TLR9 - toll like receptor 9 Gene

Also Known as CD289

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 54106

About TLR9

Cytogenetic location: 3p21.2 Genomic coordinates (GRCh38): 3:52,221,080-52,225,645 (from NCBI)

This gene has 1 transcript (splice variant), 81 orthologues and 25 paralogues. Broad expression in lymph node (RPKM 2.9), spleen (RPKM 1.9) and 16 other tissues.

Summary

The protein encoded by this gene is a member of the Toll-like Receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in Bacterial DNA to mount an innate immune response. [provided by RefSeq, Aug 2017]

TLR9 Products (2)

mRNA	Protein	Name
NM_017442.4	NP_059138.1	toll-like receptor 9 precursor
NM_138688.1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables interleukin-1 receptor binding	IPI IPI: Inferred from physical interaction	12925853	GOA
enables pattern recognition receptor activity	IDA IDA: Inferred from direct assay	14716310	GOA
enables siRNA binding	IMP IMP: Inferred from mutant phenotype	15723075	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in defense response to Gram-negative bacterium	IMP IMP: Inferred from mutant phenotype	22427638	GOA
involved in detection of molecule of bacterial origin	IDA IDA: Inferred from direct assay	17128265	GOA
involved in negative regulation of ATPase-coupled calcium transmembrane transporter activity	IDA IDA: Inferred from direct assay	24610369	GOA
involved in positive regulation of B cell activation	IDA IDA: Inferred from direct assay	23857366	GOA
involved in positive regulation of B cell proliferation	IDA IDA: Inferred from direct assay	23857366	GOA
involved in positive regulation of JNK cascade	IDA IDA: Inferred from direct assay	17128265	GOA
involved in positive regulation of MAPK cascade	IDA IDA: Inferred from direct assay	23857366	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	17128265	GOA
involved in positive regulation of chemokine production	IDA IDA: Inferred from direct assay	19740627	GOA
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	24409285	GOA
involved in positive regulation of granulocyte macrophage colony-stimulating factor production	IDA IDA: Inferred from direct assay	24409285	GOA
involved in positive regulation of immunoglobulin production	IDA IDA: Inferred from direct assay	23857366	GOA
involved in positive regulation of interferon-alpha production	IDA IDA: Inferred from direct assay	16286015	GOA
involved in positive regulation of interferon-beta production	IDA IDA: Inferred from direct assay	16286015	GOA
involved in positive regulation of interleukin-6 production	IDA IDA: Inferred from direct assay	19740627	GOA
acts upstream of positive regulation of interleukin-8 production	IDA IDA: Inferred from direct assay	17128265	GOA
involved in positive regulation of interleukin-8 production	IDA IDA: Inferred from direct assay	19740627	GOA
involved in positive regulation of non-canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	19740627	GOA
involved in positive regulation of type II interferon production	IDA IDA: Inferred from direct assay	16286015	GOA
involved in regulation of B cell differentiation	IDA IDA: Inferred from direct assay	23857366	GOA
involved in toll-like receptor 9 signaling pathway	IDA IDA: Inferred from direct assay	23857366	GOA
involved in toll-like receptor signaling pathway	IDA IDA: Inferred from direct assay	17128265	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	17128265	GOA
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	17128265	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	19740627	GOA
is active in early endosome membrane	IDA IDA: Inferred from direct assay	14716310	GOA
is active in endoplasmic reticulum	IDA IDA: Inferred from direct assay	14716310	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	19740627	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TLR9 Protein Structure

LRR_8

LRR_1

LRR_8

LRR_6

LRR_8

TIR

0
200
400
600
800
1032 a.a.

