SERPINA10 - serpin family A member 10 Gene

Also Known as PZI; ZPI

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51156

About SERPINA10

Cytogenetic location: 14q32.13 Genomic coordinates (GRCh38): 14:94,280,460-94,293,268 (from NCBI)

This gene has 4 transcripts (splice variants), 1 gene allele, 256 orthologues, 36 paralogues and is associated with 1 phenotype. Restricted expression toward liver (RPKM 44.6).

Summary

The protein encoded by this gene belongs to the Serpin family. It is predominantly expressed in the liver and secreted in plasma. It inhibits the activity of coagulation factors Xa and XIa in the presence of protein Z, calcium and phospholipid. Mutations in this gene are associated with venous thrombosis. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, May 2010]

SERPINA10 Products (2)

mRNA Protein Name
NM_001100607.3 NP_001094077.1 protein Z-dependent protease inhibitor precursor
NM_016186.3 NP_057270.1 protein Z-dependent protease inhibitor precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
20427285 GOA
Biological Process GO Annotation Evidence References Source
NOT involved in regulation of acrosome reaction IDA
IDA: Inferred from direct assay
11751269 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SERPINA10 Protein Structure

Serpin

Serpin: Serpin (serine protease inhibitor) (79 - 441)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 444 a.a.
Protein Preferred Names Protein Names

protein Z-dependent protease inhibitor

  • PZ-dependent protease inhibitor

SERPINA10 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SERPINA10 Q9UK55 PROZ Homo sapiens P22891
Comig Non-Denat Gel
20427285
Intra
SERPINA10 Q9UK55 PROZ Homo sapiens P22891
X-Ray Diffraction
20427285
Intra
SERPINA10 Q9UK55 PROZ Homo sapiens P22891
Affinity Techniques
20427285
Intra
SERPINA10 Q9UK55 PROZ Homo sapiens P22891
Fluorescence
20427285
Intra
SERPINA10 Q9UK55 F10 Homo sapiens P00742
Affinity Techniques
20427285
Intra
SERPINA10 Q9UK55 F10 Homo sapiens P00742
Comig Non-Denat Gel
20427285
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SERPINA10 Proteins

Cat. No. Product Name Accession Purity
HY-P71292 Serpin A10 Protein, Human (HEK293, His) Q9UK55 (L22-L444) ≥ 95%, as determined by reducing SDS-PAGE.

SERPINA10 Antibodies

Cat. No. Product Name Application Reactivity
HY-P89695 ZPI Antibody (YA9039) WB, ICC/IF, IF-Tissue, IP, ELISA human

Related Diseases

Diseases Alias
Thrombosis

  • Thrombosis Of Blood Vessel
Protein Z Deficiency
Thrombophilia

  • Hypercoagulability State
Shwartzman Phenomenon

  • Shwartzman Reaction
Amelogenesis Imperfecta

  • Ai

  • Congenital Enamel Hypoplasia

  • Al - [Amelogenesis Imperfecta]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12697 SERPINA10 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19294 Serpina10 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25784 Serpina10 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SERPINA10 RGD RGD:621220
Mus musculus SERPINA10 MGD MGI:2667725
Macaca mulatta SERPINA10 VGNC VGNC:77242
Bos taurus SERPINA10 VGNC VGNC:34465
Others SERPINA10 NCBI