Abca4 - ATP-binding cassette, sub-family A (ABC1), member 4 Gene

Also Known as RmP; Abcr; Abc10; D430003I15Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11304

Summary

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein was the first of the ABC transporters to be observed in photoreceptors and may play a role in the photoresponse. Mutations in the human gene are found in patients diagnosed with Stargardt disease and are associated with retinitis pigmentosa-19 and macular degeneration age-related 2. [provided by RefSeq, Jul 2008]

Abca4 Products (1)

mRNA Protein Name
NM_007378.1 NP_031404.1 retinal-specific phospholipid-transporting ATPase ABCA4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATPase-coupled intramembrane lipid transporter activity IMP
IMP: Inferred from mutant phenotype
10412977 MGI
enables N-retinylidene-phosphatidylethanolamine flippase activity IMP
IMP: Inferred from mutant phenotype
10412977 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within phospholipid transfer to membrane IMP
IMP: Inferred from mutant phenotype
10412977 MGI
acts upstream of or within photoreceptor cell maintenance IMP
IMP: Inferred from mutant phenotype
11431429 MGI
acts upstream of or within visual perception IMP
IMP: Inferred from mutant phenotype
10412977 MGI
Cellular Component GO Annotation Evidence References Source
located in photoreceptor outer segment IDA
IDA: Inferred from direct assay
9202155 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

retinal-specific phospholipid-transporting ATPase ABCA4

  • ATP-binding cassette 10

  • ATP-binding cassette sub-family A member 4

  • RIM ABC transporter

  • Rim protein

  • retinal-specific ATP-binding cassette transporter

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W004500 All-trans-retinal Inducer 99.56% Unkown
HY-183032 ABC transporter modulator-1 Activator 96.30% Unkown
HY-183033 ABC transporter modulator-2 Activator 96.89% Unkown
HY-183034 ABC transporter modulator-3 Activator 97.0% Unkown
HY-175664 EYE-003 Inhibitor / Unkown
HY-183035 ABC transporter modulator-4 Modulator / Unkown
HY-183036 ABC transporter modulator-5 Modulator / Unkown
HY-RS00042 ABCA4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Abca4 NCBI NCBI:24