Tlr9 - toll-like receptor 9 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 81897

About Tlr9

Chromosome 9: 106,099,797-106,104,082 forward strand.GRCm39:CM001002.3

This gene has 1 transcript (splice variant), 81 orthologues, 24 paralogues and is associated with 24 phenotypes. Biased expression in spleen adult (RPKM 37.8), mammary gland adult (RPKM 11.5) and 5 other tissues.

Summary

Predicted to enable interleukin-1 receptor binding activity; pattern recognition receptor activity; and siRNA binding activity. Involved in several processes, including positive regulation of cytokine production; regulation of defense response; and regulation of macromolecule biosynthetic process. Acts upstream of or within several processes, including cellular response to chloroquine; negative regulation of ERK1 and ERK2 cascade; and regulation of dendritic cell cytokine production. Located in cytoplasmic vesicle; endoplasmic reticulum; and plasma membrane. Is expressed in intestine and small intestine mucosa. Human ortholog(s) of this gene implicated in several diseases, including allergic bronchopulmonary aspergillosis; cystic fibrosis; glomerulonephritis (multiple); hepatitis B; and lung disease (multiple). Orthologous to human TLR9 (toll like receptor 9). [provided by Alliance of Genome Resources, Apr 2022]

Tlr9 Products (1)

mRNA Protein Name
NM_031178.2 NP_112455.2 toll-like receptor 9 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17452530 MGI
Biological Process GO Annotation Evidence References Source
involved in MyD88-dependent toll-like receptor signaling pathway IPI
IPI: Inferred from physical interaction
18820679 MGI
involved in activation of innate immune response IDA
IDA: Inferred from direct assay
25686612 MGI
involved in canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
18820679 MGI
acts upstream of or within cellular response to chloroquine IDA
IDA: Inferred from direct assay
17475835 MGI
acts upstream of or within defense response to virus IGI
IGI: Inferred from genetic interaction
18250457 MGI
acts upstream of or within immune response IMP
IMP: Inferred from mutant phenotype
11130078 MGI
involved in maintenance of gastrointestinal epithelium IMP
IMP: Inferred from mutant phenotype
17128265 MGI
acts upstream of or within negative regulation of ERK1 and ERK2 cascade IGI
IGI: Inferred from genetic interaction
23109291 MGI
involved in positive regulation of cytokine production IDA
IDA: Inferred from direct assay
21402738 MGI
involved in positive regulation of interferon-beta production IDA
IDA: Inferred from direct assay
15356140 MGI
involved in positive regulation of interleukin-10 production IDA
IDA: Inferred from direct assay
15356140 MGI
involved in positive regulation of interleukin-12 production IDA
IDA: Inferred from direct assay
15356140 MGI
involved in positive regulation of interleukin-18 production IDA
IDA: Inferred from direct assay
15356140 MGI
involved in positive regulation of interleukin-6 production IDA
IDA: Inferred from direct assay
15356140 MGI
involved in positive regulation of intestinal epithelial cell development IMP
IMP: Inferred from mutant phenotype
17128265 MGI
involved in positive regulation of toll-like receptor 9 signaling pathway IMP
IMP: Inferred from mutant phenotype
18931679 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
15356140 MGI
involved in positive regulation of tumor necrosis factor production IDA
IDA: Inferred from direct assay
15356140 MGI
involved in positive regulation of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
18931679 MGI
acts upstream of or within regulation of B cell activation IGI
IGI: Inferred from genetic interaction
23109291 MGI
acts upstream of or within regulation of dendritic cell cytokine production IDA
IDA: Inferred from direct assay
19047410 MGI
involved in regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
18203139 MGI
acts upstream of or within regulation of protein phosphorylation IDA
IDA: Inferred from direct assay
24740015 MGI
acts upstream of or within response to virus IMP
IMP: Inferred from mutant phenotype
14993594 MGI
Cellular Component GO Annotation Evidence References Source
located in early phagosome IDA
IDA: Inferred from direct assay
18305481 MGI
located in endolysosome IDA
IDA: Inferred from direct assay
25917084 MGI
located in endolysosome IGI
IGI: Inferred from genetic interaction
18820679 MGI
located in endolysosome IMP
IMP: Inferred from mutant phenotype
18931679 MGI
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
18305481 MGI
located in endosome IDA
IDA: Inferred from direct assay
18305481 MGI
located in lysosome IDA
IDA: Inferred from direct assay
18305481 MGI
located in phagocytic vesicle IGI
IGI: Inferred from genetic interaction
18820679 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
16415873 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Tlr9 Protein Structure

PRK15370

PRK15370: cl33128 (23 - 253)

LRR_RI

LRR_RI: sd00033 (42 - 63)

LRR_RI

LRR_RI: sd00033 (64 - 87)

LRR_RI

LRR_RI: sd00033 (124 - 167)

LRR_RI

LRR_RI: sd00033 (168 - 199)

