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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
128 Results for "
epoetin-zeta
" in MedChemExpress (MCE) Product Catalog:
Products (128)
128 Results for "epoetin-zeta" in MCE Product Catalog:
82
82 Publications Verification
Synonyms: Gö 6983; Goe 6983
Go 6983 is a pan-PKC inhibitor against for PKCα, PKCβ, PKCγ, PKCδ and PKCζ with IC50 of 7 nM, 7 nM, 6 nM, 10 nM and 60 nM, respectively.
22
22 Cited Publications
Synonyms: Mallotoxin; NSC 56346; NSC 94525
4
4 Cited Publications
Target:
Research Areas:
JH-RE-06, a potent REV1-REV7 interface inhibitor (IC50=0.78 μM; Kd=0.42 μM), targets REV1 that interacts with the REV7 subunit of POLζ. JH-RE-06 disrupts mutagenic translesion synthesis (TLS) by preventing recruitment of mutagenic POLζ. JH-RE-06 improves chemotherapy .
3
BAY 2965501 is a potent and selective diacylglycerol kinase zeta (DGKζ) inhibitor. BAY 2965501 induces pERK activation. BAY 2965501 can be used for the research of cancer .
3
3 Cited Publications
Target:
Research Areas:
ZAP-180013 is a zeta-chain-associated protein kinase 70 (ZAP-70) inhibitor with an IC50 of 1.8 μM. ZAP-180013 inhibits the interaction of ZAP-70 SH2 domain with immunoreceptor tyrosine-based activation motif (ITAMs) .
3
ζ-Stat (NSC37044) is a specific and atypical PKC-ζ inhibitor, with an IC50 of 5 μM. ζ-Stat can reduce melanoma cell lines proliferation and induce apoptosis, and has antitumor activity in vitro .
3
3 Cited Publications
Synonyms: NSC37044 trisodium
ζ-Stat trisodium (NSC37044 trisodium) is a specific and atypical PKC-ζ inhibitor, with an IC50 of 5 μM. ζ-Stat trisodium can reduce melanoma cell lines proliferation and induce apoptosis, and has antitumor activity in vitro .
2
2 Cited Publications
Cat. No.: HY-P1284
CAS No.: 863987-12-6
Target:
Research Areas:
2
2
2 Cited Publications
Cat. No.: HY-P70455
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Interleukin-37; FIL1 zeta; IL-1X; Interleukin-1 Family Member 7; IL-1F7; Interleukin-1 Homolog 4; IL-1H; IL-1H4; Interleukin-1 zeta; IL-1 zeta; Interleukin-1-Related Protein; IL-1RP1; Interleukin-23; IL-37; IL37; FIL1Z; IL1F7; IL1H4; IL1RP1
2
2 Cited Publications
1
1 Cited Publications
Target:
Research Areas:
BMS-502 (Compound 22) is a potent dual inhibitor of diacylglycerol kinase (DGK) α and ζ with IC50 of 4.6 nM and 2.1 nM. BMS-502 enhanced T cell immune responses in mice. BMS-502 can be used in tumor immunity related research .
1
1 Cited Publications
Cat. No.: HY-P86804
Synonyms: 4930549J05Rik antibody;
A430104F18Rik antibody;
AW552088 antibody;
Cd247 antibody;
CD3 antibody;
CD3 delta antibody;
CD3 epsilon antibody;
CD3 eta antibody;
CD3 gamma antibody;
CD3 zeta antibody;
CD3H antibody;
CD3Q antibody;
CD3Z antibody;
CD3zeta antibody;
Ctg3 antibody;
FLJ17620 antibody;
FLJ17664 antibody;
FLJ18683 antibody;
FLJ79544 antibody
FLJ94613 antibody;
IMD19 antibody;
Leu-4 antibody;
MGC138597 antibody;
OKT3, delta chain antibody;
OTTHUMP00000032544 antibody;
T cell receptor antibody;
T3 antibody;
T3d antibody;
T3e antibody;
T3g antibody;
T3z antibody;
TCRE antibody;
TCRk antibody;
Tcrz antibody;
TCRzeta antibody
Cat. No.: HY-159649
CAS No.: 2618418-12-3
Target:
Research Areas:
BMS-986408 is an orally active inhibitor of DGKα and DGKζ, with IC50 values of 0.0003 μM and 0.002 μM, respectively. BMS-986408 activates intratumoral T cell responses, enhances the priming and expansion of tumor-reactive T cells in tumor-draining lymph nodes, and functions as an immunostimulant. BMS-986408 can be used in the research of tumors .
Cat. No.: HY-115501
CAS No.: 1370281-06-3
Target:
Research Areas:
(E)-FOBISIN101 is a 14-3-3 protein-protein interaction (14-3-3 protein-protein interaction) inhibitor, with IC50 values of 9.3 and 16.4 μM for disrupting the binding of 14-3-3ζ or 14-3-3γ to PRAS40, respectively. (E)-FOBISIN101 inhibits the binding of 14-3-3 to Raf-1 and proline-rich AKT substrate, and neutralizes the ability of 14-3-3 to activate exotoxin S ADP-ribosyltransferase. (E)-FOBISIN101 is applicable to 14-3-3-mediated cancer research .
Synonyms: rhEPO; EPOCH; Genetical recombination
Target:
Research Areas:
Target:
Research Areas:
Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
WS3 is an allosteric inhibitor of 14-3-3 (14-3-3ζ: Kd = 2.29 μM). WS3 activates GSK3β by disrupting the binding of 14-3-3-pGSK3β, promotes the ubiquitination and degradation of NRF2, and inhibits the NRF2-ARE signaling pathway (IC50 = 135 nM). It exerts antioxidant inhibition and chemotherapeutic/ferroptosis sensitizing effects in tumors with hyperactivated NRF2. WS3 binds to EBP1/IKKε and promotes the proliferation of β cells and retinal pigment epithelial (RPE) cells, which can be applied to islet regeneration and RPE expansion transplantation . WS3 is applicable to research related to age-related macular degeneration, retinal degeneration and non-small cell lung cancer .
Cat. No.: HY-153793
CAS No.: 2660218-70-0
Synonyms: DGKζ-IN-1
Target:
Research Areas:
Alcudacigib (ASP1570; DGKζ-IN-1) is an orally active diacylglycerol kinase ζ (DGKζ) inhibitor, with an IC50 of 4.7 nM against human DGKζ and an IC50 of 3.0 nM against mouse DGKζ. Alcudacigib selectively inhibits the kinase activity of DGKζ and induces proteasome-dependent degradation of DGKζ protein. Alcudacigib enhances the anti-tumor functions of T cells and NK cells. Alcudacigib can be used for the research of advanced/metastatic solid tumors .
Cat. No.: HY-18713
CAS No.: 1438881-19-6
Research Areas:
CRT0066854 is a potent and selective atypical PKC isoenzymes inhibitor. CRT0066854 is against full-length (FL) PKCι, PKCζ, and ROCK-II kinases with IC50 values of 132 nM, 639 nM, and 620 nM, respectively .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