Protein Preferred Names	Protein Names
toll-like receptor 9

TLR9 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83576	Toll-Like Receptor 9 Antibody (YA3321)	WB	Human
HY-P84823	Toll-Like Receptor 9 Antibody (YA4520)	IHC-P, ICC/IF, FC, ELISA	Human
HY-P84823A	Toll-Like Receptor 9 Antibody (YA4520)(PBS only)	IHC-P, ICC/IF, FC, ELISA	Human

Related Diseases

Diseases	Alias
Immune-Complex Glomerulonephritis	Immune Complex Glomerulonephritis
Behcet Syndrome	Behcet Disease Behcet'S Syndrome Behcet'S Disease Behçet Disease Bd Adamantiades-Behcet Disease Triple Symptom Complex Behet'S Syndrome Bd Syndrome Behçet Syndrome Behçet'S Disease Behçet'S Syndrome Behcet Triple Symptom Complex Malignant Aphthosis Old Silk Route Disease Adamantiades-Behçet Disease
Dermatitis	Eczema Skin Inflammation Inflammatory Dermatosis
X-Linked Immunodeficiency 74	Immunodeficiency 74, Covid-19-Related, X-Linked Imd74 Respiratory Insufficiency Due To Sars-Cov-2 Viral Infection Tlr7 Deficiency X-Linked Immunodeficiency 74,Covid-19-Related
Human Immunodeficiency Virus Infectious Disease	Hiv Infections
Visceral Leishmaniasis	Kala-Azar Leishmaniasis, Visceral Infection By Visceral Leishmaniasis Leishmaniasis Visceral Sahib Disease Ponos Burdwan Fever Mard El Bicha Sirkari Disease Indian Visceral Leishmaniasis Dumdum Fever Visceral Leishmaniasis Due To Leishmania Donovani
Molluscum Contagiosum	Water Warts Molluscum Verrucosum
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Anogenital Venereal Wart	Genital Warts Condylomata Acuminata Anogenital Warts Condyloma Acuminatum Anogenital Human Papilloma Virus Infectious Disease Genital Wart Virus Infectious Disease Venereal Wart Venereal Warts Verrucae Anogenitales Verrucae Genitales
Lyme Disease	Lyme Borreliosis Lyme Neuroborreliosis Borreliosis Borrelia Burgdorferi Infection Neuroborreliosis Bannwarth Syndrome Bannworth'S Syndrome Neurological Lyme Disease B. Burgdorferi Infection Borreliosis, Lyme Infection By Borrelia Burgdorferi Infection Due To Borrelia Burgdorferi Sensu Lato Lym Borrelia Infections
Cervicitis	Uterine Cervicitis Inflammation Of Cervix
Mycobacterium Tuberculosis 1	Tuberculosis Tuberculosis, Susceptibility To Tuberculoma Mycobacterium Tuberculosis, Susceptibility To, 1 Mtbs1 TB
Primary Bacterial Infectious Disease
Bell'S Palsy	Bell Palsy Facial Nerve Palsy Facial Palsy Facial Paralysis Bell'S Palsy Antoni'S Palsy Facial Cranial Nerve Paralysis Idiopathic Facial Palsy Refrigeration Palsy Facial Nerve Paralysis Seventh Cranial Nerve Paralysis Face Paralysis Nos
Bacterial Sepsis
Herpes Simplex	Herpes Simplex Infections Herpesvirus Hominis Disease Herpes Simplex Disease Herpesviral Infection Due To Herpes Simplex Infections Due To Simplex Virus Herpes Nos
Basal Cell Carcinoma	Basal Cell Cancer Basal Cell Neoplasm Basal Cell Carcinoma Of Skin Malignant Basal Cell Tumor Basal Cell Tumor Epithelioma Basal Cell Malignant Basal Cell Neoplasm Rodent Ulcer Carcinoma Basal Cell Neoplasms, Basal Cell Basal Cell Carcinomas Experimental Organism Basal Cell Carcinoma Nodulo-Ulcerative Basal Cell Carcinoma Basalioma Basal Cell Epithelioma Of Skin Bcc - [Basal Cell Carcinoma] Of Skin Rodent Ulcer Of Skin Rodent Ulcer Of Unspecified Site Basal Cell Epithelioma Of Unspecified Site
