Isopentaquine
Isopentaquine is an orally active antimalarial agent. Isopentaquine induces mild morphological changes in the exoerythrocytic stage of Plasmodium fallax, with a ED50 of 6.7 mg/L. Isopentaquine causes degenerative changes in the development of Plasmodium oocysts in infected mosquitoes. Isopentaquine reduces the infectivity of Plasmodium falciparum gametocytes. Isopentaquine impairs sympathetic cardiovascular reflexes. Isopentaquine decreases the recurrence rate and total disease duration of Plasmodium vivax infection. Isopentaquine can be used in malaria-related research.
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- No. CAS: 529-73-7
- Fòrmula: C18H27N3O
- Peso molecular:301.43
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
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Plasmodium |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MCF7 | IC50 |
14.4 μM
Compound: 19g, SID 24724375
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Inhibition of Hsp90 in human MCF7 cell lysates assessed as interaction with Cy3b-conjugated geldanamycin by FP assay
Inhibition of Hsp90 in human MCF7 cell lysates assessed as interaction with Cy3b-conjugated geldanamycin by FP assay
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[PMID: 18571929] |
Isopentaquine (10-20 mg/L; 48 h) induces mild morphological changes in exoerythrocytic stages of Plasmodium fallax grown in embryonic turkey brain cells, with an ED50 of 6.7 mg/l, making it less effective than other tested 8-aminoquinolines[1].
Isopentaquine reduces the infectivity of Plasmodium falciparum gametocytes[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Isopentaquine (Large doses; prolonged period) impairs sympathetic cardiovascular reflexes in dogs and monkeys via medullary cell group destruction[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:unspecified strain[2]
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Dosage:0.02% concentration
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Administration:oral; via feeding
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Result:Produced degenerative changes in Plasmodium falciparum oocyst development in infected mosquitoes.
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Animal Model:unspecified strains[2]
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Dosage:Large doses
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Administration:prolonged period
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Result:Impaired sympathetic cardiovascular reflexes in dogs and monkeys, believed to be due to destruction of medullary cell groups.
Chemical Information
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No. CAS 529-73-7
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Peso molecular 301.43
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Fòrmula C18H27N3O
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SMILES
N=1C=CC=C2C=C(OC)C=C(NC(C)CCCNC(C)C)C12
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Aikawa M, et al. Morphological effects of 8-aminoquinolines on the exoerythrocytic stages of Plasmodium fallax. Mil Med. 1969 Sep;134(10):986-99. [Content Brief]
[2]. Grewal RS. Pharmacology of 8-aminoquinolines. Bull World Health Organ. 1981;59(3):397-406. [Content Brief]
[3]. van der Meer JW, et al. Abstract!. Neth J Med. 2002;60(11):418. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Isopentaquine Related Classifications
HY-119511 Related Classifications
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