Cdc42bpb - CDC42 binding protein kinase beta Gene

Rattus norvegicus

Gene ID: 113960 | Gene type: protein coding

About Cdc42bpb

Summary

Enables protein serine/threonine kinase activity and small GTPase binding activity. Involved in actomyosin structure organization; cell migration; and protein phosphorylation. Located in actomyosin. Orthologous to human CDC42BPB (CDC42 binding protein kinase beta). [provided by Alliance of Genome Resources, Apr 2022]

Cdc42bpb Products(1)

mRNA	Protein	Name
NM_053620.3	NP_446072.2	serine/threonine-protein kinase MRCK beta

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18854160	RGD
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	9418861	RGD
enables small GTPase binding	IDA IDA: Inferred from direct assay	9418861	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	9418861	RGD
involved in actomyosin structure organization	IMP IMP: Inferred from mutant phenotype	18854160	RGD
involved in cell migration	IMP IMP: Inferred from mutant phenotype	18854160	RGD
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	9418861	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in actomyosin	IDA IDA: Inferred from direct assay	18854160	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

serine/threonine-protein kinase MRCK beta

CDC42 binding protein kinase beta (DMPK-like)	Cdc42-binding protein kinase beta
DMPK-like beta	MRCK beta
myotonic dystrophy kinase-related CDC42-binding kinase beta	myotonic dystrophy protein kinase-like beta

Cdc42bpb Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Cdc42bpb	Q7TT49	Lurap1	Rattus norvegicus	D4A8G3	Anti Bait CoIP	18854160

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02302	CDC42BPB Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cdc42bpb	NCBI	NCBI:9578

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