ELAVL3 - ELAV like RNA binding protein 3 Gene

Also Known as HUC; HUCL; PLE21

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1995

About ELAVL3

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:11,451,326-11,481,046 (from NCBI)

This gene has 4 transcripts (splice variants), 184 orthologues and 24 paralogues. Restricted expression toward brain (RPKM 22.9).

Summary

A member of the ELAVL protein family, ELAV-like 3 is a neural-specific RNA-binding protein which contains three RNP-type RNA recognition motifs. The observation that ELAVL3 is one of several Hu antigens (neuronal-specific RNA-binding proteins) recognized by the anti-Hu serum antibody present in sera from patients with paraneoplastic encephalomyelitis and sensory neuronopathy (PEM/PSN) suggests it has a role in neurogenesis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

ELAVL3 Products (2)

mRNA	Protein	Name
NM_001420.4	NP_001411.2	ELAV-like protein 3 isoform 1
NM_032281.3	NP_115657.2	ELAV-like protein 3 isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Références	Source
enables mRNA 3'-UTR AU-rich region binding	IDA IDA: Inferred from direct assay	10710437	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	36950384	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ELAVL3 Protein Structure

RRM_1

0
100
200
300
367 a.a.

Protein Preferred Names	Protein Names
ELAV-like protein 3	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)

ELAVL3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	ELAVL3	Q14576	SYNGAP1	Homo sapiens	Q96PV0	Anti Bait CoIP	37207277

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ELAVL3 Proteins

Cat. No.	Nom du produit	Accession	Pureté
HY-P71819	ELAVL3 Protein, Human (P.pastoris, His)	Q14576 (M1-A367)	≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Sigmoid Disease	Sigmoid Diseases
Lambert-Eaton Myasthenic Syndrome	Lambert-Eaton Syndrome Eaton-Lambert Syndrome Lems Lambert Eaton Myasthenic Syndrome Eaton Lambert Syndrome Lambert Eaton Syndrome Myasthenic Syndrome Of Lambert-Eaton Myasthenic-Myopathic Syndrome Of Lambert-Eaton Lems - [Lambert-Eaton Myasthenic Syndrome]
Sensory Peripheral Neuropathy	Sensory Neuropathy Peripheral Sensory Neuropathy Hereditary Sensory And Autonomic Neuropathies
Limbic Encephalitis
Paraneoplastic Cerebellar Degeneration	Pcd Paraneoplastic Cerebellar Ataxia Rapidely Progressive Cerebellar Syndrome Subacute Cerebellar Degeneration
Bladder Carcinoma In Situ	Carcinoma In Situ Of Bladder Bladder Ca In Situ Flat Cis Of The Urinary Bladder Carcinoma In Situ Of Urinary Bladder
Radiation Cystitis	Irradiation Cystitis
Neurogenic Bowel
Hyperinsulinemic Hypoglycemia, Familial, 4	Hyperinsulinism Due To Glutamodehydrogenase Deficiency HHF4 Familial Hyperinsulinemic Hypoglycemia 4 Hyperinsulinemic Hypoglycemia Due To Short Chain 3-Hydroxylacyl-Coa Dehydrogenase Deficiency Hyperinsulinism Due To Schad Deficiency Hyperinsulinism Due To Short Chain 3-Hydroxylacyl-Coa Dehydrogenase Deficiency Congenital Hyperinsulinism Schad Deficiency Persistent Hyperinsulinemic Hypoglycemia Of Infancy Phhi 3-Hydroxyacyl-Coa Dehydrogenase Deficiency
Bladder Papillary Transitional Cell Neoplasm	Urinary Bladder Papillary Urothelial Neoplasm Bladder Papillary Urothelial Neoplasm
Urinary Tract Papillary Transitional Cell Benign Neoplasm	Inverted Papilloma Of Urinary Tract Papillary Transitional Cell Neoplasm Of The Urinary Tract Urinary Tract Inverted Papilloma Inverted Urothelial Papilloma
Intestinal Pseudo-Obstruction	Chronic Intestinal Pseudoobstruction Chronic Intestinal Pseudo-Obstruction Cipo Neuronal Intestinal Dysplasia Hollow Visceral Myopathy Familial Visceral Neuropathy Paralytic Ileus Intestinal Pseudoobstruction Chronic Idiopathic Intestinal Pseudo-Obstruction Ciip Congenital Short Bowel Syndrome Enteric Neuropathy Familial Visceral Myopathy Ipo Pseudo-Obstruction Of Intestine Pseudointestinal Obstruction Syndrome Pseudoobstructive Syndrome Congenital Idiopathic Intestinal Pseudoobstruction Visceral Myopathy, Familial
Myotonic Dystrophy 1	Myotonic Dystrophy Dystrophia Myotonica Steinert Disease Myotonic Dystrophy Type 1 Myotonia Atrophica DM1 Congenital Myotonic Dystrophy Myotonia Dystrophica Steinert Myotonic Dystrophy Dystrophia Myotonica 1 Dm Steinert'S Disease Steinert Myotonic Dystrophy Syndrome Myotonic Dystrophy Of Steinert Dystrophia Myotonica Type 1 Myotonic Dystrophy Congenital Dystrophy, Myotonic, Type 1 Dm - [Dystrophia Myotonica] Myotonic Muscular Dystrophy
Hirschsprung Disease 1	Hirschsprung Disease Aganglionic Megacolon Hscr Hirschsprung'S Disease Congenital Megacolon Congenital Intestinal Aganglionosis Colonic Aganglionosis Hirschsprung Disease, Susceptibility To, 1 Hirschsprung Disease, Protection Against HSCR1 Mgc Pelvirectal Achalasia Total Intestinal Aganglionosis Megacolon, Aganglionic Macrocolon Hscr 1 Hirschsprung Disease Type 1 Hirschsprung Disease, Type 1 Congenital Dilatation Of Colon Aganglionosis Congenital Aganglionic Megacolon Aganglionosis Of Colon Bowel Aganglionosis Colon Aganglionosis Hirschsprung Megacolon
Autosomal Dominant Cerebellar Ataxia	Spinocerebellar Ataxia Adca Pierre Marie Cerebellar Ataxia Ataxia, Spinocerebellar Sca Autosomal Dominant Spinocerebellar Ataxia Spinocerebellar Ataxias
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS04296	ELAVL3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20547	Elavl3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27056	Elavl3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ELAVL3	RGD	RGD:628892
Felis catus	ELAVL3	VGNC	VGNC:61803
Mus musculus	ELAVL3	MGD	MGI:109157
Macaca mulatta	ELAVL3	VGNC	VGNC:72202
Bos taurus	ELAVL3	VGNC	VGNC:28425
Canis familiaris	ELAVL3	VGNC	VGNC:40297
Others	ELAVL3	NCBI