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Referencia número: HY-120688

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L-772405

L-772405 is a selective 5-HT_1D receptor agonist with the K_i values of 318, 29 and ＞ 1000 nM aganist guinea pig 5-HT1_B receptor, guinea pig 5-HT_1D receptor and rat 5-HT rransporter, respectively. L-772405 decreases the potassium-induced outflow of 5-HT with an IC₅₀ value of 240 nM.

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No. CAS: 177947-03-4
Fòrmula: C₂₆H₃₁FN₆O
Peso molecular:462.56

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

L-772405 Chemical Structure

No. CAS: 177947-03-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Pureza y Documentación
Referencias
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Bioz

Actividad biológica

Descripciòn

IC₅₀ & Target

5-HT_1B Receptor

5-HT_1D Receptor

Ver todos los productos específicos de isoformas 5-HT Receptor :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	EC₅₀	0.8 nM Compound: 80	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	[PMID: 10585208]
CHO	IC₅₀	>10000 nM Compound: 80	Compound was tested for the displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1F receptor stably expressed in CHO cells Compound was tested for the displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1F receptor stably expressed in CHO cells	[PMID: 10585208]
CHO	IC₅₀	>10000 nM Compound: 80	Compound was tested for the displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 5A receptor stably expressed in CHO cells Compound was tested for the displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 5A receptor stably expressed in CHO cells	[PMID: 10585208]
CHO	IC₅₀	>10000 nM Compound: 80	Compound was tested for the displacement of [3H]5-HT binding to cloned rat 5-hydroxytryptamine 6 receptor stably expressed in CHO cells Compound was tested for the displacement of [3H]5-HT binding to cloned rat 5-hydroxytryptamine 6 receptor stably expressed in CHO cells	[PMID: 10585208]
CHO	IC₅₀	0.9 nM Compound: 80	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	[PMID: 10585208]
CHO	IC₅₀	1100 nM Compound: 80	Compound was tested for the displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 2A receptor stably expressed in CHO cells Compound was tested for the displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 2A receptor stably expressed in CHO cells	[PMID: 10585208]
CHO	IC₅₀	150 nM Compound: 80	Displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cells Displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cells	[PMID: 10585208]
CHO	IC₅₀	540 nM Compound: 80	Compound was tested for the displacement of [3H]5-HT binding to cloned rat 5-hydroxytryptamine 7 receptor stably expressed in CHO cells Compound was tested for the displacement of [3H]5-HT binding to cloned rat 5-hydroxytryptamine 7 receptor stably expressed in CHO cells	[PMID: 10585208]
CHO	IC₅₀	66 nM Compound: 80	Compound was tested for the displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1A receptor stably expressed in CHO cells Compound was tested for the displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1A receptor stably expressed in CHO cells	[PMID: 10585208]
CHO	IC₅₀	>10000 nM Compound: 80	Compound was tested for the displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1E receptor stably expressed in CHO cells Compound was tested for the displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1E receptor stably expressed in CHO cells	[PMID: 10585208]
CHO	EC₅₀	1.1 nM Compound: 6h	Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor. Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.	[PMID: 9357514]
CHO	IC₅₀	0.9 nM Compound: 6h	Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement. Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.	[PMID: 9357514]
CHO	IC₅₀	185 nM Compound: 6h	Binding affinity to human cloned 5-hydroxytryptamine 1B receptor in CHO cells by [3H]5-HT binding displacement. Binding affinity to human cloned 5-hydroxytryptamine 1B receptor in CHO cells by [3H]5-HT binding displacement.	[PMID: 9357514]
CHO	EC₅₀	1.1 nM Compound: 1	Agonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptor Agonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptor	[PMID: 9667955]
CHO	IC₅₀	0.9 nM Compound: 1	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	[PMID: 9667955]

Chemical Information

No. CAS 177947-03-4
Peso molecular 462.56
Fòrmula C₂₆H₃₁FN₆O
SMILES

OC[C@@H](C1=CC=C(C=C1)F)NC(CC2)CCN2CCCC3=CNC4=CC=C(N5C=NN=C5)C=C34
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Pullar IA, et al. The role of the 5-HT1D receptor as a presynaptic autoreceptor in the guinea pig. Eur J Pharmacol. 2004 Jun 16;493(1-3):85-93. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Actividad biológica
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- IC₅₀ & Target
Chemical Information
Pureza y Documentación
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L-772405

Ver todos los productos específicos de isoformas 5-HT Receptor

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

L-772405 Related Classifications

HY-120688 Related Classifications