HDAC8-IN-3
HDAC8-IN-3 (compound P19) is a potent HDAC8 inhibitor with IC50 value of 9.3 μM and produces thermal stabilization. HDAC8-IN-3 has cytotoxicity and induces apoptosis in leukemic cell lines.
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- CAS No.: 2432825-93-7
- Formule: C18H12N4O3S2
- Masse moléculaire:396.44
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
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HDAC8 9.3 μM (IC50) |
HDAC6 17 μM (IC50) |
HDAC2 41 μM (IC50) |
HDAC1 ＞50 μM (IC50) |
HDAC3 ＞50 μM (IC50) |
HDAC4 ＞50 μM (IC50) |
HDAC5 ＞50 μM (IC50) |
HDAC8 ＞50 μM (IC50) |
HDAC8-IN-3 (compound P19) (5-200 μM, 48 hours; HEK293T cells) has cytotoxicity in leukemic cell lines[1].
HDAC8-IN-3 (compound P19) (50 μM) inhibits glucose transporter 1 (GLUT1)-mediated glucose transport by down-regulating GLUT1 expression (IC50 = 28.2 μM)[1].
HDAC8-IN-3 (compound P19) (79.9 μM; 24 hours) can induce apoptotic death in the CEM cell line[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:K562, KCL22 and CEM leukemia cells.
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Concentration:50 μM
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Incubation Time:48 hours
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Result:Inhibited with IC50 values of 79.9, 85.4 and 43.2 μM for CEM, K562 and KCL22 cells, respectively.
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Cell Line:CEM cells
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Concentration:79.9 μM
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Incubation Time:24 hours
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Result:The percentage of apoptotic cells was recorded as 60.97%.
Chemical Information
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CAS No. 2432825-93-7
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Masse moléculaire 396.44
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Formule C18H12N4O3S2
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SMILES
O=C(NC1=NC2=CC=CC=C2S1)CN(C/3=O)C(SC3=C\C4=NC=CC=C4)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HDAC8-IN-3 Related Classifications
HY-147934 Related Classifications
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