Adenosine-13C5
Based on 1 Customer Validation
Adenosine-13C5 is the 13C labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation.
For research use only. We do not sell to patients.
- Purity: 99.9%
- CAS No.: 159496-13-6
- Formula: C513C5H13N5O4
- Molecular Weight:272.20
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 159496-13-6
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Unlabeled Cas 58-61-7
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Appearance Solid
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Molecular Weight 272.20
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Formula C513C5H13N5O4
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Color White to off-white
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SMILES
NC1=C(N=CN2[13C@H]3[13C@H](O)[13C@H](O)[13C@@H]([13CH2]O)O3)C2=NC=N1
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Synonyms
Adenine riboside-13C5; D-Adenosine-13C5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 33.33 mg/mL (122.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : ≥ 6.67 mg/mL (24.50 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (279 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[2]. Borea PA, Gessi S, Merighi S, Vincenzi F, Varani K. Pharmacology of Adenosine Receptors: The State of the Art. Physiol Rev. 2018;98(3):1591-1625. [Content Brief]
[3]. Fredholm BB. Adenosine, an endogenous distress signal, modulates tissue damage and repair. Cell Death Differ. 200714(7):1315-1323. [Content Brief]
[4]. Zhou XT, et al. Inhibition of autophagy enhances adenosine induced apoptosis in human hepatoblastoma HepG2 cells. Oncol Rep. 201941(2):829-838. [Content Brief]
[5]. Eltzschig HK. Adenosine: an old drug newly discovered. Anesthesiology. 2009111(4):904-915. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 3.6738 mL | 18.3688 mL | 36.7377 mL | 91.8442 mL |
| 5 mM | 0.7348 mL | 3.6738 mL | 7.3475 mL | 18.3688 mL | |
| 10 mM | 0.3674 mL | 1.8369 mL | 3.6738 mL | 9.1844 mL | |
| 15 mM | 0.2449 mL | 1.2246 mL | 2.4492 mL | 6.1229 mL | |
| 20 mM | 0.1837 mL | 0.9184 mL | 1.8369 mL | 4.5922 mL | |
| DMSO | 25 mM | 0.1470 mL | 0.7348 mL | 1.4695 mL | 3.6738 mL |
| 30 mM | 0.1225 mL | 0.6123 mL | 1.2246 mL | 3.0615 mL | |
| 40 mM | 0.0918 mL | 0.4592 mL | 0.9184 mL | 2.2961 mL | |
| 50 mM | 0.0735 mL | 0.3674 mL | 0.7348 mL | 1.8369 mL | |
| 60 mM | 0.0612 mL | 0.3061 mL | 0.6123 mL | 1.5307 mL | |
| 80 mM | 0.0459 mL | 0.2296 mL | 0.4592 mL | 1.1481 mL | |
| 100 mM | 0.0367 mL | 0.1837 mL | 0.3674 mL | 0.9184 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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