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Referencia número: HY-164686

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MMV019662

MMV019662 is a PfNCR1 inhibitor and antimalarial agent. MMV019662 reduces gametocytemia levels of Plasmodium falciparum. MMV019662 is applicable to malaria-related research.

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No. CAS: 896349-19-2
Fòrmula: C₂₇H₃₅N₃O₄
Peso molecular:465.59

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (282 KB)

MMV019662 Chemical Structure

No. CAS: 896349-19-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

MMV019662 is a PfNCR1 inhibitor and antimalarial agent. MMV019662 reduces gametocytemia levels of Plasmodium falciparum. MMV019662 is applicable to malaria-related research^[1]^[2].

IC₅₀ & Target^[1]^[2]

Plasmodium

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Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	Inhibition	1 % Compound: TCMDC-124312	GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM.	[PMID: 20485427]

In Vitro

MMV019662 (3× EC₉₀; 13 days) significantly reduces the total gametocytaemia level of blood-stage gametocytes of Plasmodium falciparum^[1].
MMV019662 (72 h) inhibits the growth of the asexual erythrocytic stage of P. falciparum (Plasmodium falciparum) with an EC₅₀ of 1.18 μM^[1].
MMV019662 (0-100 μM) does not thermostabilize purified PfNCR1^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 896349-19-2
Peso molecular 465.59
Fòrmula C₂₇H₃₅N₃O₄
SMILES

O=C(NCC(C1=CC=C2OCOC2=C1)N3CCN(C4=CC=C(OC)C=C4)CC3)C5CCCCC5
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (282 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Kohling A, et al. Targeting ligand binding sites in Plasmodium falciparum NCR1 enables antimalarial drug discovery. bioRxiv, 2025: 2025.11. 11.687791.

[2]. Zhang Z, et al. The Plasmodium falciparum NCR1 membrane protein is a novel antimalarial target that exports cholesterol to maintain membrane homeostasis. bioRxiv, 2024: 2024.09. 30.615907.

Calculators

Calculadora de molaridad

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Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Actividad biológica
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- IC₅₀ & Target
- In Vitro
Chemical Information
Pureza y Documentación
Referencias

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MMV019662

Ver todos los productos específicos de isoformas Parasite

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

MMV019662 Related Classifications

HY-164686 Related Classifications