1. Epigenetics
    TGF-beta/Smad
    Cell Cycle/DNA Damage
    Stem Cell/Wnt
    Cytoskeleton
  2. PKC
    ROCK
  3. CRT0066854 hydrochloride

CRT0066854 hydrochloride 

Cat. No.: HY-18713A
Handling Instructions

CRT0066854 hydrochloride is a potent and selective atypical PKCs inhibitor. CRT0066854 is against full-length (FL) PKCι, PKCζ, and ROCK-II kinases with IC50 values of 132 nM, 639 nM, and 620 nM, respectively.

For research use only. We do not sell to patients.

CRT0066854 hydrochloride Chemical Structure

CRT0066854 hydrochloride Chemical Structure

CAS No. : 2250019-91-9

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Description

CRT0066854 hydrochloride is a potent and selective atypical PKCs inhibitor. CRT0066854 is against full-length (FL) PKCι, PKCζ, and ROCK-II kinases with IC50 values of 132 nM, 639 nM, and 620 nM, respectively[1].

IC50 & Target[1]

PKCζ

639 nM (IC50)

ROCKII

620 nM (IC50)

In Vitro

CRT0066854 hydrochloride displaces a crucial Asn-Phe-Asp motif that is part of the adenosine-binding pocket and engages an acidic patch used by arginine-rich PKC substrates[1].
CRT0066854 hydrochloride (0.2-1.2 μM; 6 days) is able to restore polarized morphogenesis in the dysplastic H-Ras spheroids, and the maximal proportion of spheroids with PSALs is at the lower dose of 1.2 μM[1].

Molecular Weight

452.01

Formula

C₂₄H₂₆ClN₅S

CAS No.

2250019-91-9

SMILES

N[[email protected]](CNC1=NC(C2=CC=NC=C2)=NC3=C1C(CCCC4)=C4S3)CC5=CC=CC=C5.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

CRT0066854CRT 0066854CRT-0066854PKCROCKProtein kinase CRho-associated protein kinaseRho-associated kinaseRho-kinaseROKapicallumenformationdysplasticInhibitorinhibitorinhibit

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CRT0066854 hydrochloride
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HY-18713A
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