Antimalarial agent 38
Based on 1 Customer Validation
Antimalarial agent 38 is an orally active antimalarial agent, which inhibits Plasmodium falciparum D6 strain, Chloroquine (HY-17589A)-sensitive Thai strain and Chloroquine-resistant FcB1 strain and K1 strain, with IC50s of 0.5, 13, 1 and 13 μM, respectively. Antimalarial agent 38 is non-cytotoxic for mammalian cells MCR58 (IC50 >140 μM). Antimalarial agent 38 improves the survival rate of Plasmodium yoelii nigeriensis infected mouse model.
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- No. CAS: 123580-46-1
- Fòrmula: C36H40N2O12
- Peso molecular:692.71
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Almacenamiento:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| K562 | IC50 |
>20 μM
Compound: 29
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Ability to potentiate DOX cytotoxicity on K562/DOX MDR cells. Cell survival was assayed by MTT conversion
Ability to potentiate DOX cytotoxicity on K562/DOX MDR cells. Cell survival was assayed by MTT conversion
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[PMID: 9986718] |
| MRC5 | IC50 |
>70 μM
Compound: 1
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Cytotoxicity against MRC5 cells
Cytotoxicity against MRC5 cells
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[PMID: 17166718] |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Plasmodium yoelii nigeriensis N67 infected mice [1]
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Dosage:10 mg/kg, 50 mg/kg
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Administration:p.o; daily; 4 days
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Result:Showed dose-dependent reduction of parasitemia (around 40% of parasite growth inhibition at 50 mg/kg/day).
Chemical Information
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No. CAS 123580-46-1
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Appearance Solid
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Peso molecular 692.71
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Fòrmula C36H40N2O12
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SMILES
O=C(COC1=C(OC)C=CC(C(OC2=C3C(O)=CC(OCC(N4CCN(CC4)CC5=CC=C(C(OC)=C5OC)OC)=O)=C2)=CC3=O)=C1)OCC
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvente y solubilidad
DMSO : 100 mg/mL (144.36 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (3.61 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (269 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.4436 mL | 7.2180 mL | 14.4361 mL | 36.0901 mL |
| 5 mM | 0.2887 mL | 1.4436 mL | 2.8872 mL | 7.2180 mL | |
| 10 mM | 0.1444 mL | 0.7218 mL | 1.4436 mL | 3.6090 mL | |
| 15 mM | 0.0962 mL | 0.4812 mL | 0.9624 mL | 2.4060 mL | |
| 20 mM | 0.0722 mL | 0.3609 mL | 0.7218 mL | 1.8045 mL | |
| 25 mM | 0.0577 mL | 0.2887 mL | 0.5774 mL | 1.4436 mL | |
| 30 mM | 0.0481 mL | 0.2406 mL | 0.4812 mL | 1.2030 mL | |
| 40 mM | 0.0361 mL | 0.1805 mL | 0.3609 mL | 0.9023 mL | |
| 50 mM | 0.0289 mL | 0.1444 mL | 0.2887 mL | 0.7218 mL | |
| 60 mM | 0.0241 mL | 0.1203 mL | 0.2406 mL | 0.6015 mL | |
| 80 mM | 0.0180 mL | 0.0902 mL | 0.1805 mL | 0.4511 mL | |
| 100 mM | 0.0144 mL | 0.0722 mL | 0.1444 mL | 0.3609 mL |
Antimalarial agent 38 Related Classifications
HY-157892 Related Classifications
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