CNR2 - cannabinoid receptor 2 Gene

Also Known as CB2; CX5; CB-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1269

About CNR2

Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:23,870,515-23,913,362 (from NCBI)

This gene has 1 transcript (splice variant), 196 orthologues and 18 paralogues. Biased expression in lymph node (RPKM 3.7), spleen (RPKM 3.4) and 4 other tissues.

Summary

The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins encoded by this gene and the Cannabinoid Receptor 1 (brain) (CNR1) gene have the characteristics of a guanine nucleotide-binding protein (G-protein)-coupled receptor for cannabinoids. They inhibit Adenylate Cyclase activity in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. The cannabinoid receptors are members of family 1 of the G-protein-coupled receptors. [provided by RefSeq, Jul 2008]

CNR2 Products (4)

mRNA Protein Name
XM_047444833.1 XP_047300789.1 cannabinoid receptor 2 isoform X1
XM_017000261.3 XP_016855750.1 cannabinoid receptor 2 isoform X1
NM_001841.3 NP_001832.1 cannabinoid receptor 2
XM_011540629.4 XP_011538931.1 cannabinoid receptor 2 isoform X1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Referencias Source
enables protein binding IPI
IPI: Inferred from physical interaction
31616248 GOA
Cellular Component GO Annotation Evidence Referencias Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
28364261 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CNR2 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (50 - 299)

  • 0
  • 100
  • 200
  • 300
  • 360 a.a.
Protein Preferred Names Protein Names

cannabinoid receptor 2

  • cannabinoid receptor 2 (macrophage)

CNR2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Referencias
Intra
CNR2 P34972 NRM Homo sapiens Q8IXM6
Validated Y2H
32296183
Intra
CNR2 P34972 TMEM242 Homo sapiens Q9NWH2
Validated Y2H
32296183
Intra
CNR2 P34972 ADIPOQ Homo sapiens Q15848
Validated Y2H
32296183
Intra
CNR2 P34972 TMPPE Homo sapiens Q6ZT21
Validated Y2H
32296183
Intra
CNR2 P34972 TMEM86A Homo sapiens Q8N2M4
Validated Y2H
32296183
Intra
CNR2 P34972 ADAM21 Homo sapiens Q9UKJ8
Validated Y2H
32296183
Intra
CNR2 P34972 FXYD3 Homo sapiens Q14802-3
Validated Y2H
32296183
Intra
CNR2 P34972 TSPO2 Homo sapiens Q5TGU0
Validated Y2H
32296183
Intra
CNR2 P34972 TMEM203 Homo sapiens Q969S6
Validated Y2H
32296183
Intra
CNR2 P34972 SLC35E4 Homo sapiens Q6ICL7
Validated Y2H
32296183
Intra
CNR2 P34972 SLC39A2 Homo sapiens Q9NP94
Validated Y2H
32296183
Intra
CNR2 P34972 AGPAT4 Homo sapiens Q9NRZ5
Validated Y2H
32296183
Intra
CNR2 P34972 MUC15 Homo sapiens Q8N387
Validated Y2H
32296183
Intra
CNR2 P34972 TMEM60 Homo sapiens Q9H2L4
Validated Y2H
32296183
Intra
CNR2 P34972 SQSTM1 Homo sapiens Q13501
Anti Tag CoIP
31616248
Intra
CNR2 P34972 RFT1 Homo sapiens Q96AA3
Validated Y2H
32296183
Intra
CNR2 P34972 TMEM19 Homo sapiens Q96HH6
Validated Y2H
32296183
Intra
CNR2 P34972 YIPF6 Homo sapiens Q96EC8
Validated Y2H
32296183
Intra
CNR2 P34972 YIPF4 Homo sapiens Q9BSR8
Validated Y2H
32296183
Intra
CNR2 P34972 YIPF1 Homo sapiens Q9Y548
Validated Y2H
32296183
Intra
CNR2 P34972 SELENOK Homo sapiens Q9Y6D0
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CNR2 Proteins

Referencia número Nombre del producto Accession Pureza
HY-P700636 CNR2 Protein-VLP, Human (HEK293) P34972 (M1-C360) ≥ 95%, as determined by HPLC.

