BIRT 377
Based on 4 publication(s) in Google Scholar
BIRT 377 is a potent amd orally bioavailable inhibitor of the interaction between intercellular adhesion molecule-1 (ICAM-1) and lymphocyte function-associated antigen-1 (LFA-1). BIRT 377 also inhibits the production of IL-2 in vivo. BIRT 377 can be used for researching inflammatory and immune disorders.
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- Pureza: 99.82%
- No. CAS: 213211-10-0
- Fòrmula: C18H15BrCl2N2O2
- Peso molecular:442.13
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Publications Citing Use of MedChemExpress (MCE) BIRT 377
More
Actividad biológica
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IL-2 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| H1-HeLa | IC50 |
26 nM
Compound: BIRT-377
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Inhibitory concentration against leukocyte function-associated antigen-1 in HSB-2 human lymphoblast and H1HeLa cell adhesion assay
Inhibitory concentration against leukocyte function-associated antigen-1 in HSB-2 human lymphoblast and H1HeLa cell adhesion assay
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[PMID: 15686933] |
| JY | IC50 |
0.24 μM
Compound: 1
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Concentration required to inhibit aggregation of JY cells
Concentration required to inhibit aggregation of JY cells
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[PMID: 15481974] |
BIRT 377 (20 μM, 6 h) inhibits the mRNA and protein expression of EMT-related markers ZEB2 and Vementin in HT-29 cell whem cocultured with LAD2 cell[2].
BIRT 377 (20 μM, 24 h) inhibits the cell migration of HT-29, when cocultured with LAD2[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HT-29
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Concentration:20 μM
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Incubation Time:6 h
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Result:Inhibited the protein expression of ZEB2 and Vementin.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:hPBMC-injected mouse models[3]
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Dosage:3-10 mg/kg
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Administration:po, once daily for 14 days
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Result:Inhibited the production of human IgG.
Chemical Information
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No. CAS 213211-10-0
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Appearance Solid
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Peso molecular 442.13
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Fòrmula C18H15BrCl2N2O2
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Color White to off-white
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SMILES
O=C1N(C2=CC(Cl)=CC(Cl)=C2)C(N(C)[C@]1(C)CC3=CC=C(Br)C=C3)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (4)
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Journal Impact Factor
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Most Recent
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Anal Chem
Exposome-Scale Investigation of Cl-/Br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multistage Machine Learning, and Cloud Computing. [Abstract]2025 Jun 3;97(21):11099-11109. PMID: 40401576 -
PNAS Nexus
Low-affinity LFA1-dependent outside-in signaling mediates avidity modulation via the Rabin8-Rab8 axis. [Abstract]2024 Aug 8;3(8):pgae332. PMID: 39170909 -
bioRxiv
Mast cells interact directly with colorectal cancer cells to promote epithelial-to-mesenchymal transition. [Abstract]2025 Mar 19:2025.03.19.644113. PMID: 40166179 -
Solvente y solubilidad
DMSO : 100 mg/mL (226.18 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (276 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Kelly TA, et al. Cutting edge: a small molecule antagonist of LFA-1-mediated cell adhesion. J Immunol. 1999;163(10):5173-5177. [Content Brief]
[3]. Winquist RJ, et al., The role of leukocyte function-associated antigen-1 in animal models of inflammation. Eur J Pharmacol. 2001 Oct 19;429(1-3):297-302. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2618 mL | 11.3089 mL | 22.6178 mL | 56.5445 mL |
| 5 mM | 0.4524 mL | 2.2618 mL | 4.5236 mL | 11.3089 mL | |
| 10 mM | 0.2262 mL | 1.1309 mL | 2.2618 mL | 5.6544 mL | |
| 15 mM | 0.1508 mL | 0.7539 mL | 1.5079 mL | 3.7696 mL | |
| 20 mM | 0.1131 mL | 0.5654 mL | 1.1309 mL | 2.8272 mL | |
| 25 mM | 0.0905 mL | 0.4524 mL | 0.9047 mL | 2.2618 mL | |
| 30 mM | 0.0754 mL | 0.3770 mL | 0.7539 mL | 1.8848 mL | |
| 40 mM | 0.0565 mL | 0.2827 mL | 0.5654 mL | 1.4136 mL | |
| 50 mM | 0.0452 mL | 0.2262 mL | 0.4524 mL | 1.1309 mL | |
| 60 mM | 0.0377 mL | 0.1885 mL | 0.3770 mL | 0.9424 mL | |
| 80 mM | 0.0283 mL | 0.1414 mL | 0.2827 mL | 0.7068 mL | |
| 100 mM | 0.0226 mL | 0.1131 mL | 0.2262 mL | 0.5654 mL |
BIRT 377 Related Classifications
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