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Cat. No.: HY-119103B

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PF-03246799 monohydrochloride

PF-03246799 monohydrochloride is a potent and selective 5-HT2C receptor agonist with an EC₅₀ of 190 nM and a K_i of 160 nM. PF-03246799 monohydrochloride shows selectivity for 5-HT2C over 5-HT2A and 5-HT2B receptors. PF-03246799 monohydrochloride has the potential for stress urinary incontinence (SUI) research.

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CAS No.: 1613666-08-2
Formule: C₁₅H₁₈ClN₃
Masse moléculaire:275.78

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

PF-03246799 monohydrochloride Chemical Structure

CAS No.: 1613666-08-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
Chemical Information
Pureté et documentation
Références
Calculators
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Activité biologique

Description

IC₅₀ & Target^[1]

5-HT_2C Receptor

190 nM (EC₅₀)

5-HT_2C Receptor

160 nM (Ki)

Voir tous les produits spécifiques à Isoform 5-HT Receptor :

Chemical Information

CAS No. 1613666-08-2
Masse moléculaire 275.78
Formule C₁₅H₁₈ClN₃
SMILES

C12=NC(CC3=CC=CC=C3)=NC=C1CCNCC2.Cl
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Andrews MD, et al. Pyrimido[4,5-d]azepines as potent and selective 5-HT2C receptor agonists: design, synthesis, and evaluation of PF-3246799 as a treatment for urinary incontinence. Bioorg Med Chem Lett. 2011 May 1;21(9):2715-20. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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PF-03246799 monohydrochloride

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PF-03246799 monohydrochloride

Voir tous les produits spécifiques à Isoform 5-HT Receptor

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

PF-03246799 monohydrochloride Related Classifications

HY-119103B Related Classifications