Viral Infectious Disease	Arbovirus Infections Viral Disease Virus Infection Virus Diseases Viral Infection Viral Infections Virus Infections
Keratoconjunctivitis
Aicardi-Goutieres Syndrome	Aicardi Goutieres Syndrome Cree Encephalitis Encephalopathy With Basal Ganglia Calcification Aicardi-Goutières Syndrome Ags Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid Pseudotoxoplasmosis Syndrome Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis Aicardi-Goutieres Syndrome 1
Leishmaniasis	Post-Kala-Azar Dermal Leishmaniasis Post Kala-Azar Dermal Leishmaniasis Post-Kala-Azar Dermal Infectious Disease By Leishmaniasis Cutaneous Leishmaniasis Kala-Azar Visceral Leishmaniasis Leishmaniasis, Cutaneous Leishmaniasis, Visceral Leishmania Leishmania Infection Leishmaniosis
Bacterial Infectious Disease	Bacterial Infections Bacterial Infection Nos Disease Caused By Bacteria Bacterial Disease Or Disorder
Dermatitis, Atopic	Atopic Dermatitis Atopic Eczema Dermatitis, Atopic, Susceptibility To, 1 Atod Eczema, Atopic Dermatitis, Atopic 1 Allergic Dermatitis Atopic Neurodermatitis Besnier'S Prurigo Dermatitis, Atopic, 1 Dermatitis Atopic Eczema Besnier Prurigo
Bronchiolitis Obliterans	Bronchiolitis Fibrosa Obliterans Obliterative Bronchiolitis Bronchiolitis Exudativa Bronchiolitis, Exudative
Opportunistic Mycosis	Opportunistic Mycoses Opportunistic Systemic Mycoses
Lymphadenitis	Acute Lymphadenitis Chronic Lymphadenitis Chronic Adenitis Acute Adenitis Adenitis Inflammation Of Lymph Node Adenitis Nos Inflammation Of Gland Lymphatic Gland Inflammation Lymph Gland Inflammation Polyadenitis Chronic Adenitis Of Any Lymph Node Except Mesenteric Chronic Lymphadenitis Except Mesenteric Chronic Non-Specific Lymphadenitis
Invasive Aspergillosis	Aspergillosis Invasive
Cowpox	Yaba
Malaria	Malaria, Susceptibility To Malaria, Resistance To Malaria, Cerebral Cerebral Malaria Malaria, Severe, Susceptibility To Malaria, Severe, Resistance To Malaria, Cerebral, Susceptibility To Induced Malaria Malaria, Vivax, Protection Against Malaria, Severe Malaria, Cerebral, Reduced Risk Of Malaria, Protection Against Resistance To Malaria Due To G6pd Deficiency Malaria Due To G6pd Deficiency Malarial Encephalitis CM Malaria Cerebral Susceptibility To Malaria Acute Pernicious Fever Aestivo-Autumnal Fever Aestivo Autumnal Malaria Chagres Fever Continued Malaria Fever Estivo-Autumnal Fever Estivo-Autumnal Malaria Estivo-Autumnal Malarial Fever Falciparum Fever Malignant Tertian Fever Malignant Tertian Malaria Pernicious Intermittent Fever Pernicious Malaria Quotidian Malaria Subtertian Fever Subtertian Malaria Fever Subtertian Malignant Tertian Malaria Tropical Malaria Algid Malaria Bilious Haemoglobinuric Fever Black Water Fever Blackwater Fever Malarial Blackwater Fever Severe Malarial Falciparum West African Fever Malarial Haematinuria Haemoglobinuric Fever Haemoglobinuric Malaria Severe Plasmodium Falciparum Malaria Malarial Haemoglobinuria Malarial Haematuria Falciparum Malaria [Malignant Tertian] Malaria Tropica Malarial Shock Chagres Virus Disease Malignant Malaria Mtm - [Malignant Tertian Malaria] Tm -[Malignant Tertian Malaria] Panama Fever St - [Subtertian Malaria] Malarial