CB2 Antibody
(Synonyms: CB2A, CB2B, CNR2, Cannabinoid receptor 2, CB-2, CB2, hCB2, CX5)CB2 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to CB2.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:100-200 |
Product Details
CB2 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to CB2.
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 40 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 39 kDa
Synthetic peptide of human CB2.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
CB2 is a Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis
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Subcellular Localization
Cell membrane; Cell projection, dendrite; Perikaryon
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Expression
Tissue_Specificity: Preferentially expressed in cells of the immune system with higher expression in B-cells and NK cells (at protein level). Expressed in skin in suprabasal layers and hair follicles (at protein level). Highly expressed in tonsil and to a lower extent in spleen, peripheral blood mononuclear cells, and thymus. could not detect expression in normal brain. Expressed in brain by perivascular microglial cells and dorsal root ganglion sensory neurons (at protein level). Two isoforms are produced by alternative promoter usage and differ only in the 5' UTR: isoform CB2A is observed predominantly in testis with some expression in brain, while isoform CB2B is predominant in spleen and leukocytes.
Induction: In macrophages, down-regulated by endocannabinoid anandamide/AEA. -
Isoforms & Post-Translational Modification
CB2 has an amino acid length of 360, molecular weight is 39681 Da.第 352 位丝氨酸(Ser-352)会发生组成型磷酸化；该磷酸化会增加细胞内吞并使受体脱敏CB2 的氨基酸个数为 360 个，分子量为 39681 Da。Constitutively phosphorylated on Ser-352; phosphorylation increases cell internalization and desensitizes the receptor
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SwissProt ID
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Synonyms
CB2A, CB2B, CNR2, Cannabinoid receptor 2, CB-2, CB2, hCB2, CX5
Documentation
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