Plcz1 - phospholipase C, zeta 1 Gene

Also Known as PLCzeta; 1700041H07Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 114875

Summary

Enables phosphatidylinositol Phospholipase C activity. Involved in positive regulation of cytosolic calcium ion concentration involved in egg activation. Acts upstream of or within calcium ion transport and egg activation. Located in nucleolus; nucleoplasm; and pronucleus. Is expressed in several structures, including alimentary system; heart; integumental system; limb; and nervous system. Human ortholog(s) of this gene implicated in spermatogenic failure 17. Orthologous to human PLCZ1 (Phospholipase C zeta 1). [provided by Alliance of Genome Resources, Apr 2022]

Plcz1 Products (2)

mRNA Protein Name
NM_054066.4 NP_473407.2 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1
NM_054066.4 NP_473407.2 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables phosphatidylinositol phospholipase C activity IDA
IDA: Inferred from direct assay
14701816 MGI
enables phospholipase C activity IDA
IDA: Inferred from direct assay
12117804 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within calcium ion transport IDA
IDA: Inferred from direct assay
12117804 MGI
acts upstream of or within egg activation IDA
IDA: Inferred from direct assay
12117804 MGI
involved in positive regulation of cytosolic calcium ion concentration involved in egg activation IDA
IDA: Inferred from direct assay
18322275 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleolus IDA
IDA: Inferred from direct assay
18322275 MGI
located in nucleoplasm IDA
IDA: Inferred from direct assay
18322275 MGI
located in pronucleus IDA
IDA: Inferred from direct assay
18322275 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1

  • PLC-zeta-1

  • phosphoinositide phospholipase C-zeta-1

  • phospholipase C zeta

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10669 PLCZ1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Plcz1 NCBI NCBI:89869