Venturicidin A
Based on 1 Customer Validation
Venturicidin A (Aabomycin A1), from actinomycetes, is a membrane-active natural product inhibitor of ATP synthase. Venturicidin A potentiates the aminoglycoside antibiotic gentamicin against multidrug-resistant clinical isolates of Staphylococcus, Enterococcus, and Pseudomonas aeruginosa. Venturicidin A shows noticeable toxicity toward human embryonic-kidney (HEK)cells with an IC50 of 31 μg/mL.
For research use only. We do not sell to patients.
- Purity: 96.60%
- CAS No.: 33538-71-5
- Formula: C41H67NO11
- Molecular Weight:749.97
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Antibiotic Isoforms
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Biological Activity
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Aminoglycoside |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| B16 | IC50 |
12 μM
Compound: 4
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Cytotoxicity against mouse B16 cells assessed as inhibition of cell growth measured after 72 hrs by Celltiter-Glo assay
Cytotoxicity against mouse B16 cells assessed as inhibition of cell growth measured after 72 hrs by Celltiter-Glo assay
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[PMID: 33356258] |
| Hep 3B2 | IC50 |
15 μM
Compound: 4
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Cytotoxicity against human Hep3B cells assessed as inhibition of cell growth measured after 72 hrs by Celltiter-Glo assay
Cytotoxicity against human Hep3B cells assessed as inhibition of cell growth measured after 72 hrs by Celltiter-Glo assay
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[PMID: 33356258] |
| K562 | IC50 |
5.8 μM
Compound: 4
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Cytotoxicity against human K562 cells assessed as inhibition of cell growth measured after 72 hrs by Celltiter-Glo assay
Cytotoxicity against human K562 cells assessed as inhibition of cell growth measured after 72 hrs by Celltiter-Glo assay
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[PMID: 33356258] |
| MDA-MB-468 | IC50 |
8.3 μM
Compound: 4
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Cytotoxicity against human MDA-MB-468 cells assessed as inhibition of cell growth measured after 72 hrs by Celltiter-Glo assay
Cytotoxicity against human MDA-MB-468 cells assessed as inhibition of cell growth measured after 72 hrs by Celltiter-Glo assay
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[PMID: 33356258] |
| MV4-11 | IC50 |
0.09 μM
Compound: 4
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Cytotoxicity against human MV4-11 cells assessed as inhibition of cell growth measured after 72 hrs by Celltiter-Glo assay
Cytotoxicity against human MV4-11 cells assessed as inhibition of cell growth measured after 72 hrs by Celltiter-Glo assay
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[PMID: 33356258] |
Chemical Information
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CAS No. 33538-71-5
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Appearance Solid
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Molecular Weight 749.97
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Formula C41H67NO11
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Color White to off-white
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SMILES
CC1=CC[C@](O)(C2)O[C@]1([H])/C(C)=C\CCC[C@](O[C@@]3([H])C[C@H]([C@H](O)[C@@H](C)O3)OC(N)=O)([H])/C=C/[C@H](C)C[C@@H](C)[C@]([C@H](C)C[C@@H](C)[C@H](O)[C@H](C)C(CC)=O)([H])OC2=O
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Synonyms
Aabomycin A1
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Structure Classification
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Initial Source
actinomycetes
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 8 mg/mL (10.67 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.3334 mL | 6.6669 mL | 13.3339 mL | 33.3347 mL |
| 5 mM | 0.2667 mL | 1.3334 mL | 2.6668 mL | 6.6669 mL | |
| 10 mM | 0.1333 mL | 0.6667 mL | 1.3334 mL | 3.3335 mL |
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