2. Immunology/Inflammation
  3. Toll-like Receptor (TLR)
  4. ODN 2395 sodium

ODN 2395 sodium is a C class oligodeoxynucleotide and can be used as vaccine adjuvant. ODN 2395 sodium is also a TLR9 agonist. ODN 2395 sodium can be used in the research of immunological vaccines. Sequence: 5'-tcgtcgttttcggcgc:gcgccg-3'.

For research use only. We do not sell to patients.

DNA, d(P-thio)(T-C-G-T-C-G-T-T-T-T-C-G-G-C-G-C-G-C-G-C-C-G), sodium salt

ODN 2395 sodium Chemical Structure

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Based on 1 publication(s) in Google Scholar

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Description

ODN 2395 sodium is a C class oligodeoxynucleotide and can be used as vaccine adjuvant. ODN 2395 sodium is also a TLR9 agonist. ODN 2395 sodium can be used in the research of immunological vaccines. Sequence: 5'-tcgtcgttttcggcgc:gcgccg-3'[1][2].

IC50 & Target

TLR9

 

In Vivo

ODN 2395 (40 μg/per mouse; i.p.; 2 doses (5th and 6th weeks post-infection)) sodium increases serum HDL-C and IgG1 levels, and up-regulates liver TCR, ICOS, and Bax gene expression in normal nutritional status mice infected with Leishmania donovani, but does not reduce parasite loads or alter key immune cell or cytokine profiles[1].
ODN 2395 (40 μg/per mouse; i.p.; 2 doses (5th and 6th weeks post-infection)) sodium significantly reduces spleen parasite load, enhances Th1-type immune responses, increases serum HDL-C, and elevates IgG1 antibody levels in obesity mice infected with Leishmania donovani[1].
ODN 2395 (40 μg/per mouse; i.p.; 2 doses (5th and 6th weeks post-infection)) sodium significantly reduces spleen parasite load, up-regulates key spleen immune activation genes, reduces inhibitory cytokine levels, increases CD3+ T cell proportions, and down-regulates most measured liver immune and apoptosis-related genes in undernutrition mice infected with Leishmania donovani[1].
ODN 2395 (50 μg/mouse; i.n.; single dose; 1 day pre-infection) sodium confers 55% survival in HSV-1-infected BALB/c mice, significantly reduces brain viral load and pro-inflammatory cytokine production, and extends mean life expectancy to 17.4 days[2].
ODN 2395 (50 μg/mouse; i.n.; single dose; 3 days post-infection) sodium results in 0% survival in HSV-1-infected BALB/c mice, does not reduce whole-brain viral load, and increases viral load in the olfactory bulb at day 5 post-infection[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c (female, 6-8 weeks old, fed high-fat, high-sugar diets for 5 weeks to establish obesity then intraperitoneally inoculated with Leishmania donovani promastigotes)[1]
Dosage: 40 μg per mouse
Administration: I.p.; 2 doses (5th and 6th weeks post-infection)
Result: Caused a significant reduction in spleen parasite load.
Up-regulated spleen TCR, ICOS, and TLR4 gene expression.
Increased serum IFN-γ levels and the IFN-γ/IL-4 ratio.
Increased serum HDL-C levels.
Increased serum anti-Leishmania total IgG and IgG1 antibody levels.
Did not cause statistically significant changes to spleen T lymphocyte subsets proportions, liver parasite load, or serum anti-Leishmania IgG2a levels.
Molecular Weight

7035 (free acid)

Appearance

Solid

Color

White to off-white

SMILES

[DNA, d(P-thio)(T-C-G-T-C-G-T-T-T-T-C-G-G-C-G-C-G-C-G-C-C-G), sodium salt]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation

Purity: 98.20%

SDS (251 KB)

COA (239 KB) LCMS (303 KB)

Handling Instructions (2242 KB)
References
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ODN 2395 sodium Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ODN 2395ODN2395ODN-2395Toll-like Receptor (TLR)vaccine adjuvantInhibitorinhibitorinhibit

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