(Rac)-ALX 5407
NFPS is a selective, non-competitive glycine transporter-1 (GlyT1) inhibitor with IC50s of 2.8 nM and 9.8 nM for hGlyT1 and rGlyT1, respectively. NFPS exerts neuroprotection via glyR alpha1 subunit in the rat model of transient focal cerebral ischaemia and reperfusion.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 405225-21-0
- Fòrmula: C24H24FNO3
- Peso molecular:393.45
-
Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
-
HY-10809
Bitopertin
-
HY-10711A
ALX-5407 hydrochloride
-
HY-112432
GlyT1 Inhibitor 1
-
HY-107527
Org 25543 hydrochloride
-
HY-10809A
Bitopertin (R enantiomer)
-
HY-100416A
LY2365109 hydrochloride
-
HY-10716A
PF-03463275
-
HY-10809R
Bitopertin (Standard)
-
HY-138935
Iclepertin
-
HY-110176
ASP2535
-
HY-10715
SSR504734
-
HY-101037
Sarcosine
Actividad biológica
|
hGlyT1 2.8 nM (IC50) |
rGlyT1 9.8 nM (IC50) |
Chemical Information
-
No. CAS 405225-21-0
-
Peso molecular 393.45
-
Fòrmula C24H24FNO3
-
SMILES
OC(CN(C)CCC(C1=CC=C(F)C=C1)OC2=CC=C(C3=CC=CC=C3)C=C2)=O
-
Synonyms
(Rac)-NFPS
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Mallorga PJ, et al. Pharmacology and expression analysis of glycine transporter GlyT1 with [3H]-(N-[3-(4'-fluorophenyl)-3-(4'phenylphenoxy)propyl])sarcosine. Neuropharmacology. 2003 Oct;45(5):585-93. [Content Brief]
[2]. Huang B, et al. GlyT1 Inhibitor NFPS Exerts Neuroprotection via GlyR Alpha1 Subunit in the Rat Model of Transient Focal Cerebral Ischaemia and Reperfusion. Cell Physiol Biochem. 2016;38(5):1952-62. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(Rac)-ALX 5407 Related Classifications
HY-107526 Related Classifications
Powered by Bioz