Quotidian Benign Tertian Malaria Tertian Ague Vivax Fever Plasmodium Vivax Malaria Nos Btm - [Benign Tertian Malaria] Bt - [Benign Tertian Malaria] Vivax Malaria Benign Tertian Vivax Malaria Tertian Malaria Quartan Malaria Quartan Ague Quartan Fever Plasmodium Malariae Malaria Nos Quartan Malarial Malaria By Plasmodium Malariae Malariae Malaria Ovale Tertian Malaria Plasmodium Ovale Fever Malaria Fever By Plasmodium Ovale Ovale Malaria Malaria By Plasmodium Ovale Malarial Ovale Marsh Fever Remittent Congestive Fever Coastal Fever Remittent Gastric Fever Miasmatic Fever Congestive Remittent Fever Intermittent Fever Jungle Fever Paludism Cameroon Fever Ague Corsican Fever Intermittent Bilious Fever Disease Due To Plasmodiidae Malarial Fever Plasmodiosis Remittent Fever Roman Fever Malaria Fever Nos Malaria Nos Paludal Fever Clinically Diagnosed Malaria Clinically Diagnosed Malaria Without Parasitological Confirmation Congestive Fever Malarial Cachexia Marsh Cachexia Paludal Cachexia Recurrent Malaria Remittent Malaria
Esophageal Atresia	Tracheoesophageal Fistula Congenital Atresia Of Esophagus Congenital Imperforate Esophagus Imperforate Esophagus Oesophageal Atresia Te Fistula Tef Tracheoesophageal Fistula With Or Without Esophageal Atresia
Immune Deficiency Disease	Immunodeficiency Primary Immunodeficiency Disease Primary Immunodeficiency Immunologic Deficiency Syndromes Hypoimmunity Immune Deficiency Disorder Immunodeficiency Syndrome Immune Disorder Primary Immune Deficiency Disorder Immune System Diseases Human Immunodeficiency Virus Infection Hiv - [Human Immunodeficiency Virus Infection] Hiv Positive Nos Hiv Disease Acquired Immune Deficiency Syndrome-Related Complex Aids-Like Syndrome Aids-Related Complex Nos Arc - [Aids-Related Complex] Immunodeficiency Due To Human Immunodeficiency Virus Infection Unspecified Human Immunodeficiency Virus Disease Hiv Disease Nos Human Immunodeficiency Virus Positive Nos Hiv Nos Deficiency Of Complement Initial Pathway Deficiency Of Complement Terminal Pathway Cfdd - [Complement Factor D Deficiency] Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency Nonfamilial Hypogammaglobulinaemia Common Variable Immune Deficiency Nonfamilial Agammaglobulinaemia Common Variable Agammaglobulinaemia Agammaglobulinaemia Nos Agammaglobulinaemia Antibody Deficiency Syndrome Hypogammaglobulinaemia Antibody Deficiency Syndrome Acquired Agammaglobulinaemia Nos Hypogammaglobulinaemia Nos Hyper Igm
Follicular Lymphoma	Lymphoma, Follicular Lymphoma Follicular Brill-Symmers' Disease Large Cell Follicular Non-Hodgkin Lymphoma Diffuse Follicle Centre Lymphoma Diffuse Follicular Lymphoma Nos Follicular Nodular Non-Hodgkin Lymphoma, Unspecified Follicular Large Cell Cleaved Or Noncleaved Lymphoma Large Cell Follicular Noncleaved Lymphoma Follicular Lymphoma With Or Without Diffuse Areas Histiocytic Follicular Lymphoma Histiocytic Nodular Lymphoma Histiocytic Nodular Malignant Lymphoma Large Cell Follicular Lymphoma Large Cell Noncleaved Follicular Lymphoma Large Cell Noncleaved Follicular Malignant Lymphoma Nodular Reticulum Cell Sarcoma Noncleaved Follicular Lymphoma
Commensal Bacterial Infectious Disease
