Referencia número: HY-17566

Capreomycin sulfate

5 Cited Publications

Revisión del cliente

Based on 5 publication(s) in Google Scholar

Capreomycin sulfate is a macrocyclic peptide antibiotic that inhibits phenylalanine synthesis in mycobacterial ribosomal translation. Capreomycin sulfate has anti-amyloidogenic and pro-fibrinolytic activities, reducing amyloid-induced cytotoxicity by inhibiting the occurrence of amyloid fibrillation. Capreomycin sulfate can be used in the study of multidrug-resistant tuberculosis, type 2 diabetes, Alzheimer's disease and Parkinson's disease.

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Pureza: 99.0%
No. CAS: 1405-37-4

Almacenamiento:

-20°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Capreomycin sulfate Chemical Structure

No. CAS: 1405-37-4

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Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (5)
Solvente y solubilidad
- In Vitro
- In Vivo
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

IC₅₀ & Target

Aminoglycoside

Ver todos los productos específicos de isoformas Antibiotic :

In Vitro

Capreomycin sulfate (10-200 μM; 80 h) inhibits the formation of insulin fibrils in human erythrocytes in a concentration-dependent manner (IC₅₀=69.98 μM) and has a delayed fibrillation process^[3].
Capreomycin sulfate (75-100 μM; 60 min) shows a dose-dependent protective effect against amyloid fibril-induced erythrocyte damage and hemolysis^[3].
Capreomycin sulfate (100 μM; 0-48 h) effectively destroys fibrils in erythrocytes in a time-dependent manner^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[3]

Cell Line:

human erythrocyte
Concentration:

75 and 100 µM
Incubation Time:

30 min
Result:

The hemolysis rates were 23.8% and 13.0% at 75µM and 100µM, respectively.

In Vivo

Capreomycin sulfate (1.4-14.5 mg/kg for insufflation; 20 mg/kg for i.m., 4 weeks) decreases the wet lung weight and lowers bacterial burden in the lungs of infected guinea pigs^[2].

Pharmacokinetic Analysis in the guinea pig model^[2]

Route	Dose (mg/kg)	AUC_0-t (ng h/mL)	CL_F (mL/h kg)	K (h^-1)	t_1/2 (h)	MRT (h)	C_max (ng/mL)	T_max (h)	MAT (h)	F_0-t
i.v.	20	49.29	0.42	0.92	0.75	0.88	53.36	0.08	/	1.00
i.m.	20	58.2	0.35	0.68	1.09	1.44	32.33	0.36	0.44	1.20
Insufflation	14.5	16.95	0.54	0.48	1.53	1.80	6.70	0.31	0.80	0.54
Insufflation	7.2	8.2	0.52	0.45	1.68	1.72	3.34	0.38	0.72	0.59
Insufflation	1.4	1.15	0.67	0.71	1.22	1.01	0.92	0.5	/	0.41

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male guinea pigs [836 ± 162.3 g; infected via the respiratory route with nebulized suspensions 2 × 105 CFU/mL of Mycobacterium tuberculosis (strain H37Rv)] ^[2]
Dosage:

1.4, 7.2, and 14.5 mg/kg for Insufflation; 20 mg/kg for Intramuscular injection
Administration:

Insufflation or Intramuscular injection; 4 weeks
Result:

Decreased the wet lung weight at 14.5 mg/kg, and smaller than receiving 1.4 mg/kg group and controls.
Lowered bacterial burden in the lungs (3.52 CFU/mL) at 14.5 mg/kg than controls (4.58 CFU/mL) and at 1.4 and 7.2 mg/kg (4.02 and 4.01 CFU/mL, respectively)

Chemical Information

No. CAS 1405-37-4
Appearance Solid
Color White to off-white
SMILES

OS(O)(=O)=O.[R]C[C@H](N1)C(N[C@@H](CNC(CC(N)CCCN)=O)C(N/C(C(N[C@H](C(NC[C@H](N)C1=O)=O)[C@@H]2NC(NCC2)=N)=O)=C\NC(N)=O)=O)=O.OS(O)(=O)=O.[R=OH 1A].[R=H 1B]
Structure Classification
- Antibiotics
- Other Antibiotics
- Antibiotics
- Mammalian Cell Culture
Initial Source
- Microorganisms
Streptomyces capreolus
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

-20°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (5)

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Journal Impact Factor

EBioMedicine

Diverse impacts of different rpoB mutations on the anti-tuberculosis efficacy of capreomycin. [Abstract]

2025 May 30:117:105776. PMID: 40449326
mLife

Identification of a phenyl ester covalent inhibitor of caseinolytic protease and analysis of the ClpP1P2 inhibition in mycobacteria. [Abstract]

2025 Apr 15;4(2):155-168. PMID: 40313980
ACS Chem Biol

Investigate Natural Product Indolmycin and the Synthetically Improved Analogue Toward Antimycobacterial Agents. [Abstract]

2022 Jan 21;17(1):39-53. PMID: 34908399
Tuberculosis

The rv2820c K114N mutation is related with capreomycin tolerance. [Abstract]

2024 Jul 26:148:102551. PMID: 39084000
bioRxiv

2025 May 30.

Solvente y solubilidad

In Vitro:

H₂O : 100 mg/mL (Need ultrasonic)

View the Complete Stock Solution Preparation Table

In Vivo:

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS

Solubility: 100 mg/mL; Clear solution; Need ultrasonic

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (282 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Maus CE, et al. Mutation of tlyA confers capreomycin resistance in Mycobacterium tuberculosis. Antimicrob Agents Chemother. 2005 Feb;49(2):571-7. [Content Brief]

[2]. Garcia-Contreras L, et al. Inhaled large porous particles of capreomycin for treatment of tuberculosis in a guinea pig model. Antimicrob Agents Chemother. 2007 Aug;51(8):2830-6. [Content Brief]

[3]. Siddiqi M K, et al. Capreomycin inhibits the initiation of amyloid fibrillation and suppresses amyloid induced cell toxicity[J]. Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics, 2018, 1866(4): 549-557. [Content Brief]

[4]. Reisfeld B, et al. A physiologically based pharmacokinetic model for capreomycin[J]. Antimicrobial agents and chemotherapy, 2012, 56(2): 926-934. [Content Brief]

[5]. Le Conte P, et al. Pharmacokinetics, toxicity, and efficacy of liposomal capreomycin in disseminated Mycobacterium avium beige mouse model[J]. Antimicrobial agents and chemotherapy, 1994, 38(12): 2695-2701. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

Capreomycin sulfate

5 Cited Publications

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Capreomycin sulfate

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Publications Citing Use of MedChemExpress (MCE) Capreomycin sulfate

Ver todos los productos específicos de isoformas Antibiotic

Actividad biológica

Chemical Information

Publications (5)

Solvente y solubilidad

Pureza y Documentación

Referencias

Calculators

Help & FAQs

Capreomycin sulfate Related Classifications

HY-17566 Related Classifications