1. Epigenetics
    TGF-beta/Smad
    Cell Cycle/DNA Damage
    Stem Cell/Wnt
    Cytoskeleton
  2. PKC
    ROCK
  3. CRT0066854

CRT0066854 

Cat. No.: HY-18713 Purity: ≥99.0%
Handling Instructions

CRT0066854 is a potent and selective atypical PKC isoenzymes inhibitor. CRT0066854 is against full-length (FL) PKCι, PKCζ, and ROCK-II kinases with IC50 values of 132 nM, 639 nM, and 620 nM, respectively.

For research use only. We do not sell to patients.

CRT0066854 Chemical Structure

CRT0066854 Chemical Structure

CAS No. : 1438881-19-6

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1 mg USD 280 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

CRT0066854 is a potent and selective atypical PKC isoenzymes inhibitor. CRT0066854 is against full-length (FL) PKCι, PKCζ, and ROCK-II kinases with IC50 values of 132 nM, 639 nM, and 620 nM, respectively[1].

IC50 & Target[1]

PKCζ

639 nM (IC50)

ROCK2

620 nM (IC50)

In Vitro

CRT0066854 displaces a crucial Asn-Phe-Asp motif that is part of the adenosine-binding pocket and engages an acidic patch used by arginine-rich PKC substrates[1].
CRT0066854 (0.2-1.2 μM; 6 days) is able to restore polarized morphogenesis in the dysplastic H-Ras spheroids, and the maximal proportion of spheroids with PSALs is at the lower dose of 1.2 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

415.55

Formula

C₂₄H₂₅N₅S

CAS No.

1438881-19-6

SMILES

N[[email protected]](CNC1=NC(C2=CC=NC=C2)=NC3=C1C(CCCC4)=C4S3)CC5=CC=CC=C5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (120.32 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4064 mL 12.0322 mL 24.0645 mL
5 mM 0.4813 mL 2.4064 mL 4.8129 mL
10 mM 0.2406 mL 1.2032 mL 2.4064 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: ≥99.0%

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Keywords:

CRT0066854CRT 0066854CRT-0066854PKCROCKProtein kinase CRho-associated protein kinaseRho-associated kinaseRho-kinaseROKapicallumenformationdysplasticInhibitorinhibitorinhibit

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Product Name:
CRT0066854
Cat. No.:
HY-18713
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