PLN00113

PLN00113: cl33413 (198 - 650)

LRR_RI

LRR_RI: sd00033 (200 - 220)

LRR_RI

LRR_RI: sd00033 (221 - 244)

LRR_RI

LRR_RI: sd00033 (245 - 284)

LRR_RI

LRR_RI: sd00033 (285 - 308)

LRR_RI

LRR_RI: sd00033 (309 - 334)

LRR_RI

LRR_RI: sd00033 (335 - 364)

LRR_RI

LRR_RI: sd00033 (392 - 410)

LRR_12

LRR_12: pfam18837 (392 - 421)

LRR_RI

LRR_RI: sd00033 (476 - 497)

LRR_RI

LRR_RI: sd00033 (498 - 522)

LRR_RI

LRR_RI: sd00033 (523 - 546)

LRR_RI

LRR_RI: sd00033 (547 - 576)

LRR_RI

LRR_RI: sd00033 (577 - 599)

LRR_RI

LRR_RI: sd00033 (600 - 629)

LRR_8

LRR_8: cl38440 (622 - 689)

LRR_RI

LRR_RI: sd00033 (630 - 678)

LRR_RI

LRR_RI: sd00033 (679 - 702)

LRR_RI

LRR_RI: sd00033 (703 - 751)

LRR_RI

LRR_RI: sd00033 (752 - 773)

TIR_2

TIR_2: cl23749 (869 - 973)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1032 a.a.
Protein Preferred Names Protein Names

toll-like receptor 9

Tlr9 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Tlr9 Q9EQU3 Atp2a2 Rattus norvegicus P11507
Anti Tag CoIP
24610369
Cross
Tlr9 Q9EQU3 Atp2a2 Rattus norvegicus P11507
TAP
24610369
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B1370 Hydroxychloroquine sulfate Inhibitor 99.99% Yes
HY-B1370B (R)-Hydroxychloroquine Inhibitor / Unkown
HY-B1370A (S)-Hydroxychloroquine Inhibitor / Unkown

Clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Phase
HY-150218 Agatolimod sodium Agonist 99.13% Phase 3
HY-148511 Vidutolimod Agonist 93.85% Phase 3
HY-150724C ODN 1018 sodium Agonist 97.49% Phase 2
HY-177617A Bazlitoran sodium Agonist 95.30% Phase 2
HY-177617 Bazlitoran Agonist 95.30% Phase 2
HY-178166 ETI41 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (35)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-146245 ODN 1826 Agonist 99.69% Unkown
HY-146245C ODN 1826 sodium Agonist 99.51% Unkown
HY-146244 Agatolimod Agonist 98.84% Unkown
HY-150741C ODN 2216 sodium Agonist 98.57% Unkown
HY-150741 ODN 2216 Agonist 98.57% Unkown
HY-N0201 Atractylenolide I Antagonist 99.98% Unkown
HY-150724 ODN 1018 Agonist 99.28% Unkown
HY-150743 ODN 2395 Agonist 98.39% Unkown
HY-150726C ODN 1668 sodium Agonist 98.79% Unkown
HY-124603 AT791 Inhibitor 98.77% Unkown
HY-150743C ODN 2395 sodium Agonist 98.20% Unkown
HY-148045 TLR9-IN-1 Inhibitor 99.67% Unkown
HY-12756 E6446 Antagonist 98.78% Unkown
HY-150726 ODN 1668 Agonist 99.03% Unkown
HY-12756A E6446 dihydrochloride Antagonist 99.29% Unkown
HY-150750 ODN M362 Agonist 96.01% Unkown
HY-150217A CpG ODN 10101 sodium Agonist 98.84% Unkown
HY-150217 CpG ODN 10101 Agonist 99.44% Unkown
HY-B1370R Hydroxychloroquine sulfate (Standard) Inhibitor 99.96% Unkown
HY-101929 CU-CPT17e Agonist 98.67% Unkown
HY-150736 ODN 20844 Inhibitor 96.14% Unkown
HY-146245F FAM-labeled ODN 1826 sodium Agonist 98.03% Unkown
HY-114592 M199 Inhibitor 98.55% Unkown
HY-150744 ODN 24888 Inhibitor / Unkown
HY-150745 ODN 24987 Inhibitor / Unkown
HY-150212 Tilsotolimod Inhibitor 99.46% Unkown
HY-178037 TLR9 antagonist 1 Antagonist / Unkown
HY-179474 TSI-13-57 Inhibitor 98.73% Unkown
HY-150219A ODN M326 sodium Inhibitor / Unkown
HY-180507 TLR2/9 antagonist 1 Antagonist / Unkown
HY-179209 TLR9-IN-2 Inhibitor / Unkown
HY-178169 ETI60 Inhibitor 99.51% Unkown
HY-150219 ODN M326 Agonist / Unkown
HY-183079 ENDO12 Inhibitor / Unkown
HY-183400 BIM-46174 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tlr9 NCBI NCBI:54106