Burkitt Lymphoma	Burkitt'S Lymphoma BL Burkitt Lymphoma, Somatic Burkitt Lymphoma/Leukaemia Burkitt'S Tumor Burkitt'S Tumor Or Lymphoma Malignant Lymphoma, Burkitt'S Type Small Non-Cleaved Cell Lymphoma, Burkitt'S Type Small Non-Cleaved Cell Lymphoma Burkitt Tumor Burkitts Lymphoma Lymphoma, Small Noncleaved-Cell Burkitt Tumour Diffuse Small Noncleaved Malignant Burkitt Lymphoma Malignant Burkitt Lymphoma “Burkitt-Like” Lymphoma Undifferentiated Burkitt Lymphoma Small Noncleaved Cell Burkitt Lymphoma
Skin Disease	Skin Diseases Abnormality Of The Skin Skin Diseases, Genetic Genodermatosis Skin And Subcutaneous Tissue Disease Dermatologic Disorders
Meningitis	Streptococcal Meningitis Acute Streptococcal Meningitis Staphylococcal Meningitis Adenoviral Meningitis Influenza Meningitis Influenzal Meningitis Meningitis Due To H. Influenzae Cryptococcal Meningitis Fungal Meningitis Due To Cryptococcus Neoformans Cryptococcosis Meningitis Cryptococcus Meningitis Cryptococcal Meningoencephalitis Meningitis Due To Cryptococcus Mumps Virus Meningitis Mumps Meningitis
Mucositis	Inflammatory Disease Of Mucous Membrane Gastrointestinal Mucositis
Toxoplasmosis	Disseminated Toxoplasmosis Multisystemic Disseminated Toxoplasmosis Acquired Toxoplasmosis Toxoplasmosis Disease Or Disorder Infection By Toxoplasma Gondii Toxoplasmal Toxoplasma
Filariasis	Disease Due To Superfamily Filarioidea Bancroftian Filarial Fever Mumu Wanganga Bancroftian Filariasis Wuchereriosis Brugiosis Malayan Filariasis
Fungal Infectious Disease	Mycoses Mycosis
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Celiac Disease 1	Celiac Disease Coeliac Disease Celiac Sprue Celiac Disease, Susceptibility To Gluten-Sensitive Enteropathy Nontropical Sprue Sprue CELIAC1 Celiac Disease, Susceptibility To, 1 Celiac Sprue 1 Celiac Sprue, Susceptibility To, 1 Gluten-Sensitive Enteropathy 1 Gluten-Sensitive Enteropathy, Susceptibility To, 1 Idiopathic Steatorrhea Cœliac Disease Gluten Intolerance Gluten-Induced Enteropathy Gluten Enteropathy Celiac Disease, Susceptibility To, Type 1 Childhood Celiac Disease Coeliac Rickets Gee Disease Gee-Herter Disease Heubner-Herter Disease Idiopathic Steatorrhoea Thaysen'S Disease Herter Gee Syndrome
Inhalation Anthrax	Pulmonary Anthrax Respiratory Anthrax Inhalational Anthrax Wool-Sorters' Disease Woolsorters' Disease Inhalation Anthrax Disease Respiratory Anthrax Disease
Autoimmune Disease	Autoimmune Diseases Autoimmune Hypersensitivity Disease Hypersensitivity Reaction Type Ii Disease Type Ii Hypersensitivity Reaction Disease
Colitis
Common Variable Immunodeficiency	Cvid Common Variable Agammaglobulinemia Acquired Hypogammaglobulinemia Common Variable Immune Deficiency Hypogamma-Globulinemia, Acquired Idiopathic Immunoglobulin Deficiency Primary Antibody Deficiency Primary Hypogammaglobulinemia Acquired Agammaglobulinemia Sporadic Hypogammaglobulinemia Common Variable Hypogamma-Globulinemia Immunoglobulin Deficiency, Late-Onset Common Variable Hypogammaglobulinemia Immunodeficiency, Common Variable
Disease By Infectious Agent	Infectious Disease Infectious Diseases
