Estradiol enanthate
Based on 1 Customer Validation
Estradiol enanthate (E2EN) is a shorter-acting estrogen. Estradiol enanthate is an injectable contraceptive in combination with Dihydroxyprogesterone acetophenide. Estradiol enanthate promotes withdrawal bleeding, in a pattern similar to menstruation.
For research use only. We do not sell to patients.
- Purity: 98.07%
- CAS No.: 4956-37-0
- Formula: C25H36O3
- Molecular Weight:384.55
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Endocrinology Compound Library
HY-L047
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Protein-protein Interaction Inhibitor Library
HY-L109
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Human Metabolite Library
HY-L123
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Nuclear Receptor Compound Library
HY-L126
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Membrane Receptor-targeted Compound Library
HY-L150
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
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Human Hormone Compound Library
HY-L211
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Mass Spectrometry Human Metabolite Library
HY-L215
Biological Activity
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Two-month old male and female Wistar rats[2]
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Dosage:10 mg, every 10 days for 5 months, in combination with 150 mg of Dihydroxyprogesterone acetophenide
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Administration:Intramuscular injection (i.m.)
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Result:Reduced body weight of male rats and was similar to female rats.
Diminished both hematocrit and hemoglobin in male rats.
Did not alter hepatic enzyme AST and ALT range.
Markedly increase the daily food and water intake.
Did not alter systolic blood pressure and glomerular filtration rate in male rats after 5 months.
Reduced proteinuria in all male rats compared to female rats.
Increased plasma urea and creatinine concentration compared to control group.
Chemical Information
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CAS No. 4956-37-0
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Appearance Solid
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Molecular Weight 384.55
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Formula C25H36O3
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Color White to off-white
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SMILES
C[C@@]12[C@@H](OC(CCCCCC)=O)CC[C@@]1([H])[C@]3([H])CCC4=C(C=CC(O)=C4)[C@@]3([H])CC2
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Synonyms
E2EN
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : 125 mg/mL (325.06 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Ethanol : ≥ 100 mg/mL (260.04 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% EtOH 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (6.50 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (272 KB)
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SDS (418 KB)
- English - EN (418 KB)
- Français - FR (418 KB)
- Deutsch - DE (418 KB)
- Norwegian - NO (418 KB)
- Español - ES (418 KB)
- Swedish - SV (418 KB)
- Italian - IT (418 KB)
- Korean - KR (418 KB)
- Portuguese - PT (418 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Ethanol / DMSO | 1 mM | 2.6004 mL | 13.0022 mL | 26.0044 mL | 65.0111 mL |
| 5 mM | 0.5201 mL | 2.6004 mL | 5.2009 mL | 13.0022 mL | |
| 10 mM | 0.2600 mL | 1.3002 mL | 2.6004 mL | 6.5011 mL | |
| 15 mM | 0.1734 mL | 0.8668 mL | 1.7336 mL | 4.3341 mL | |
| 20 mM | 0.1300 mL | 0.6501 mL | 1.3002 mL | 3.2506 mL | |
| 25 mM | 0.1040 mL | 0.5201 mL | 1.0402 mL | 2.6004 mL | |
| 30 mM | 0.0867 mL | 0.4334 mL | 0.8668 mL | 2.1670 mL | |
| 40 mM | 0.0650 mL | 0.3251 mL | 0.6501 mL | 1.6253 mL | |
| 50 mM | 0.0520 mL | 0.2600 mL | 0.5201 mL | 1.3002 mL | |
| 60 mM | 0.0433 mL | 0.2167 mL | 0.4334 mL | 1.0835 mL | |
| 80 mM | 0.0325 mL | 0.1625 mL | 0.3251 mL | 0.8126 mL | |
| 100 mM | 0.0260 mL | 0.1300 mL | 0.2600 mL | 0.6501 mL |
Estradiol enanthate Related Classifications
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