PIK3IP1 - phosphoinositide-3-kinase interacting protein 1 Gene

Also Known as HGFL; TrIP; hHGFL(S)

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 113791

About PIK3IP1

Cytogenetic location: 22q12.2 Genomic coordinates (GRCh38): 22:31,281,593-31,292,534 (from NCBI)

This gene has 6 transcripts (splice variants), 218 orthologues and 5 paralogues. Ubiquitous expression in lymph node (RPKM 60.4), appendix (RPKM 38.3) and 23 other tissues.

Summary

Enables phosphatidylinositol 3-kinase catalytic subunit binding activity. Involved in negative regulation of phosphatidylinositol 3-kinase activity and negative regulation of phosphatidylinositol 3-kinase signaling. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

PIK3IP1 Products (2)

mRNA Protein Name
NM_001135911.1 NP_001129383.1 phosphoinositide-3-kinase-interacting protein 1 isoform 2 precursor
NM_052880.5 NP_443112.2 phosphoinositide-3-kinase-interacting protein 1 isoform 1 precursor

PIK3IP1 Protein Structure

Kringle

Kringle: Kringle domain (25 - 87)

  • 0
  • 100
  • 200
  • 263 a.a.
Protein Preferred Names Protein Names

phosphoinositide-3-kinase-interacting protein 1

  • PI3K-interacting protein 1

PIK3IP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PIK3IP1 Q96FE7 UBQLN1 Homo sapiens Q9UMX0-2
Validated Y2H
25416956
Intra
PIK3IP1 Q96FE7 MAGEA11 Homo sapiens P43364
Y2H Prey Pooling
32296183
Intra
PIK3IP1 Q96FE7 MAGEA11 Homo sapiens P43364
Y2H Array
32296183
Intra
PIK3IP1 Q96FE7 UBQLN1 Homo sapiens Q9UMX0
Y2H Array
25416956
Intra
PIK3IP1 Q96FE7 UBQLN2 Homo sapiens Q9UHD9
Y2H Prey Pooling
32296183
Intra
PIK3IP1 Q96FE7 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32296183
Intra
PIK3IP1 Q96FE7 UBQLN2 Homo sapiens Q9UHD9
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PIK3IP1 Proteins

Cat. No. Product Name Accession Purity
HY-P71204 PIK3IP1 Protein, Human (HEK293, His) Q96FE7-1 (S22-T168) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Ovarian Clear Cell Carcinoma

  • Clear-Cell Ovarian Carcinoma
Endometrioid Ovary Carcinoma

  • Endometrioid Carcinoma Of Ovary

  • Endometrioid Carcinoma Ovary

  • Ovarian Endometrioid Carcinoma

  • Malignant Ovarian Endometrioid Tumor

  • Ovarian Endometrioid Tumor
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10535 PIK3IP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17178 Pik3ip1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23628 Pik3ip1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus PIK3IP1 VGNC VGNC:64177
Canis familiaris PIK3IP1 VGNC VGNC:44559
Bos taurus PIK3IP1 VGNC VGNC:32893
Rattus norvegicus PIK3IP1 RGD RGD:1311203
Mus musculus PIK3IP1 MGD MGI:1917016
Macaca mulatta PIK3IP1 VGNC VGNC:75859
Others PIK3IP1 NCBI