HELQ - helicase, POLQ like Gene

Also Known as HEL308

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 113510

About HELQ

Cytogenetic location: 4q21.23 Genomic coordinates (GRCh38): 4:83,407,346-83,455,883 (from NCBI)

This gene has 6 transcripts (splice variants), 205 orthologues and 8 paralogues. Ubiquitous expression in adrenal (RPKM 4.5), ovary (RPKM 4.1) and 25 other tissues.

Summary

HEL308 is a single-stranded DNA-dependent ATPase and DNA helicase (Marini and Wood, 2002 [PubMed 11751861]).[supplied by OMIM, Mar 2008]

HELQ Products (6)

mRNA	Protein	Name
NM_001297755.2	NP_001284684.2	helicase POLQ-like isoform 2
NM_001297756.2	NP_001284685.1	helicase POLQ-like isoform 3
NM_001297757.2	NP_001284686.1	helicase POLQ-like isoform 4
NM_001297758.2	NP_001284687.2	helicase POLQ-like isoform 5
NM_001297759.2	NP_001284688.2	helicase POLQ-like isoform 6
NM_133636.5	NP_598375.3	helicase POLQ-like isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	24005329	GOA
enables single-stranded 3'-5' DNA helicase activity	IDA IDA: Inferred from direct assay	11751861	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA double-strand break processing involved in repair via single-strand annealing	IDA IDA: Inferred from direct assay	34937945	GOA
involved in double-strand break repair via alternative nonhomologous end joining	IDA IDA: Inferred from direct assay	34937945	GOA
involved in double-strand break repair via homologous recombination	IMP IMP: Inferred from mutant phenotype	19995904	GOA
involved in double-strand break repair via synthesis-dependent strand annealing	IDA IDA: Inferred from direct assay	34937945	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in nucleus	IDA IDA: Inferred from direct assay	34937945	GOA
is active in site of DNA damage	IDA IDA: Inferred from direct assay	34937945	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HELQ Protein Structure

DEAD

Helicase_C

0
200
400
600
800
1000
1101 a.a.

Protein Preferred Names	Protein Names
helicase POLQ-like	DNA helicase HEL308

HELQ Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	HELQ	Q8TDG4	RAD51C	Homo sapiens	O43502	Anti Bait CoIP	24005329
Intra	HELQ	Q8TDG4	RAD51C	Homo sapiens	O43502	Anti Tag CoIP	24005329

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Parkinsonism With Spasticity, X-Linked	X-Linked Parkinsonism-Spasticity Syndrome XPDS X-Linked Parkinsonism With Spasticity
Fanconi Anemia, Complementation Group C	Fanconi Anemia Complementation Group C FANCC Facc Fac Fa3 Fanconi Pancytopenia Type 3 Fanconi Pancytopenia, Type 3 Faces Syndrome Facial Features , Anorexia, Cachexia, Eye And Skin Anomalies Friedman-Goodman Syndrome Abnormality Of The Face
Premature Menopause	Primary Ovarian Insufficiency Premature Ovarian Failure Hypergonadotropic Hypogonadism Premature Ovarian Insufficiency Menopause - Premature Menopause Praecox Menopause Premature Menopause, Premature Female Hypergonadotropic Hypogonadism Hypergonadotrophic Ovarian Failure Primary Female Hypogonadism Pof - [Premature Ovarian Failure] Ovarian Failure Ovarian Secretion Suppression Ovary Hyposecretion Ovary Secretion Deficiency Premature Menopause Nos
Fanconi Anemia, Complementation Group A	Fanconi Anemia Fanconi Pancytopenia Fanconi Anemia Complementation Group A FANCA Fa Fanconi Panmyelopathy Fanconi'S Anemia Fanconi Anaemia Fanconi'S Anaemia Fanconi Hypoplastic Anemia Estren-Dameshek Variant Of Fanconi Anemia Estren-Dameshek Variant Of Fanconi Pancytopenia Fanconi Anemia Estren-Dameshek Variant Fanconis Anemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06116	HELQ Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	HELQ	VGNC	VGNC:62790
Bos taurus	HELQ	VGNC	VGNC:107247
Macaca mulatta	HELQ	VGNC	VGNC:73192
Canis familiaris	HELQ	VGNC	VGNC:41650
Mus musculus	HELQ	MGD	MGI:2176740
Rattus norvegicus	HELQ	RGD	RGD:1560216
Others	HELQ	NCBI