IHC-P; IF-Tissue; IHC-F
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Reactivity :
Human, Mouse
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Formulation:
Supplied in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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IF-Tissue
IF-Tissue: Immunofluorescence-Tissue
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IHC-F
IHC-F: Immunohistochemistry-Frozen
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|---|---|---|---|---|
| Dilution Ratio | 1:500-2000 | 1:100-500 | 1:100-500 | 1:100-500 |
Product Details
S100 alpha Antibody (YA5053) is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to S100 alpha.
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Host Rabbit
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Clonality Monoclonal,Recombinant
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Species ReactivityHuman, Mouse
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Calculated Molecular Weight Predicted band size: 11 kDa;
A synthesized peptide derived from human S100A1. The exact sequence is proprietary to MCE.
Endogenous
affinity purified by Protein A
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
S100 alpha is a Small calcium binding protein that plays important roles in several biological processes such as Ca(2+) homeostasis, chondrocyte biology and cardiomyocyte regulation. In response to an increase in intracellular Ca(2+) levels, binds calcium which triggers conformational changes. These changes allow interactions with specific target proteins and modulate their activity. Regulates a network in cardiomyocytes controlling sarcoplasmic reticulum Ca(2+) cycling and mitochondrial function through interaction with the ryanodine receptors RYR1 and RYR2, sarcoplasmic reticulum Ca(2+)-ATPase/ATP2A2 and mitochondrial F1-ATPase. Facilitates diastolic Ca(2+) dissociation and myofilament mechanics in order to improve relaxation during diastole[1][2][3][4].
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Subcellular Localization
Cytoplasm; Sarcoplasmic reticulum; Mitochondrion
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Expression
Tissue_specificity:It is abundant in the heart (PubMed: 12804600, PubMed: 1384693) . Small amounts have also been found in skeletal muscle and the brain (PubMed: 1384693) . -
Subunit
Dimer of either two alpha chains, or two beta chains, or one alpha and one beta chain (PubMed:21296671). Also forms heterodimers with S100P (PubMed:15171681).
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SwissProt ID
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Synonyms
S100A1; S100A; Protein S100-A1; S-100 protein alpha chain; S-100 protein subunit alpha; S100 calcium-binding protein A1
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