2. Immunology/Inflammation
  3. Toll-like Receptor (TLR)
  4. ODN 1018 sodium

ODN 1018 sodium  (Synonyms: 1018 ISS sodium)

Cat. No.: HY-150724C Purity: 97.49%
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ODN 1018 (1018 ISS) sodium is a TLR9 agonist and immune modulator. ODN 1018 sodium exhibits adjuvant activity and augments CD8+ T cell responses with LNP-encapsulated OVA peptides. ODN 1018 sodium triggers sustained suppression of allergic airway inflammation. ODN 1018 sodium can be used for the research of allergic asthma and systemic lupus erythematosus.

For research use only. We do not sell to patients.

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Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of ODN 1018 sodium:

ODN 1018 sodium Related Antibodies

Top Publications Citing Use of Products
In Vivo Efficacy Study

    ODN 1018 sodium purchased from MedChemExpress. Usage Cited in: Nature. 2025 May;641(8061):202-210.  [Abstract]

    Mice were immunized with ABM5-OVA, or OVA peptide with or without 10 μg of ODN1018, ISCOMs or poly-I:C on days 0 and 14.

    ODN 1018 sodium purchased from MedChemExpress. Usage Cited in: Nature. 2025 May;641(8061):202-210.  [Abstract]

    Mice were immunized with ABM5-OVA, or OVA peptide with or without 10 μg of ODN1018, ISCOMs or poly-I:C on days 0 and 28.

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    Description

    ODN 1018 (1018 ISS) sodium is a TLR9 agonist and immune modulator. ODN 1018 sodium exhibits adjuvant activity and augments CD8+ T cell responses with LNP-encapsulated OVA peptides. ODN 1018 sodium triggers sustained suppression of allergic airway inflammation. ODN 1018 sodium can be used for the research of allergic asthma and systemic lupus erythematosus[1][2][3].

    IC50 & Target[1]

    TLR9

     

    In Vitro

    ODN1018 (0.7 μM) sodium stimulates proliferation and IL-6 production in purified human B cells, and this stimulation is inhibited by IRS at 0.35-0.7 μM[3].
    ODN1018 (0.7 μM; 48 h) sodium activates mouse splenocytes to produce IL-6 via TLR9, and this activation is dose-dependently inhibited by IRS 869 at 0.0875-0.7 μM[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    ODN 1018 sodium Related Antibodies
    In Vivo

    ODN1018 (10 μg per mouse; s.c.; days 0 and 14) sodium acts as an adjuvant to enhance OVA-specific CD8+ T cell responses by 7-fold in C57BL/6 mice[1].
    ODN 1018 (20 μg; intranasally; weekly; 1-17 weeks) sodium induces sustained suppression of allergic airway inflammation in ragweed-sensitized mice, with 5 weekly doses sufficient for durable effects associated with TReg induction[2].
    ODN 1018 (50 μg; s.c.) sodium induces a lethal TLR9-mediated inflammatory response in D-galactosamine-pretreated BALB/c mice[3].
    ODN 1018 (25 μg; s.c.) sodium stimulates TLR9-mediated cytokine (IL-6, IL-12) production in BALB/c mice[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: BALB/c (6-8 week old female, ragweed-sensitized allergic asthma model)[2]
    Dosage: 20 μg
    Administration: intranasally; weekly; 1, 3, 5, 8, 12, 13, 16, or 17 weeks
    Result: Suppressed bronchoalveolar lavage (BAL) eosinophilia, BAL IL-4, IL-5, IL-13 levels, and lung Th2-associated genes (Il13, Ccl11, Gob5, Fizz1) through 13 subsequent weekly ragweed exposures (12 weekly treatments).
    Induced significant, lasting reduction of Th2-mediated responses (5 weekly treatments); Upregulated lung regulatory T cell (TReg)-associated genes (Foxp3, Il10, Tgfb1, Lag3, Tnfrsf4, Il2ra) and increased TReg activity (CD4+CD25+ T cells from treated mice suppressed CD4+CD25- T cell proliferation more effectively than those from ragweed-only mice) (16 weekly treatments).
    Induced a moderate Th1 shift (progressive increase in lung Ifng, Cxcl9, Cxcl10 expression) but Th2 suppression did not require IFN-γ; Prevented ragweed-pulsed bone marrow dendritic cells from restoring Th2 responses.
    Clinical Trial
    Molecular Weight

    7150 (free acid)

    Appearance

    Solid

    Color

    Off-white to light yellow

    SMILES

    [ODN 1018 (sodium)]
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    -20°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Purity & Documentation

    Purity: 97.49%

    SDS (251 KB)

    COA (232 KB) LCMS (324 KB)

    Handling Instructions (2242 KB)
    References
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    ODN 1018 sodium Related Classifications

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    ODN 10181018 ISSODN1018ODN-1018Toll-like Receptor (TLR)immunostimulatoryvaccine adjuvantInhibitorinhibitorinhibit

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