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Referencia número: HY-125733

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Thiocillin I

Revisión del cliente

Based on 1 Customer Validation

Thiocillin I is a thiopeptide antibiotic and has in vitro antibacterial activity against Gram-positive bacterial strains. The MIC values of Thiocillin I against S. aureus 1974149, E. faecalis 1674621, B. subtilis ATCC 6633 and S. pyogenes 1744264 are 2 μg/mL, 0.5 μg/mL, 4 μg/mL and 0.5 μg/mL, respectively.

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Pureza: 96.00%
No. CAS: 59979-01-0
Fòrmula: C₄₈H₄₉N₁₃O₁₀S₆
Peso molecular:1160.37

Almacenamiento:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Thiocillin I Chemical Structure

No. CAS: 59979-01-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Bioz

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Descripciòn

IC₅₀ & Target

Bacterial^[1]

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In Vitro

Thiocillin I (2 μM; 24 hours; U-2OS C3 osteosarcoma cells) is not proteasome inhibitor, and does not stabilize expression of multiple cellular proteins and suppresses FoxM1 expression in U-2OS C3 osteosarcoma cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 59979-01-0
Appearance Solid
Peso molecular 1160.37
Fòrmula C₄₈H₄₉N₁₃O₁₀S₆
Color White to off-white
SMILES

C[C@H](C(N1)C2=NC(C3=NC(C4=NC(C5=NC(C(N/C(C(NC[C@H](O)C)=O)=C\C)=O)=CS5)=CS4)=CC=C3C6=NC(C(N[C@@](C(N/C(C7=NC(C(N[C@@H](C(C)(O)C)C8=NC(C1=O)=CS8)=O)=CS7)=C\C)=O)([H])[C@H](O)C)=O)=CS6)=CS2)O
Structure Classification
- Antibiotics
Initial Source
- Microorganisms
the culture broth of Bacillus cereus G-15
Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (281 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Akasapu S, et al. Total synthesis of micrococcin P1 and thiocillin I enabled by Mo(vi) catalyst. Chem Sci. 2018 Dec 3;10(7):1971-1975. [Content Brief]

[2]. Pandit B, et al. Proteasome inhibitory activity of thiazole antibiotics. Cancer Biol Ther. 2011 Jan 1;11(1):43-7. [Content Brief]

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Thiocillin I

Ver todos los productos específicos de isoformas Antibiotic

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Thiocillin I Related Classifications

HY-125733 Related Classifications