177947-03-4
Chemical Structure
L-772405
- CAS No.: 177947-03-4
- Formula:C26H31FN6O
- Molecular Weight:462.56
IUPAC Name: (R)-2-((1-(3-(5-(4H-1,2,4-triazol-4-yl)-1H-indol-3-yl)propyl)piperidin-4-yl)amino)-2-(4-fluorophenyl)ethan-1-ol
InChIKey: HNKDAQNYMJNLCC-SANMLTNESA-N
SMILES: OC[C@@H](C1=CC=C(C=C1)F)NC(CC2)CCN2CCCC3=CNC4=CC=C(N5C=NN=C5)C=C34
Biological Activity: L-772405 is a selective 5-HT1D receptor agonist with the Ki values of 318, 29 and ＞ 1000 nM aganist guinea pig 5-HT1B receptor, guinea pig 5-HT1D receptor and rat 5-HT rransporter, respectively. L-772405 decreases the potassium-induced outflow of 5-HT with an IC50 value of 240 nM[1].
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L-772405 | L-772405 is a selective 5-HT1D receptor agonist with the Ki values of 318, 29 and ＞ 1000 nM aganist guinea pig 5-HT1B receptor, guinea pig 5-HT1D receptor and rat 5-HT rransporter, respectively. L-772405 decreases the potassium-induced outflow of 5-HT with an IC50 value of 240 nM. | |||||||||||||||||||||
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Keywords
