Cbl - Casitas B-lineage lymphoma Gene

Also Known as cbl; Cbl-2; c-Cbl; 4732447J05Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12402

Summary

Enables SH3 domain binding activity and Ephrin Receptor binding activity. Involved in regulation of platelet-derived growth factor receptor-alpha signaling pathway. Acts upstream of or within regulation of Rap protein signal transduction. Located in Golgi apparatus and cilium. Part of flotillin complex. Is expressed in male reproductive system and urinary system. Human ortholog(s) of this gene implicated in acute myeloid leukemia; juvenile myelomonocytic leukemia; lung non-small cell carcinoma; and myeloid neoplasm. Orthologous to human CBL (Cbl proto-oncogene). [provided by Alliance of Genome Resources, Apr 2022]

Cbl Products (1)

mRNA Protein Name
NM_007619.2 NP_031645.2 E3 ubiquitin-protein ligase CBL

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables SH3 domain binding IPI
IPI: Inferred from physical interaction
9447983 MGI
enables ephrin receptor binding IPI
IPI: Inferred from physical interaction
18034775 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
7657591 MGI
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
15383614 MGI
enables ubiquitin protein ligase activity IGI
IGI: Inferred from genetic interaction
11823423 MGI
enables ubiquitin protein ligase activity IMP
IMP: Inferred from mutant phenotype
12754251 MGI
Biological Process GO Annotation Evidence Références Source
involved in negative regulation of epidermal growth factor receptor signaling pathway IDA
IDA: Inferred from direct assay
23457600 MGI
involved in negative regulation of epidermal growth factor receptor signaling pathway IGI
IGI: Inferred from genetic interaction
11823423 MGI
involved in negative regulation of epidermal growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
12754251 MGI
involved in protein ubiquitination IDA
IDA: Inferred from direct assay
23457600 MGI
acts upstream of or within regulation of Rap protein signal transduction IMP
IMP: Inferred from mutant phenotype
12671687 MGI
involved in regulation of platelet-derived growth factor receptor-alpha signaling pathway IMP
IMP: Inferred from mutant phenotype
29237719 MGI
involved in ubiquitin-dependent endocytosis IMP
IMP: Inferred from mutant phenotype
15383614 MGI
involved in ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
23457600 MGI
Cellular Component GO Annotation Evidence Références Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
29237719 MGI
located in cilium IDA
IDA: Inferred from direct assay
29237719 MGI
part of flotillin complex IDA
IDA: Inferred from direct assay
11001060 MGI
is active in plasma membrane IDA
IDA: Inferred from direct assay
15383614 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase CBL

  • RING-type E3 ubiquitin transferase CBL

  • casitas B-lineage lymphoma proto-oncogene

  • proto-oncogene c-CBL

  • signal transduction protein CBL

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Nom du produit Effect
Pureté Rare Diseases
HY-B2209 Hydroxocobalamin 99.32% Yes

Clinical Phase

Bioactive Molecules (2)
Cat. No. Nom du produit Effect
Pureté Phase
HY-18935 CBL0137 99.73% Phase 2
HY-141432 NX-1607 Inhibitor 99.87% Phase 1

Pre-clinical Phase

Bioactive Molecules (42)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-18935A CBL0137 hydrochloride 99.72% Unkown
HY-136339 Cbl-b-IN-1 Inhibitor 99.66% Unkown
HY-155120 Cbl-b-IN-5 Inhibitor 99.05% Unkown
HY-P10412 A11 Inhibitor 98.49% Unkown
HY-W176629 Hydrocotarnine Inhibitor 99.70% Unkown
HY-156766 Cbl-b-IN-10 Inhibitor 98.85% Unkown
HY-155477 Cbl-b-IN-15 Inhibitor 99.78% Unkown
HY-156765 Cbl-b-IN-9 Inhibitor 98.55% Unkown
HY-161977 Cbl-b-IN-26 Inhibitor 99.81% Unkown
HY-156769 Cbl-b-IN-13 Inhibitor 98.46% Unkown
HY-141431 Cbl-b-IN-2 Inhibitor / Unkown
HY-156768 Cbl-b-IN-12 Inhibitor / Unkown
HY-E70079 Cystathionine β-lyase, Recombinant Microorganisms / Unkown
HY-156762 Cbl-b-IN-6 Inhibitor / Unkown
HY-156763 Cbl-b-IN-7 Inhibitor / Unkown
HY-156764 Cbl-b-IN-8 Inhibitor / Unkown
HY-156767 Cbl-b-IN-11 Inhibitor / Unkown
HY-158171 Cbl-b-IN-17 Inhibitor / Unkown
HY-158172 Cbl-b-IN-18 Inhibitor / Unkown
HY-158173 Cbl-b-IN-19 Inhibitor / Unkown
HY-158174 Cbl-b-IN-20 Inhibitor / Unkown
HY-159608 PROTAC Cbl-b-IN-1 Degrader / Unkown
HY-159615 Cbl-b-IN-21 Degrader / Unkown
HY-159617 Cbz-Pip-2C-Pip-C-Pip / Unkown
HY-159618 (3S)Lenalidomide-5-Pip-C-Pip-2C-Pip / Unkown
HY-163194 Cbl-b-IN-16 Inhibitor / Unkown
HY-164133 SM00465 Inhibitor / Unkown
HY-169005 Cbl-b-IN-27 Inhibitor / Unkown
HY-173311 Cbl-b-IN-28 / Unkown
HY-179575 Cbl-b-IN-29 / Unkown
HY-179617 Cbl-b-IN-30 Inhibitor / Unkown
HY-183293 Cbl-b-IN-32 Inhibitor / Unkown
HY-183997 Cbl-b-IN-33 / Unkown
HY-184236 Cbl-b-IN-34 Inhibitor / Unkown
HY-P10412A A11 acetate Inhibitor 98.48% Unkown
HY-P11479 Cbl-b-IN-31 Inhibitor / Unkown
HY-P11481 FITC-Acp-RpYTPEP-NH2 Ligand / Unkown
HY-RS01996 CBL Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W797329 (3S)Lenalidomide-5-Br 98.61% Unkown
HY-141432G NX-1607 (GMP) Inhibitor / Unkown
HY-RS17014 Cbl Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23457 Cbl Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cbl NCBI NCBI:867