PF-4479745
PF-4479745 is a potent and selective 5-HT2C receptor agonist (EC50: 10 nM, ki: 15 nM). PF-4479745 can be used in the research of cardiovascular disease like hypertension.
For research use only. We do not sell to patients.
- CAS No.: 1065110-43-1
- Formula: C17H22N4
- Molecular Weight:282.38
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All 5-HT Receptor Isoforms
More
Biological Activity
|
5-HT2C Receptor |
5-HT2C Receptor 10 nM (EC50) |
5-HT2C Receptor 15 nM (Ki) |
5-HT2A Receptor 360 nM (IC50) |
5-HT2B Receptor 67 nM (IC50) |
5-HT1A Receptor 500 nM (IC50) |
5-HT6 Receptor 280 nM (IC50) |
PF-4479745 (copmpound 17) exhibits metabolic stability in both human liver microsomes (HLM) and human hepatocytes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
PF-4479745 demonstrates a robust dose-dependent effect in canine PUP (peak urethral pressure) model of SUI (stress urinary incontinence)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1065110-43-1
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Molecular Weight 282.38
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Formula C17H22N4
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SMILES
CNC1=C2C([C@H](CNCC2)C)=NC(CC3=CC=CC=C3)=N1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PF-4479745 Related Classifications
HY-118339 Related Classifications
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