CPEB4 - cytoplasmic polyadenylation element binding protein 4 Gene

Also Known as CPE-BP4; hCPEB-4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 80315

About CPEB4

Cytogenetic location: 5q35.2 Genomic coordinates (GRCh38): 5:173,888,349-173,961,980 (from NCBI)

This gene has 13 transcripts (splice variants), 285 orthologues and 3 paralogues. Ubiquitous expression in adrenal (RPKM 26.5), bone marrow (RPKM 18.8) and 25 other tissues.

Summary

Enables RNA binding activity. Predicted to be involved in several processes, including cellular response to glucose starvation; negative regulation of cytoplasmic translation; and response to ischemia. Located in cytoplasm and nucleus. Biomarker of liver cirrhosis; portal hypertension; and primary biliary cholangitis. [provided by Alliance of Genome Resources, Apr 2022]

CPEB4 Products (5)

mRNA Protein Name
NM_001308189.2 NP_001295118.1 cytoplasmic polyadenylation element-binding protein 4 isoform b
NM_001308191.2 NP_001295120.1 cytoplasmic polyadenylation element-binding protein 4 isoform c
NM_001308192.2 NP_001295121.1 cytoplasmic polyadenylation element-binding protein 4 isoform d
NM_001308193.2 NP_001295122.1 cytoplasmic polyadenylation element-binding protein 4 isoform e
NM_030627.4 NP_085130.2 cytoplasmic polyadenylation element-binding protein 4 isoform a

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21336257 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
20639532 GOA
located in nucleus IDA
IDA: Inferred from direct assay
20639532 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CPEB4 Protein Structure

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (474 - 535)

  • 0
  • 200
  • 400
  • 600
  • 729 a.a.
Protein Preferred Names Protein Names

cytoplasmic polyadenylation element-binding protein 4

  • CPE-binding protein 4

CPEB4 Antibodies

Cat. No. Product Name Application Reactivity
HY-P811349 CPEB4 Antibody WB, IHC-P Human, Mouse

Related Diseases

Diseases Alias
Portal Hypertension

  • Hypertension, Portal

  • Hypertension Portal

  • Pht - [Portal Hypertension]

  • Portal Htn
Primary Biliary Cholangitis

  • Primary Biliary Cirrhosis

  • Biliary Liver Cirrhosis

  • Chronic Nonsuppurative Destructive Cholangitis

  • Familial Primary Biliary Cirrhosis

  • Pbc

  • Hanot Syndrome

  • Cholestatic Cirrhosis

  • Biliary Cirrhosis Primary

  • Liver Cirrhosis, Biliary

  • Hanot'S Cirrhosis

  • Biliary Cirrhosis

  • Pericholangiolic Biliary Cirrhosis

  • Tannhauser-Magendantz Syndrome

  • Hanot-Rossle Syndrome

  • Hypertrophic Cirrhosis

  • Todd Cirrhosis

  • Hanot Cirrhosis

  • Charcot Cirrhosis

  • Mahon-Tannhauser Syndrome

  • Toxic Cirrhosis

  • Hypertrophic Biliary Cirrhosis

  • Monolobular Cirrhosis

  • Unilobar Cirrhosis

  • Xanthomatous Biliary Cirrhosis
Autism

  • Autistic Disorder

  • Autism Susceptibility 1

  • Childhood Autism

  • Autistic Disorder Of Childhood Onset

  • Infantile Autism

  • Kanner'S Syndrome

  • Autistic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P10778 me4 Peptide / Unkown
HY-RS03094 CPEB4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20386 Cpeb4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26896 Cpeb4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CPEB4 VGNC VGNC:39554
Mus musculus CPEB4 MGD MGI:1914829
Bos taurus CPEB4 VGNC VGNC:27650
Felis catus CPEB4 VGNC VGNC:61121
Macaca mulatta CPEB4 VGNC VGNC:71450
Rattus norvegicus CPEB4 RGD RGD:1311931
Others CPEB4 NCBI