VAT1 - vesicle amine transport 1 Gene

Also Known as VATI

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10493

About VAT1

Cytogenetic location: 17q21.31 Genomic coordinates (GRCh38): 17:43,014,607-43,022,385 (from NCBI)

This gene has 9 transcripts (splice variants), 295 orthologues and 17 paralogues. Ubiquitous expression in adrenal (RPKM 107.1), ovary (RPKM 104.4) and 25 other tissues.

Summary

Synaptic vesicles are responsible for regulating the storage and release of neurotransmitters in the nerve terminal. The protein encoded by this gene is an abundant integral membrane protein of cholinergic synaptic vesicles and is thought to be involved in vesicular transport. It belongs to the quinone oxidoreductase subfamily of zinc-containing alcohol dehydrogenase proteins. [provided by RefSeq, Jul 2008]

VAT1 Products (1)

mRNA Protein Name
NM_006373.4 NP_006364.2 synaptic vesicle membrane protein VAT-1 homolog

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of mitochondrial fusion IMP
IMP: Inferred from mutant phenotype
17105775 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VAT1 Protein Structure

ADH_N

ADH_N: Alcohol dehydrogenase GroES-like domain (77 - 136)

ADH_zinc_N

ADH_zinc_N: Zinc-binding dehydrogenase (200 - 327)

  • 0
  • 100
  • 200
  • 300
  • 393 a.a.
Protein Preferred Names Protein Names

synaptic vesicle membrane protein VAT-1 homolog

  • membrane protein of cholinergic synaptic vesicles

VAT1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
VAT1 Q99536 PLP1 Homo sapiens P60201-2
Y2H Array
32296183
Intra
VAT1 Q99536 PLP1 Homo sapiens P60201-2
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-125900 Neocarzilin A 95.82% Unkown
HY-RS13043 SLC18A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15610 VAT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15611 VAT1L Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22912 Vat1l Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29426 Vat1l Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus VAT1 MGD MGI:1349450
Rattus norvegicus VAT1 RGD RGD:1308943
Felis catus VAT1 VGNC VGNC:66923
Macaca mulatta VAT1 VGNC VGNC:79058
Bos taurus VAT1 VGNC VGNC:36770
Canis familiaris VAT1 VGNC VGNC:55836
Others VAT1 NCBI