CNR2 Antibodies

Referencia número Nombre del producto Aplicación Reactivity
HY-P811295 CB2 Antibody WB, IHC-P Human, Mouse, Rat

Related Diseases

Diseases Alias
Chlorhexidine Allergy
Purulent Labyrinthitis

  • Suppurative Labyrinthitis

  • Acute Suppurative Labyrinthitis

  • Bacterial Labyrinthitis
Osteoporosis

  • Postmenopausal Osteoporosis

  • Osteoporosis, Postmenopausal

  • Bone Mineral Density Quantitative Trait Locus

  • Bmnd

  • Osteoporosis, Involutional

  • Osteoporosis, Susceptibility To

  • Osteoporosis, Postmenopausal, Susceptibility

  • Bone Mineral Density Variation Qtl, Osteoporosis

  • OSTEOP

  • Involutional Osteoporosis

  • Senile Osteoporosis

  • Osteoporosis Postmenopausal

  • Bone Mineral Density, Quantitative Trait Locus

  • Osteoporosis, Senile

  • Idiopathic Osteoporosis

  • Bone Rarefaction Nos

  • Type 1 Osteoporosis
Multiple Sclerosis

  • MS

  • Multiple Sclerosis, Susceptibility To

  • Disseminated Sclerosis

  • Multiple Sclerosis, Disease Progression, Modifier Of

  • Insular Sclerosis

  • Multiple Sclerosis Modifier Of Disease Progression

  • Multiple Sclerosis, Susceptibility To 1

  • Multiple Sclerosis, Susceptibility To, 1

  • Multiple Sclerosis 1

  • Generalized Multiple Sclerosis

  • Multiple Sclerosis Variant

  • Multiple Sclerosis Susceptibility To

  • Cerebrospinal Sclerosis

  • Generalised Multiple Sclerosis

  • Ms - [Multiple Sclerosis]

  • Disseminated Cerebrospinal Sclerosis

  • Disseminated Multiple Sclerosis

  • Disseminated Nervous System Myelosclerosis

  • Multiple Cerebrospinal Sclerosis

  • Multiple Combined Sclerosis

  • Multiple Sclerosis Generalised

  • Disseminated Brain Sclerosis

  • Disseminated Spinal Sclerosis

  • Insular Brain Sclerosis

  • Miliary Brain Sclerosis

  • Multiple Combined Sclerosis Of Spinal Cord

  • Multiple Ascending Sclerosis

  • Multiple Brain Sclerosis

  • Multiple Sclerosis Of Brain Stem

  • Multiple Sclerosis Of The Brain Stem

  • Multiple Sclerosis Of Cord

  • Sclérose En Plaques

  • Plaque Sclerosis

  • Multiple Sclerosis Of The Spinal Cord
Alzheimer Disease, Familial, 1

  • Alzheimer Disease

  • Alzheimer'S Disease

  • Presenile And Senile Dementia

  • AD1

  • Alzheimer Disease, Susceptibility To

  • Alzheimer Disease, Late-Onset, Susceptibility To

  • Alzheimer Disease 1, Familial

  • AD

  • Familial Alzheimer Disease

  • Alzheimer Disease, Late-Onset

  • Alzheimers Dementia

  • Alzheimer Dementia

  • Alzheimer Sclerosis

  • Alzheimer Syndrome

  • Alzheimer-Type Dementia

  • Dat

  • Primary Senile Degenerative Dementia

  • Sdat

  • Alzheimer Disease 1

  • Autosomal Dominant Alzheimer Disease

  • Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

  • Late Onset Alzheimer Disease

  • Alzheimers Disease

  • Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

  • Late-Onset Alzheimers Disease

  • Alzheimer'S Disease Pathway Kegg

  • Dementia Due To Alzheimer'S Disease

  • Alzheimer Disease Type 1

  • Alzheimers
Body Mass Index Quantitative Trait Locus 11

  • OBESITY

  • Obesity, Susceptibility To

  • Leanness, Inherited

  • Obesity, Susceptibility To, Bmiq11

  • Obesity, Mild, Early-Onset

  • Obesity, Association With

  • Obesity, Early-Onset, Susceptibility To

  • Obesity, Severe

  • Obesity, Severe, And Type Ii Diabetes

  • Obesity, Late-Onset

  • BMIQ11

  • Obesity Bmiq11

  • Obesity, Early-Onset

  • Obesity , Susceptibility To

  • Simple Obesity Nos

  • Excess Fat

  • Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

  • Adiposis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Referencia número Nombre del producto
Efecto
Pureza
Rare Diseases
HY-153169 6PPD-Q Inhibitor 99.77% Unkown
HY-Y1322 Triphenyl phosphate 99.67% Unkown
HY-107713 PPDA Antagonist 98.0% Unkown
HY-RS02917 CNR2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS02918 Cnr2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS02919 Cnr2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus CNR2 VGNC VGNC:27530
Canis familiaris CNR2 VGNC VGNC:39427
Mus musculus CNR2 MGD MGI:104650
Felis catus CNR2 VGNC VGNC:80173
Macaca mulatta CNR2 VGNC VGNC:71281
Rattus norvegicus CNR2 RGD RGD:619713
Others CNR2 NCBI