Neocarzilin A
Based on 1 Customer Validation
Neocarzilin A (NCA) reduces BST-2 levels via lysosomal degradation. Neocarzilin A has antimigratory and antiproliferative effects on cancer cells. Neocarzilin A inhibits cancer cell migration via irreversible binding to the synaptic vesicle membrane protein VAT-1.
For research use only. We do not sell to patients.
- Purity: 95.82%
- CAS No.: 124958-29-8
- Formula: C14H17Cl3O2
- Molecular Weight:323.64
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Storage:Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 124958-29-8
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Appearance Oil
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Molecular Weight 323.64
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Formula C14H17Cl3O2
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Color Light yellow to orange
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SMILES
CC[C@H](C)/C=C/C=C/C=C/C(O)=C/C(C(Cl)(Cl)Cl)=O
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Synonyms
NCA
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Structure Classification
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Initial Source
Streptomyces carzinostaticus
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (308.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (264 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.0899 mL | 15.4493 mL | 30.8985 mL | 77.2463 mL |
| 5 mM | 0.6180 mL | 3.0899 mL | 6.1797 mL | 15.4493 mL | |
| 10 mM | 0.3090 mL | 1.5449 mL | 3.0899 mL | 7.7246 mL | |
| 15 mM | 0.2060 mL | 1.0300 mL | 2.0599 mL | 5.1498 mL | |
| 20 mM | 0.1545 mL | 0.7725 mL | 1.5449 mL | 3.8623 mL | |
| 25 mM | 0.1236 mL | 0.6180 mL | 1.2359 mL | 3.0899 mL | |
| 30 mM | 0.1030 mL | 0.5150 mL | 1.0300 mL | 2.5749 mL | |
| 40 mM | 0.0772 mL | 0.3862 mL | 0.7725 mL | 1.9312 mL | |
| 50 mM | 0.0618 mL | 0.3090 mL | 0.6180 mL | 1.5449 mL | |
| 60 mM | 0.0515 mL | 0.2575 mL | 0.5150 mL | 1.2874 mL | |
| 80 mM | 0.0386 mL | 0.1931 mL | 0.3862 mL | 0.9656 mL | |
| 100 mM | 0.0309 mL | 0.1545 mL | 0.3090 mL | 0.7725 mL |
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