Meningococcal Meningitis	Meningitis, Meningococcal Meningitis Meningococcal Epidemic Meningitis Meningitis Due To Neisseria Meningitidis Meningococcal Meninges Infection Meningococcal Meningeal Infection Meningococcal Cerebrospinal Inflammation Chronic Meningococcal Arachnoiditis Meningococcal Arachnoiditis Diplococcal Spinal Meningitis Diplococcal Meningitis Meningococcal Cerebrospinal Fever Meningococcal Cerebrospinal Infection Meningococcal Spinal Meningitis
Diabetes Mellitus	Diabetes
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Psoriasis
Tonsillitis	Chronic Tonsillitis Throat Infection - Tonsillitis
Measles	Rubeola Morbilli Measles Nos Koplik Spots
Glomerulonephritis	Bright'S Disease
Erythema Nodosum
Coccidiosis	Intestinal Coccidiosis Enteric Coccidiosis
Gastroenteritis	Cholera Morbus Infectious Colitis, Enteritis And Gastroenteritis Enteritis Due To Astrovirus Rotaviral Gastroenteritis Viral Gastroenteritis Due To Rotavirus
Bronchiolitis
Leprosy 3	Leprosy Leprosy, Susceptibility To, 3 Hansen'S Disease Leprosy, Susceptibility To Hansen Disease Infection Due To Mycobacterium Leprae LPRS3 Leprosy, Type 3 Anaesthesia Leprosy Anaesthetic Leprosy Maculoanaesthetic Leprosy Macular Leprosy Leprosy Unspecified
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Salmonellosis	Salmonella Infections Salmonella Infection
Genital Herpes	Herpes Genitalis Genital Herpes Simplex Venereal Herpes Virus-Genital Herpes
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos
Primary Biliary Cholangitis	Primary Biliary Cirrhosis Biliary Liver Cirrhosis Chronic Nonsuppurative Destructive Cholangitis Familial Primary Biliary Cirrhosis Pbc Hanot Syndrome Cholestatic Cirrhosis Biliary Cirrhosis Primary Liver Cirrhosis, Biliary Hanot'S Cirrhosis Biliary Cirrhosis Pericholangiolic Biliary Cirrhosis Tannhauser-Magendantz Syndrome Hanot-Rossle Syndrome Hypertrophic Cirrhosis Todd Cirrhosis Hanot Cirrhosis Charcot Cirrhosis Mahon-Tannhauser Syndrome Toxic Cirrhosis Hypertrophic Biliary Cirrhosis Monolobular Cirrhosis Unilobar Cirrhosis Xanthomatous Biliary Cirrhosis
Actinic Keratosis	Solar Keratosis Actinic Keratosis Senile Hyperkeratosis Sk - Solar Keratosis Keratosis, Actinic Seborrheic Keratosis Ak - [Actinic Keratosis] Sk - [Solar Keratosis]
Autoimmune Disease Of Musculoskeletal System
Transvestism	Dual-Role Transvestism Fetishistic Transvestism Cross Dresser Transvestic Fetishism
Anaerobic Meningitis
Parasitic Protozoa Infectious Disease	Protozoan Infections Mastigophora Infectious Disease Sarcomastigophora Infectious Disease
Superficial Basal Cell Carcinoma	Multifocal Superficial Basal Cell Carcinoma Multicentric Basal Cell Carcinoma Superficial Multicentric Basal-Cell Carcinoma
Chilblain Lupus 1	Chilblain Lupus CHBL1 Chilblain Lupus Erythematosus Chle Hutchinson Lupus Chilblain Lupus, Type 1
Aspergillosis	Aspergillosis, Susceptibility To Infection Due To Aspergillus Aspergilloma Aspergillus Nodule Simple Aspergilloma Aspergillus Aspergillus Flavus Infection Aspergillus Fumigatus Infection Aspergillus Infection Infection By Aspergillus Fumigatus Intracavitary Aspergillus Fungus Ball Aspergillus Terreus
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Potocki-Shaffer Syndrome	Proximal 11p Deletion Syndrome Chromosome 11p11.2 Deletion Syndrome Pss 11p11.2 Deletion P11pds Defect11 Syndrome Deletion Of Chromosome 11p11.2 POSHS

