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Epoetin beta (Synonyms: rhEPO; EPOCH; Genetical recombination)

Cat. No.: HY-114134
Handling Instructions

Epoetin beta (rhEPO) is a recombinant form of erythropoietin. Epoetin beta is responsible for the maintenance of erythropoiesis and can be used for anaemia research.

For research use only. We do not sell to patients.

Epoetin beta Chemical Structure

Epoetin beta Chemical Structure

CAS No. : 122312-54-3

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Description

Epoetin beta (rhEPO) is a recombinant form of erythropoietin. Epoetin beta is responsible for the maintenance of erythropoiesis and can be used for anaemia research[1].

In Vivo

Epoetin beta (rhEPO) (1000 IU/kg; s.c.; three times per week over 14 days) prevents anaemia and enhances the radiosensitivity of solid growing DS-sarcomas[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats, body weight 140-170 g[2]
Dosage: 1000 IU/kg
Administration: Subcutaneous injection, three times per week over 14 days starting 9 days before tumour implantation. Solid DS-sarcomas were induced by injecting DS-sarcoma cells (0.4 mL, approximately 104 cells/uL) subcutaneously into the hind food dorsum. A prolonged anaemia was induced in all animals by a single i.v. dose of carboplatin (45 mg/kg dissolved in isotonic saline at a concentration of 20 mg/mL) into the tail vein 3 days before tumour implantation.
Result: Prevented anaemia and significantly increased the radiosensitivity of solid growing DS-sarcomas, tumours showing pronounced hypoxia even under non-anaemic control conditions.
CAS No.
SMILES

[Epoetin beta]

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Epoetin beta
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HY-114134
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