33538-71-5
Chemical Structure
Venturicidin A
Synonym(s): Aabomycin A1
- CAS No.: 33538-71-5
- Formula:C41H67NO11
- Molecular Weight:749.97
IUPAC Name: (2R,3R,4R,6R)-3-hydroxy-6-(((1R,5S,6R,8R,9E,11R,15Z,17R)-1-hydroxy-5-((2R,4R,5S,6S)-5-hydroxy-4,6-dimethyl-7-oxononan-2-yl)-6,8,16,18-tetramethyl-3-oxo-4,21-dioxabicyclo[15.3.1]henicosa-9,15,18-trien-11-yl)oxy)-2-methyltetrahydro-2H-pyran-4-yl carbamate
InChIKey: HHQKNFDAEDTRJK-KXQVSFSQSA-N
SMILES: CC1=CC[C@](O)(C2)O[C@]1([H])/C(C)=C\CCC[C@](O[C@@]3([H])C[C@H]([C@H](O)[C@@H](C)O3)OC(N)=O)([H])/C=C/[C@H](C)C[C@@H](C)[C@]([C@H](C)C[C@@H](C)[C@H](O)[C@H](C)C(CC)=O)([H])OC2=O
Biological Activity: Venturicidin A (Aabomycin A1) is a natural product derived from Streptomyces, possessing antifungal, anti-Trypanosoma brucei, anti-Leishmania donovani, and ATP synthase inhibitory activities. Venturicidin A acts as an antibiotic adjuvant, promoting the uptake of aminoglycoside antibiotics and enhancing bactericidal efficacy. Venturicidin A inhibits ATP synthesis by blocking proton translocation through the FO subunit. In bloodstream-form Trypanosoma brucei, Venturicidin A causes collapse of the mitochondrial membrane potential; in fungi, it disrupts cell membrane integrity, induces leakage of cytoplasmic contents, elevates ROS levels, and downregulates the expression of fungal pathogenicity-related genes. Venturicidin A exhibits antifungal activity against Botrytis cinerea. Venturicidin A is used in research on bacterial infections, trypanosome/leishmania infections, and gray mold disease[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Venturicidin A | 96.6% | Venturicidin A (Aabomycin A1) is a natural product derived from Streptomyces, possessing antifungal, anti-Trypanosoma brucei, anti-Leishmania donovani, and ATP synthase inhibitory activities. Venturicidin A acts as an antibiotic adjuvant, promoting the uptake of aminoglycoside antibiotics and enhancing bactericidal efficacy. Venturicidin A inhibits ATP synthesis by blocking proton translocation through the FO subunit. In bloodstream-form Trypanosoma brucei, Venturicidin A causes collapse of the mitochondrial membrane potential; in fungi, it disrupts cell membrane integrity, induces leakage of cytoplasmic contents, elevates ROS levels, and downregulates the expression of fungal pathogenicity-related genes. Venturicidin A exhibits antifungal activity against Botrytis cinerea. Venturicidin A is used in research on bacterial infections, trypanosome/leishmania infections, and gray mold disease. | ||||||||||||||||||||
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References
- [1]. Yarlagadda V, et al. Venturicidin A, A Membrane-active Natural Product Inhibitor of ATP synthase Potentiates Aminoglycoside Antibiotics. Scientific reports. 2020 May 18;10(1):8134. [Content Brief]
- [2]. Hu L, et al. Antifungal activity mechanisms of venturicidin A against Botrytis cinerea contributes to the control of gray mould. Pest management science. 2025 Feb;81(2):1113-1126.
- [3]. Hauser DA, et al. Venturicidin A affects the mitochondrial membrane potential and induces kDNA loss in Trypanosoma brucei. Antimicrob Agents Chemother. 2024 Jul 9;68(7):e0167123.