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B1370	Hydroxychloroquine sulfate	Inhibitor	99.99%	Yes
HY-B1370B	(R)-Hydroxychloroquine	Inhibitor	/	Unkown
HY-B1370A	(S)-Hydroxychloroquine	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Phase
HY-150218	Agatolimod sodium	Agonist	99.13%	Phase 3
HY-148511	Vidutolimod	Agonist	93.85%	Phase 3
HY-150724C	ODN 1018 sodium	Agonist	97.49%	Phase 2
HY-177617A	Bazlitoran sodium	Agonist	95.30%	Phase 2
HY-177617	Bazlitoran	Agonist	95.30%	Phase 2
HY-178166	ETI41	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (35)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-146245	ODN 1826	Agonist	99.69%	Unkown
HY-146245C	ODN 1826 sodium	Agonist	99.51%	Unkown
HY-146244	Agatolimod	Agonist	98.84%	Unkown
HY-150741C	ODN 2216 sodium	Agonist	98.57%	Unkown
HY-150741	ODN 2216	Agonist	98.57%	Unkown
HY-N0201	Atractylenolide I	Antagonist	99.98%	Unkown
HY-150724	ODN 1018	Agonist	99.28%	Unkown
HY-150743	ODN 2395	Agonist	98.39%	Unkown
HY-150726C	ODN 1668 sodium	Agonist	98.79%	Unkown
HY-124603	AT791	Inhibitor	98.77%	Unkown
HY-150743C	ODN 2395 sodium	Agonist	98.20%	Unkown
HY-148045	TLR9-IN-1	Inhibitor	99.67%	Unkown
HY-12756	E6446	Antagonist	98.78%	Unkown
HY-150726	ODN 1668	Agonist	99.03%	Unkown
HY-12756A	E6446 dihydrochloride	Antagonist	99.29%	Unkown
HY-150750	ODN M362	Agonist	96.01%	Unkown
HY-150217A	CpG ODN 10101 sodium	Agonist	98.84%	Unkown
HY-150217	CpG ODN 10101	Agonist	99.44%	Unkown
HY-B1370R	Hydroxychloroquine sulfate (Standard)	Inhibitor	99.96%	Unkown
HY-101929	CU-CPT17e	Agonist	98.67%	Unkown
HY-150736	ODN 20844	Inhibitor	96.14%	Unkown
HY-146245F	FAM-labeled ODN 1826 sodium	Agonist	98.03%	Unkown
HY-114592	M199	Inhibitor	98.55%	Unkown
HY-150744	ODN 24888	Inhibitor	/	Unkown
HY-150745	ODN 24987	Inhibitor	/	Unkown
HY-150212	Tilsotolimod	Inhibitor	99.46%	Unkown
HY-178037	TLR9 antagonist 1	Antagonist	/	Unkown
HY-179474	TSI-13-57	Inhibitor	98.73%	Unkown
HY-150219A	ODN M326 sodium	Inhibitor	/	Unkown
HY-180507	TLR2/9 antagonist 1	Antagonist	/	Unkown
HY-179209	TLR9-IN-2	Inhibitor	/	Unkown
HY-178169	ETI60	Inhibitor	99.51%	Unkown
HY-150219	ODN M326	Agonist	/	Unkown
HY-183079	ENDO12	Inhibitor	/	Unkown
HY-183400	BIM-46174	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TLR9	MGD	MGI:1932389
Rattus norvegicus	TLR9	RGD	RGD:631352