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Referencia número: HY-168842

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PRMT5-IN-47

PRMT5-IN-47 (compound 20) is a potent, selectively and orally active, MTA cooperative PRMT5 inhibitor with an IC₅₀ value of 15 nM. PRMT5-IN-47 shows antiproliferative activity. PRMT5-IN-47 shows anticancer activity.

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No. CAS: 3065081-87-7
Fòrmula: C₂₄H₂₂FN₅O₂
Peso molecular:431.46

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

PRMT5-IN-47 Chemical Structure

No. CAS: 3065081-87-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

IC₅₀ & Target^[1]

PRMT5

15 nM (IC₅₀)

Ver todos los productos específicos de isoformas Histone Methyltransferase :

Chemical Information

No. CAS 3065081-87-7
Peso molecular 431.46
Fòrmula C₂₄H₂₂FN₅O₂
SMILES

NC1=NC2=C(C=C(C(F)=C2)C(N(C)[C@H]3CN(CC3)C4=CC=C(C=C4)C#N)=O)C5=C1COC5
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Zhang M, et al. Discovery of Potent, Highly Selective, and Orally Bioavailable MTA Cooperative PRMT5 Inhibitors with Robust In Vivo Antitumor Activity. J Med Chem. 2025 Jan 9. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

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Volume Volume

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Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Actividad biológica
- Descripciòn
- IC₅₀ & Target
Chemical Information
Pureza y Documentación
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PRMT5-IN-47

Ver todos los productos específicos de isoformas Histone Methyltransferase

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

PRMT5-IN-47 Related Classifications

HY-168842 Related Classifications