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Art. -Nr.: HY-173307

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Nrf2 activator 19

Nrf2 activator 19 is a BBB-penetrable NRF2/HO-1 activator. Nrf2 activator 19 exerts potent antioxidant and neuroprotective effects. Nrf2 activator 19 can also effectively reduce brain damage, reduce Reactive Oxygen Species (ROS) accumulation. Nrf2 activator 19 inhibits neuronal apoptosis. Nrf2 activator 19 promotes the recovery of neurological function and motor ability. Nrf2 activator 19 shows significant potential in ischemic stroke research.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₂₅H₂₀O₅
Molecular Weight:400.42

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

Nrf2 activator 19 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

Nrf2 activator 19 (Compound 6p) (40 μM, 24 h) shows no cytotoxicity in PC12 cells and RAW cells, the viability of PC12 cells under t-BHP injury could reach more than 90%, demonstrating a strong protective effect^[1].
Nrf2 activator 19 (2.5 μM-10 μM, 24 h) can effectively reduce ROS levels in PC12 cells, and shows a decrease in malondialdehyde (MDA) levels and an increase in superoxide dismutase (SOD) activity^[1].
Nrf2 activator 19 (2.5 μM-10 μM, 24 h) increases the expression of NRF2 and HO-1 proteins in a concentration-dependent manner in PC12 cells, indicating that it protects against oxidative damage by activating the NRF2 pathway.
Nrf2 activator 19 (10 μM, 3 h) reduces KEAP1 expression in PC12 cells, indicating a direct interaction with KEAP1^[1].
Nrf2 activator 19 (1 μM, 1 h) shows moderate metabolic stability in rat liver microsomes^[1].
Nrf2 activator 19 (10 μM, 24 h) shows a permeability of 7.64% in the Transwell-based blood-brain barrier (BBB) model (bEnd.3 cells), indicating its ability to cross the BBB^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

t-BHP (200 μM) treated PC12 cells
Concentration:

2.5 μM-20 μM
Incubation Time:

24 h
Result:

Demonstrated that it plays a protective role against oxidative damage by activating the NRF2 pathway, which not only reduced the levels of MDA and ROS, but also increased the expression of SOD and the antioxidant activity is as high as 95% at a concentration of 10 μM.

In Vivo

Nrf2 activator 19 (5-20 mg/kg, i.v. , 7 consecutive days) improves neurological recovery in a rat cerebral ischemia-reperfusion injury (MCAO) model and protects against ischemia-reperfusion injury by activating the NRF2 pathway^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

MCAO rat model^[1]
Dosage:

5-20 mg/kg
Administration:

i.v. , 7 consecutive days
Result:

Reduced the infarct area of rats, indicating that it has a protective effect on the nerve damage caused by cerebral ischemia-reperfusion.
Enhanced the expression of NRF2 and HO-1 proteins in the nucleus of rat cerebral ischemia-reperfusion injury (MCAO) model in a concentration-dependent manner, and counteract ischemia-reperfusion injury by activating the NRF2 pathway.
In the Barnes maze experiment, rats were able to find the target box quickly, indicating that it can effectively restore the nerve function of rats.

Chemical Information

Molecular Weight 400.42
Formel C₂₅H₂₀O₅
SMILES

OC1=CC=C(C(/C=C/C2=C3C(OC(C4=CC=C(C)C=C4)=C3)=C(OC)C=C2)=O)C=C1O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Su W, et al. Design, synthesis and biological evaluation of 2-arylbenzo[b]furan-4-vinylcarbonyl derivatives based on Salvianolic acid C as antioxidant neuroprotective agents for the treatment of ischemic stroke. Eur J Med Chem. 2025 Mar 13;290:117506. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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