Nr1h4 - nuclear receptor subfamily 1, group H, member 4 Gene

Also Known as Fxr; HRR1; RIP14; Rxrip14

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20186

About Nr1h4

Chromosome 10: 89,290,096-89,369,447 reverse strand.GRCm39:CM001003.3

This gene has 3 transcripts (splice variants), 388 orthologues, 19 paralogues and is associated with 65 phenotypes. Biased expression in large intestine adult (RPKM 22.6), liver adult (RPKM 18.8) and 1 other tissues.

Summary

Enables DNA-binding transcription factor activity, RNA polymerase II-specific; bile acid binding activity; and retinoid X receptor binding activity. Involved in several processes, including lipid homeostasis; negative regulation of cytokine production; and regulation of signal transduction. Acts upstream of or within several processes, including Notch signaling pathway; bile acid metabolic process; and negative regulation of very-low-density lipoprotein particle remodeling. Predicted to be located in euchromatin and nucleus. Predicted to be part of receptor complex. Is expressed in several structures, including 1st branchial arch; central nervous system; liver; sensory organ; and urinary system. Used to study hepatocellular carcinoma. Human ortholog(s) of this gene implicated in extrahepatic cholestasis; hepatocellular carcinoma; and progressive familial intrahepatic cholestasis 5. Orthologous to human NR1H4 (nuclear receptor subfamily 1 group H member 4). [provided by Alliance of Genome Resources, Apr 2022]

Nr1h4 Products (4)

mRNA Protein Name
NM_001385711.1 NP_001372640.1 bile acid receptor isoform 4
NM_001163700.1 NP_001157172.1 bile acid receptor isoform 1
NM_001163504.1 NP_001156976.1 bile acid receptor isoform 2
NM_009108.2 NP_033134.2 bile acid receptor isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
27471003 MGI
enables DNA-binding transcription factor activity IGI
IGI: Inferred from genetic interaction
7760852 MGI
enables bile acid binding IMP
IMP: Inferred from mutant phenotype
21757002 MGI
enables bile acid nuclear receptor activity IMP
IMP: Inferred from mutant phenotype
21757002 MGI
enables nuclear receptor activity IDA
IDA: Inferred from direct assay
27471003 MGI
enables nuclear retinoid X receptor binding IDA
IDA: Inferred from direct assay
7760852 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
14729567 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within Notch signaling pathway IDA
IDA: Inferred from direct assay
25446530 MGI
acts upstream of or within bile acid metabolic process IMP
IMP: Inferred from mutant phenotype
12917447 MGI
involved in cell-cell junction assembly IMP
IMP: Inferred from mutant phenotype
16473946 MGI
involved in cellular response to bile acid IMP
IMP: Inferred from mutant phenotype
21757002 MGI
involved in cellular response to lipopolysaccharide IMP
IMP: Inferred from mutant phenotype
18972444 MGI
involved in cholesterol homeostasis IMP
IMP: Inferred from mutant phenotype
12421815 MGI
involved in defense response to bacterium IDA
IDA: Inferred from direct assay
16473946 MGI
involved in fatty acid homeostasis IMP
IMP: Inferred from mutant phenotype
16557297 MGI
involved in glucose homeostasis IDA
IDA: Inferred from direct assay
14729567 MGI
involved in intracellular glucose homeostasis IDA
IDA: Inferred from direct assay
16446356 MGI
involved in negative regulation of NF-kappaB transcription factor activity IMP
IMP: Inferred from mutant phenotype
18972444 MGI
involved in negative regulation of canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
18972444 MGI
involved in negative regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
18972444 MGI
involved in negative regulation of interleukin-1 production IMP
IMP: Inferred from mutant phenotype
18972444 MGI
involved in negative regulation of interleukin-2 production IMP
IMP: Inferred from mutant phenotype
18972444 MGI
involved in negative regulation of interleukin-6 production IDA
IDA: Inferred from direct assay
21242261 MGI
involved in negative regulation of monocyte chemotactic protein-1 production IMP
IMP: Inferred from mutant phenotype
18972444 MGI
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
21757002 MGI
involved in negative regulation of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
18972444 MGI
involved in negative regulation of tumor necrosis factor-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
18972444 MGI
involved in negative regulation of type II interferon production IMP
IMP: Inferred from mutant phenotype
18972444 MGI
acts upstream of or within negative regulation of very-low-density lipoprotein particle remodeling IDA
IDA: Inferred from direct assay
27471003 MGI
involved in nuclear receptor-mediated bile acid signaling pathway IMP
IMP: Inferred from mutant phenotype
21757002 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
27471003 MGI
involved in positive regulation of adipose tissue development IMP
IMP: Inferred from mutant phenotype
16446356 MGI
involved in positive regulation of ammonia assimilation cycle IMP
IMP: Inferred from mutant phenotype
21757002 MGI
involved in positive regulation of glutamate metabolic process IMP
IMP: Inferred from mutant phenotype
21757002 MGI
involved in positive regulation of insulin receptor signaling pathway IDA
IDA: Inferred from direct assay
16446356 MGI
involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus IMP
IMP: Inferred from mutant phenotype
20447400 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
24211198 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
21757002 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
7760852 MGI
involved in regulation of urea metabolic process IMP
IMP: Inferred from mutant phenotype
21757002 MGI
involved in toll-like receptor 9 signaling pathway IMP
IMP: Inferred from mutant phenotype
23372731 MGI
acts upstream of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
24211198 MGI
involved in triglyceride homeostasis IDA
IDA: Inferred from direct assay
12891557 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Nr1h4 Protein Structure

NR_DBD_FXR

NR_DBD_FXR: cd06962 (134 - 217)

NR_LBD_Fxr

NR_LBD_Fxr: cd06936 (259 - 478)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 484 a.a.
Protein Preferred Names Protein Names

bile acid receptor

  • RXR-interacting protein 14

  • farnesoid X activated receptor

  • farnesol receptor HRR-1

  • retinoid X receptor-interacting protein 14

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-125996 NR1H4 activator 1 Agonist / Unkown
HY-RS09531 NR1H4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09532 Nr1h4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09533 Nr1h4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-182395 DM175 Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nr1h4 NCBI NCBI:9971