ESM1 - endothelial cell specific molecule 1 Gene

Also Known as endocan

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 11082

About ESM1

Cytogenetic location: 5q11.2 Genomic coordinates (GRCh38): 5:54,977,867-54,985,593 (from NCBI)

This gene has 4 transcripts (splice variants) and 196 orthologues. Biased expression in thyroid (RPKM 12.6), kidney (RPKM 8.9) and 9 other tissues.

Summary

This gene encodes a secreted protein which is mainly expressed in the endothelial cells in human lung and kidney tissues. The expression of this gene is regulated by cytokines, suggesting that it may play a role in endothelium-dependent pathological disorders. The transcript contains multiple polyadenylation and mRNA instability signals. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

ESM1 Products (2)

mRNA Protein Name
NM_001135604.2 NP_001129076.1 endothelial cell-specific molecule 1 isoform b precursor
NM_007036.5 NP_008967.1 endothelial cell-specific molecule 1 isoform a precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables hepatocyte growth factor receptor binding IPI
IPI: Inferred from physical interaction
11590178 GOA
enables integrin binding IPI
IPI: Inferred from physical interaction
11544294 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in angiogenesis IEP
IEP: Inferred from expression pattern
11866539 GOA
involved in positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
11590178 GOA
involved in positive regulation of hepatocyte growth factor receptor signaling pathway IDA
IDA: Inferred from direct assay
11590178 GOA
involved in sprouting angiogenesis IMP
IMP: Inferred from mutant phenotype
20616313 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ESM1 Protein Structure

IGFBP

IGFBP: Insulin-like growth factor binding protein (28 - 83)

  • 0
  • 100
  • 184 a.a.
Protein Preferred Names Protein Names

endothelial cell-specific molecule 1

  • ESM-1

ESM1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ESM1 Q9NQ30 KIF1B Homo sapiens O60333-2
Y2H Array
32814053
Intra
ESM1 Q9NQ30 KIF1B Homo sapiens O60333-2
Y2H Pooling
32814053
Intra
ESM1 Q9NQ30 KIF1B Homo sapiens O60333-2
Validated Y2H
32814053
Intra
ESM1 Q9NQ30 VGLL3 Homo sapiens A8MV65-2
Y2H Prey Pooling
32296183
Intra
ESM1 Q9NQ30 VGLL3 Homo sapiens A8MV65-2
Y2H Array
32296183
Intra
ESM1 Q9NQ30 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
ESM1 Q9NQ30 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
ESM1 Q9NQ30 RNF11 Homo sapiens Q9Y3C5
Y2H Array
32814053
Intra
ESM1 Q9NQ30 RNF11 Homo sapiens Q9Y3C5
Y2H Pooling
32814053
Intra
ESM1 Q9NQ30 RNF11 Homo sapiens Q9Y3C5
Validated Y2H
32814053
Intra
ESM1 Q9NQ30 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra
ESM1 Q9NQ30 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra
ESM1 Q9NQ30 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Intra
ESM1 Q9NQ30 HOXA1 Homo sapiens P49639
Y2H Prey Pooling
32296183
Intra
ESM1 Q9NQ30 HOXA1 Homo sapiens P49639
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ESM1 Proteins

Cat. No. Product Name Accession Purity
HY-P70151 ESM-1 Protein, Human (HEK293, His) Q9NQ30-1/AAH11989.1 (W20-R184 ) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P75219 ESM-1 Protein, Human (sf9, His) Q9NQ30-1/NP_008967.1 (W20-R184) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Gastric Cancer

  • Stomach Cancer

  • Gastric Carcinoma

  • Stomach Carcinoma

  • Gastric Cancer, Somatic

  • Gastric Neoplasm

  • Carcinoma Of Stomach

  • Stomach Neoplasms

  • Malignant Neoplasm Of Stomach

  • Gastric Cancer Risk After H. Pylori Infection

  • Cancer Of The Stomach

  • Adult Stomach Cancer

  • Adult Stomach Carcinoma

  • GASC

  • Gastric Cancer Intestinal

  • Gastric Cancers

  • Gastric Carcinomas

  • Cancer, Gastric

  • Stomach Neoplasm

  • Malignant Neoplasm Of Body Of Stomach

  • Malignant Tumor Of Lesser Curve Of Stomach

  • Gastrocarcinoma Of Unspecified Site

  • Leather Bottle Stomach

  • Carcinoma Of Fundus Of Stomach

  • Cancer Of Fundus Of Stomach

  • Primary Malignant Neoplasm Of Body Of Stomach

  • Cancer Of Body Of Stomach

  • Primary Malignant Neoplasm Of Pyloric Antrum

  • Pyloric Antrum Cancer

  • Malignant Tumour Of Stomach
Hypertension, Essential

  • Essential Hypertension

  • Hypertension

  • High Blood Pressure

  • Hypertension, Essential, Susceptibility To

  • Hypertensive Disease

  • Primary Hypertension

  • EHT

  • Hypertension, Salt-Sensitive Essential, Susceptibility To

  • Hyperpiesia

  • Idiopathic Hypertension

  • Hypertensive Disorder

  • Hypertension, Essential, Susceptibility To, 3

  • Hypertension, Essential 3

  • Hypertension, Essential, Salt-Sensitive

  • Hypertension, Essential, Susceptibility To, 6

  • Hypertension, Essential 6

  • Hypertension, Salt-Sensitive Essential

  • Hypertension, Susceptibility To

  • Hypertension, Essential, Susceptibility To, 4

  • Hypertension, Essential 4

  • Hypertension, Essential, Susceptibility To, 2

  • Hypertension, Essential 2

  • Hypertension, Essential, Susceptibility To, 1

  • Hypertension, Essential 1

  • Hypertension, Essential, Susceptibility To, 5

  • Hypertension, Essential 5

  • Htn

  • Vascular Hypertensive Disorder

  • Systemic Primary Arterial Hypertension

  • Hbp - [High Blood Pressure]

  • Systemic Arterial Hypertensive Disorder

  • Elevated Blood Pressure

  • Arterial Hypertension Nos

  • Hypertension Nos

  • Benign Hypertension

  • Systemic Arterial Hypertension

  • Systemic Hypertension

  • Artery Htn

  • Benign Htn

  • Vascular Htn

  • Vascular Hypertension

  • Cholesterol Hypertension

  • Cholesterol Htn

  • Idiopathic Htn

  • Malignant Hypertension

  • Malignant Htn

  • Raised Blood Pressure

  • Cardiovascular Hypertension

  • Primary Htn - [Hypertension]

  • High Arterial Tension

  • High Blood Pressure Disorder

  • Ht - [Hypertension]

  • Htn - [Hypertension]

  • Hypertensive Vascular Disease

  • Hypertensive Vascular Degeneration
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04526 ESM1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18475 Esm1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24956 Esm1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris ESM1 VGNC VGNC:40474
Bos taurus ESM1 VGNC VGNC:28602
Mus musculus ESM1 MGD MGI:1918940
Macaca mulatta ESM1 VGNC VGNC:72431
Rattus norvegicus ESM1 RGD RGD:71013
Felis catus ESM1 VGNC VGNC:61962
Others ESM1 NCBI